Catalog No.
AHJ80901
Biological activity
Measured by its ability to cleave a fluorogenic peptide substrate Mca-PLAQAV-Dpa-RSSSR-NH2. The specific activity is >150 pmol/min/μg, as measured under the described condition.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala39-Ser531 (Arg125Pro，Ala182Thr)
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ULZ9
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Membrane-type matrix metalloproteinase 4, MT-MMP 4, MT4-MMP, Matrix metalloproteinase-17, MMP-17, Membrane-type-4 matrix metalloproteinase, MMP17, MTMMP4, MT4MMP
Immunotyping of thyroid cancer for clinical outcomes and implications., PMID:40418400
The Effect of Curcumin on the Activity of MMP-17 and MMP-24 in Hepatocytes of Mice Exposed to Thioacetamide., PMID:40330566
Structure of the ATP-driven methyl-coenzyme M reductase activation complex., PMID:40240609
Plasma concentration of MMP-17 is elevated in boys with cryptorchidism and correlates with HSP-70., PMID:39747260
Combinatorial metabolomic and transcriptomic analysis of muscle growth in hybrid striped bass (female white bass Morone chrysops x male striped bass M. saxatilis)., PMID:38858615
Single-Cell Transcriptome Reveals Potential Mechanisms for Coronary Artery Lesions in Kawasaki Disease., PMID:38357816
Elevated Plasma Levels of MT4-MMP and MT6-MMP; A New Observation in Patients with Thyroid Nodules., PMID:38310435
Doxycycline hydrochloride inhibits the progress of malignant rhabdoid tumor of kidney by targeting MMP17 and MMP1 through PI3K-Akt signaling pathway., PMID:38158115
Mmp17-deficient mice exhibit heightened goblet cell effector expression in the colon and increased resistance to chronic Trichuris muris infection., PMID:37869014
The Influence of Race/Ethnicity on the Transcriptomic Landscape of Uterine Fibroids., PMID:37686244
MMP11 and MMP17 are potential biomarkers for uterine corpus endometrial carcinoma prognosis., PMID:37523078
Prognostic risk factors of serous ovarian carcinoma based on mesenchymal stem cell phenotype and guidance for therapeutic efficacy., PMID:37434173
An artificial intelligence prediction model based on extracellular matrix proteins for the prognostic prediction and immunotherapeutic evaluation of ovarian serous adenocarcinoma., PMID:37388244
Molecular Mechanisms Driven by MT4-MMP in Cancer Progression., PMID:37373092
Expression and clinical significance of TYRP1, ABCB5, and MMP17 in sinonasal mucosal melanoma., PMID:36373310
Matrix metalloproteinase gene mutations and bioinformatics of telocytes in hepatocellular carcinoma., PMID:36273423
Increased expression of MMP17 predicts poor clinical outcomes in epithelial ovarian cancer patients., PMID:36042626
Weighted Gene Co-expression Network Analysis Identifies Specific Modules and Hub Genes Related to Subacute Ruminal Acidosis., PMID:35754546
RNA-Seq analysis reveals sex-dependent transcriptomic profiles of human subacromial bursa stratified by tear etiology., PMID:35266580
Genome-Wide Association Study of the Relationship Between Matrix Metalloproteinases and Intracranial Aneurysms., PMID:35196751
Soluble CD40 receptor is a biomarker of the burden of carotid artery atherosclerosis in subjects at high cardiovascular risk., PMID:35078015
Landscape Analysis of Matrix Metalloproteinases Unveils Key Prognostic Markers for Patients With Breast Cancer., PMID:35069702
Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer., PMID:34804973
Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage., PMID:34795242
Comparative transcriptomic analysis reveals the gonadal development-related gene response to environmental temperature in Mauremys mutica., PMID:34689019
MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma., PMID:34587931
A novel circular RNA, hsa_circ_0030998 suppresses lung cancer tumorigenesis and Taxol resistance by sponging miR-558., PMID:33190405
MMPphg from the thermophilic Meiothermus bacteriophage MMP17 as a potential antimicrobial agent against both Gram-negative and Gram-positive bacteria., PMID:32843096
Identification of potential proteases for abdominal aortic aneurysm by weighted gene coexpression network analysis., PMID:32783773
MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells., PMID:31813546
MT4-MMP: The GPI-Anchored Membrane-Type Matrix Metalloprotease with Multiple Functions in Diseases., PMID:30654475
Expression of MT4-MMP, EGFR, and RB in Triple-Negative Breast Cancer Strongly Sensitizes Tumors to Erlotinib and Palbociclib Combination Therapy., PMID:30504427
miRNA‑27a regulates arthritis via PPARγ in vivo and in vitro., PMID:29393373
Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy., PMID:29039471
Developmental expression of membrane type 4-matrix metalloproteinase (Mt4-mmp/Mmp17) in the mouse embryo., PMID:28926609
Expression and Characterization of Membrane-Type 4 Matrix Metalloproteinase (MT4-MMP) and its Different Forms in Melanoma., PMID:28531887
MT4-MMP and EGFR expression levels are key biomarkers for breast cancer patient response to chemotherapy and erlotinib., PMID:28196064
Identifying key stage-specific genes and transcription factors for gastric cancer based on RNA-sequencing data., PMID:28121923
Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells., PMID:26663028
Serum metalloproteinases 1 and 7 in the diagnosis of idiopathic pulmonary fibrosis and other interstitial pneumonias., PMID:26174192
MMP17/MT4-MMP and thoracic aortic aneurysms: OPNing new potential for effective treatment., PMID:26139854
Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice., PMID:25963716
Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer., PMID:25373480
EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP., PMID:25320013
Curcumin inhibits the invasion of thyroid cancer cells via down-regulation of PI3K/Akt signaling pathway., PMID:24910117
Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer., PMID:24807047
Effects of thymoquinone on STZ-induced diabetic nephropathy: an immunohistochemical study., PMID:24134725
Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression., PMID:23850346
Expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma., PMID:23318052
MT-MMPs in pre-eclamptic placenta: relationship to soluble endoglin production., PMID:23261267
For research use only. Not for human or drug use.
