Catalog No.
YHN58701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser201
Predicted molecular weight
25.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y5X0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Sorting nexin-10, SNX10
SNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway., PMID:40341994
SNX10 at the crossroad of endocytosis and piecemeal mitophagy., PMID:40327657
SNX10 deficiency impairs sensitivity to anti-HER2 antibody-drug conjugates via altering HER2 trafficking in HER2-positive breast cancer., PMID:40228127
Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2., PMID:40138451
SNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics., PMID:40052924
A comprehensive report of the clinical and mutational profiles of 30 Iranian malignant infantile osteopetrosis patients., PMID:39875016
FFA intervention on LO2 cells mediates SNX-10 synthesis and regulates MMP9 secretion in LX2 cells via TGF-β1., PMID:39662717
Gentisic acid prevents the development of atherosclerotic lesions by inhibiting SNX10-mediated stabilization of LRP6., PMID:39603572
Construction of a five-gene-based prognostic model for relapsed/refractory acute lymphoblastic leukemia., PMID:39453390
Differential analysis of sorting nexin 10 and sterol regulatory element-binding protein 2 expression in inflammatory bowel disease., PMID:39412576
Inhibiting SNX10 induces autophagy to suppress invasion and EMT and inhibits the PI3K/AKT pathway in cervical cancer., PMID:39367898
Integrative analysis of transcriptome-wide association study and mRNA expression profile identified risk genes for bipolar disorder., PMID:39151574
Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys., PMID:39147716
SNX10 regulates osteoclastogenic cell fusion and osteoclast size in mice., PMID:39095084
SNX10 promoted liver IR injury by facilitating macrophage M1 polarization via NLRP3 inflammasome activation., PMID:38271879
Ropivacaine inhibits the proliferation and metastasis of gastric cancer cells via the SNX10/SRC/STAT3 pathway., PMID:37989501
Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells., PMID:37647408
Genetics of sexually dimorphic adipose distribution in humans., PMID:36797366
Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting., PMID:36795488
α-hederin regulates glucose metabolism in intestinal epithelial cells by increasing SNX10 expression., PMID:36724620
Genome sequencing identifies a large non-coding region deletion of SNX10 causing autosomal recessive osteopetrosis., PMID:36526684
Long noncoding RNA H19 synergizes with STAT1 to regulate SNX10 in rheumatoid arthritis., PMID:36459790
CircRNA-Based Cervical Cancer Prognosis Model, Immunological Validation and Drug Prediction., PMID:36354693
Osteopetrosis associated with PLEKHM1 and SNX10 genes, both involved in osteoclast vesicular trafficking., PMID:35981699
Overexpression Pattern of miR-301b in Osteosarcoma and Its Relevance with Osteosarcoma Cellular Behaviors via Modulating SNX10., PMID:35732962
Evaluation of Host Protein Biomarkers by ELISA From Whole Lysed Peripheral Blood for Development of Diagnostic Tests for Active Tuberculosis., PMID:35720382
SNX10-mediated degradation of LAMP2A by NSAIDs inhibits chaperone-mediated autophagy and induces hepatic lipid accumulation., PMID:35265214
Identification of Key Amino Acid Residues Involved in the Localization of Sorting Nexin 10 and Induction of Vacuole Formation., PMID:34906048
SNX10 and caspase-5 sort out endosomal LPS for a gut-wrenching Slug-fest., PMID:34796973
SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade., PMID:34747049
Clinical presentation and analysis of genotype-phenotype correlations in patients with malignant infantile osteopetrosis., PMID:34624559
Differential gene expression analysis for osteosarcoma lung metastases., PMID:34511489
Single-cell immune checkpoint landscape of PBMCs stimulated with Candida albicans., PMID:34120578
SNX10 and PTGDS are associated with the progression and prognosis of cervical squamous cell carcinoma., PMID:34116656
Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation., PMID:34010669
An SNX10-dependent mechanism downregulates fusion between mature osteoclasts., PMID:33975343
SNX10 gene mutation in infantile malignant osteopetrosis: A case report and literature review., PMID:33678645
Long Non-Coding RNA Landscape in Prostate Cancer Molecular Subtypes: A Feature Selection Approach., PMID:33672425
Does Decreased SNX10 Serve as a Novel Risk Factor in Atrial Fibrillation of the Valvular Heart Disease? - A Case-Control Study., PMID:33594863
Oral Nanoparticles of SNX10-shRNA Plasmids Ameliorate Mouse Colitis., PMID:33488076
The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions., PMID:33241559
Combined Methylome and Transcriptome Analyses Reveals Potential Therapeutic Targets for EGFR Wild Type Lung Cancers with Low PD-L1 Expression., PMID:32899191
Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells., PMID:32398790
Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-Dependent TFEB Signaling Pathway., PMID:32316875
Massive osteopetrosis caused by non-functional osteoclasts in R51Q SNX10 mutant mice., PMID:32278070
Snx10 and PIKfyve are required for lysosome formation in osteoclasts., PMID:31692073
Osteopetrotic induced pluripotent stem cells derived from patients with different disease-associated mutations by non-integrating reprogramming methods., PMID:31315669
SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC., PMID:31208298
Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits., PMID:31186305
Intermediate autosomal recessive osteopetrosis with a large noncoding deletion in SNX10: A case report., PMID:30977576
For research use only. Not for human or drug use.
