Catalog No.
AHJ66301
Biological activity
Measured by its ability to bind recombinant human IL-17E in a functional ELISA.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg18-Gly289
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NRM6
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-17B receptor, CRL4, IL17RB, Cytokine receptor-like 4, IL-17RB, IL17BR, IL-17 receptor B, Interleukin-17B receptor, EVI27, Interleukin-17 receptor B, IL17Rh1, IL-17Rh1, IL-17 receptor homolog 1
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis., PMID:40434419
Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer., PMID:40316856
Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB., PMID:40199322
Clinical efficacy and chemoresistance analysis of precision neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a prospective, single-arm pilot study., PMID:40146255
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation., PMID:40074948
Differential roles of IL-17B and IL-17RB in colorectal cancer: Correlation with immune infiltration and prognosis., PMID:40020328
Identification of the key role of IL-17RB in the treatment of osteoarthritis with Shaoyao Gancao decoction: Verification based on RNA-seq and bioinformatics analysis., PMID:39964979
Innovative cyclic peptide disrupts IL-17RB-MLK4 interaction for targeted pancreatic cancer therapy., PMID:39913969
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase., PMID:39879985
IL-25 Enhances B Cell Responses in Type 2 Inflammation Through IL-17RB Receptor., PMID:39829150
Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial., PMID:39717777
Mutational Landscape of Bone Marrow CD19 and CD138 Cells in Waldenström Macroglobulinemia (WM) and IgM Monoclonal Gammopathy of Undetermined Significance (IgM MGUS)., PMID:39711167
ERBB2/HOXB13 co-amplification with interstitial loss of BRCA1 defines a unique subset of breast cancers., PMID:39695741
STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment., PMID:39547223
Expression of Epithelial Alarmin Receptor on Innate Lymphoid Cells Type 2 in Eosinophilic Chronic Obstructive Pulmonary Disease., PMID:39452061
SEMA7A-mediated juxtacrine stimulation of IGFBP-3 upregulates IL-17RB at pancreatic cancer invasive front., PMID:39448803
TCF-1 and TOX regulate the memory formation of intestinal group 2 innate lymphoid cells in asthma., PMID:39245681
CRL4-DCAF1 Ubiquitin Ligase Dependent Functions of HIV Viral Protein R and Viral Protein X., PMID:39205287
Breast Cancer Index in Premenopausal Women With Early-Stage Hormone Receptor-Positive Breast Cancer., PMID:39145953
Cullin-RING Ligase 4 in Cancer: Structure, Functions, and Mechanisms., PMID:39117093
IL-17B alleviates the pathogenesis of systemic lupus erythematosus by inhibiting FASN-mediated differentiation of B cells., PMID:39115936
The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics., PMID:39075067
Targeting Ikaros and Aiolos: reviewing novel protein degraders for the treatment of multiple myeloma, with a focus on iberdomide and mezigdomide., PMID:39054911
Endometrial senescence is mediated by interleukin 17 receptor B signaling., PMID:39010112
Stage-specific GATA3 induction promotes ILC2 development after lineage commitment., PMID:38969652
IL17RB genetic variants are associated with acamprosate treatment response in patients with alcohol use disorder: A proteomics-informed genomics study., PMID:38852760
Identification and functional characterization of fish IL-17 receptors suggest important roles in the response to nodavirus infection., PMID:38827125
A chemical probe to modulate human GID4 Pro/N-degron interactions., PMID:38773330
Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation., PMID:38768083
A conserved N-terminal motif of CUL3 contributes to assembly and E3 ligase activity of CRL3KLHL22., PMID:38710693
Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase., PMID:38670995
Transcription-coupled DNA-protein crosslink repair by CSB and CRL4CSA-mediated degradation., PMID:38600236
Transcription-coupled repair of DNA-protein cross-links depends on CSA and CSB., PMID:38600235
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation., PMID:38496438
Interleukin-17 and inflammatory bowel disease: a 2-sample Mendelian randomization study., PMID:38045694
IL-25 induces airway remodeling in asthma by orchestrating the phenotypic changes of epithelial cell and fibrocyte., PMID:37635231
IL-25 Impact on Malignant B Cells Survival and T Cells Activation in Chronic Lymphocytic Leukemia., PMID:37524666
IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer., PMID:37448179
CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration., PMID:37194082
Diet-mediated constitutive induction of novel IL-4+ ILC2 cells maintains intestinal homeostasis in mice., PMID:37163450
IL17RB and IL17REL Expression Are Associated with Improved Prognosis in HPV-Infected Head and Neck Squamous Cell Carcinomas., PMID:37111458
FAIM2 is correlated with metastasis of medulloblastoma through bioinformatics analysis., PMID:37083768
Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood., PMID:36685501
IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury., PMID:36543124
Uncovering the degrader of D-type cyclins., PMID:36423267
Structural basis of interleukin-17B receptor in complex with a neutralizing antibody for guiding humanization and affinity maturation., PMID:36288706
Construction of a Colorectal Cancer Prognostic Risk Model and Screening of Prognostic Risk Genes Using Machine-Learning Algorithms., PMID:36267311
Chronic allergic asthma alters m6A epitranscriptomic tagging of mRNAs and lncRNAs in the lung., PMID:36250525
IL-25 ameliorates acute cholestatic liver injury via promoting hepatic bile acid secretion., PMID:35914403
Gene Expression Profile of Stromal Factors in Cancer-Associated Fibroblasts from Prostate Cancer., PMID:35885510
For research use only. Not for human or drug use.
