Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Recombinant Protein / Other Proteins

Recombinant Mouse GCH1 Protein, N-His

Catalog #:   YMD91101 Specific References (50) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: Q05915
Protein length: Val57-Ser241
Overview

Catalog No.

YMD91101

Expression system

E. coli

Species

Mus musculus (Mouse)

Protein length

Val57-Ser241

Predicted molecular weight

22.85 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q05915

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

GCH1, GTP cyclohydrolase I, DYT5, GTP cyclohydrolase 1, GTP-CH-I, GCH

Data Image
References

Screening for biomarkers of bronchopulmonary dysplasia: a bioinformatics analysis., PMID:40386354

Ferroptosis and renal fibrosis: mechanistic insights and emerging therapeutic targets., PMID:40329437

Association of GCH1 polymorphism with Parkinson disease susceptibility: A meta-analysis., PMID:40258736

Clinical and Basic Research on Dopa-Responsive Dystonia: Neuropathological and Neurochemical Findings., PMID:40109402

Cancer-associated fibroblasts promote doxorubicin resistance in triple-negative breast cancer through enhancing ZFP64 histone lactylation to regulate ferroptosis., PMID:40022222

Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc-/GPX4 pathway., PMID:39944356

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling., PMID:39941119

Functional movement disorders in dopa-responsive dystonia., PMID:39848138

Pathogenic Variant in the 5'-Untranslated Region of GCH1 and Clinical Heterogeneity in a Chinese Family with Dopa-Responsive Dystonia., PMID:39801809

Prognostic significance and therapeutic potential of guanosine triphosphate cyclohydrolase 1 in esophageal squamous cell carcinoma: clinical implications of ferroptosis and lipid peroxidation regulation., PMID:39723384

CTRP13 attenuates atherosclerosis by inhibiting endothelial cell ferroptosis via activating GCH1., PMID:39541845

Association of Amyotrophic Lateral Sclerosis and Dopa-responsive dystonia in a Tunisian patient., PMID:39531950

Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain., PMID:39178277

Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration., PMID:39153477

Enhancement of Haloperidol-Induced Catalepsy by GPR143, an l-DOPA Receptor, in Striatal Cholinergic Interneurons., PMID:39142836

Comparative Transcriptome Analysis Reveals Differential Cutaneous Gene Expression in the Color Variation of Two Ornamental Discus, Red Melon and Red Cover., PMID:39140294

Characterization of Dnajc12 knockout mice, a model of hypodopaminergia., PMID:39026821

Autosomal Recessive Guanosine Triphosphate Cyclohydrolase I Deficiency: Redefining the Phenotypic Spectrum and Outcomes., PMID:39001623

Citronellal improves endothelial dysfunction by affecting the stability of the GCH1 protein., PMID:38993132

De novo p.Glu61Ter mutation in GCH1 in a Moroccan patient with dopa-responsive dystonia: a case report., PMID:38974698

Inhibition of Ferroptosis by Mesenchymal Stem Cell-Derived Exosomes in Acute Spinal Cord Injury: Role of Nrf2/GCH1/BH4 Axis., PMID:38955534

Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST mediated ferroptosis suppression., PMID:38906233

Identification of an inflammatory response-related gene prognostic signature and immune microenvironment for cervical cancer., PMID:38903179

Genetic Influence on Capsaicin Tolerance: Precision Nutrition Implications for Obesity Handling., PMID:38810602

Sex Differences in Dystonia., PMID:38778444

Long non‑coding RNA lung cancer‑associated transcript 1 regulates ferroptosis via microRNA‑34a‑5p‑mediated GTP cyclohydrolase 1 downregulation in lung cancer cells., PMID:38757341

Tetrahydrobiopterin metabolism attenuates ROS generation and radiosensitivity through LDHA S-nitrosylation: novel insight into radiogenic lung injury., PMID:38689083

FSP1-mediated ferroptosis in cancer: from mechanisms to therapeutic applications., PMID:38615304

An Inversion Affecting the GCH1 Gene as a Novel Finding in Dopa-Responsive Dystonia., PMID:38497520

Triphenyltin induced darker body coloration by disrupting melanocortin system and pteridine metabolic pathway in a reef fish, Amphiprion ocellaris., PMID:38461573

Dissecting genetic architecture of rare dystonia: genetic, molecular and clinical insights., PMID:38458754

Host transcriptomics and machine learning for secondary bacterial infections in patients with COVID-19: a prospective, observational cohort study., PMID:38310908

Nur77 mitigates endothelial dysfunction through activation of both nitric oxide production and anti-oxidant pathways., PMID:38290383

Large-Scale Screening: Phenotypic and Mutational Spectrum in Isolated and Combined Dystonia Genes., PMID:38214203

Tyrosine hydroxylase variants influence protein expression, cellular localization, stability, enzymatic activity and the physical interaction between tyrosine hydroxylase and GTP cyclohydrolase 1., PMID:38084654

Endogenous chemicals guard health through inhibiting ferroptotic cell death., PMID:38059412

SRSF1 inhibits ferroptosis and reduces cisplatin chemosensitivity of triple-negative breast cancer cells through the circSEPT9/GCH1 axis., PMID:38040194

A review on the research progress of traditional Chinese medicine with anti-cancer effect targeting ferroptosis., PMID:37833746

Importance of targeted next-generation sequencing in pediatric patients with developmental epileptic encephalopathy., PMID:37820178

GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis., PMID:37735250

Catecholamines and Parkinson's disease: tyrosine hydroxylase (TH) over tetrahydrobiopterin (BH4) and GTP cyclohydrolase I (GCH1) to cytokines, neuromelanin, and gene therapy: a historical overview., PMID:37638996

Whole exome sequencing and clinical investigation of young onset dystonia: What can we learn?, PMID:37607452

Effects of DNA, RNA, and Protein Methylation on the Regulation of Ferroptosis., PMID:37497000

GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner., PMID:37463466

Implementation of a Drug Screening Platform to TargetGch1 Expression in Injured Mouse Dorsal Root Ganglion Neurons., PMID:37188109

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury., PMID:37184360

17β-Estradiol Suppresses Gastric Inflammatory and Apoptotic Stress Responses and Restores nNOS-Mediated Gastric Emptying in Streptozotocin (STZ)-Induced Diabetic Female Mice., PMID:36979006

Ninety-six-hour starved peripheral blood mononuclear cell supernatant inhibited LA7 breast cancer stem cells induced tumor via reduction in angiogenesis and alternations in Gch1 and Spr expressions., PMID:36908807

Genetic screening of Filipinos suspected with familial Parkinson's disease: A pilot study., PMID:36774704

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury., PMID:36735402

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Recombinant Mouse GCH1 Protein, N-His [YMD91101]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only