Catalog No.
AMJ75601
Biological activity
Measured by its ability to induce IL-6 secretion by mouse embryonic fibroblast cells (NIH‑3T3). The ED50 for this effect is typically 3-18 ng/mL.
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Arg8-His160
Nature
Recombinant
Endotoxin level
<1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9JLA2
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-36 alpha, Il1h1, Il36a, Il1e, Interleukin-1 family member 6, Il1f6, IL-1 epsilon, IL-1H1, Fil1e, IL-1F6, Interleukin-1 homolog 1, Interleukin-1 epsilon, FIL1 epsilon
Identification of Interleukin-Related Genes Signature for Prognosis Prediction in Head and Neck Squamous Cell Carcinoma Patients., PMID:39917898
Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030
Expanding Role of Interleukin-1 Family Cytokines in Acute Ischemic Stroke., PMID:39408843
Identifying novel proteins underlying bipolar disorder via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data., PMID:39191728
Uncovering novel drug targets for bipolar disorder: a Mendelian randomization analysis of brain, cerebrospinal fluid, and plasma proteomes., PMID:38720515
The Clinical Significance of Serum Interleukin-36α Levels in Patients with Gout., PMID:38638029
Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis., PMID:38203575
Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases., PMID:38189700
Psoriasis and Leprosy: An Arcane Relationship., PMID:37337513
Age of onset defines two distinct profiles of atopic dermatitis in adults., PMID:37032461
Plasma IL-36α and IL-36γ as Potential Biomarkers in Interstitial Lung Disease Associated with Rheumatoid Arthritis: a Pilot Study in the Chinese Population., PMID:36044099
IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic., PMID:35903102
IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease., PMID:35698471
Interleukin-36α is elevated in diffuse systemic sclerosis and may potentiate fibrosis., PMID:35667282
The Emerging Roles of IL-36, IL-37, and IL-38 in Diabetes Mellitus and its Complications., PMID:35049442
Decreased serum profile of the interleukin-36α in polycystic ovary syndrome., PMID:34794731
Analysis of Il36a induction by C/EBPβ via a half-CRE•C/EBP element in murine macrophages in dependence of its CpG methylation level., PMID:34697411
Interleukin-36α inhibits colorectal cancer metastasis by enhancing the infiltration and activity of CD8+ T lymphocytes., PMID:34555640
IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore., PMID:34365521
Mast Cell Cytokines IL-1, IL-33, and IL-36 Mediate Skin Inflammation in Psoriasis: A Novel Therapeutic Approach with the Anti-Inflammatory Cytokines IL-37, IL-38, and IL-1Ra., PMID:34360845
IL-36α and IL-36γ expressions in the differential diagnosis of palmoplantar psoriasis and palmoplantar eczema: A retrospective histopathologic and immunohistochemical study., PMID:34289144
Association of interleukin-36α gene expression in Egyptian patients with systemic lupus erythematosus with organ involvement and disease activity., PMID:34185456
Interleukin-36α suppresses growth of non-small cell lung cancer in vitro by reducing angiogenesis., PMID:33713575
Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease., PMID:33645549
IL-36 in chronic inflammation and fibrosis - bridging the gap?, PMID:33463541
Altered serum levels of IL-36 cytokines (IL-36α, IL-36β, IL-36γ, and IL-36Ra) and their potential roles in Guillain-Barré syndrome., PMID:33350771
Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation., PMID:33034926
Atopic dermatitis displays stable and dynamic skin transcriptome signatures., PMID:32615169
3D model of harlequin ichthyosis reveals inflammatory therapeutic targets., PMID:32544098
Saliva proteomics from children with caries at different severity stages., PMID:32285988
Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia., PMID:32159969
IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer?, PMID:32013927
Keratin 5-Cre-driven deletion of Ncstn in an acne inversa-like mouse model leads to a markedly increased IL-36a and Sprr2 expression., PMID:31884525
Reduced stratum corneum acylceramides in autosomal recessive congenital ichthyosis with a NIPAL4 mutation., PMID:31836270
Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases., PMID:31736959
Structural insights into heme binding to IL-36α proinflammatory cytokine., PMID:31729440
Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes., PMID:31682009
IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners., PMID:31619669
Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis., PMID:31504934
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease., PMID:31427775
Upregulation of IL-36 cytokines in folliculitis and eosinophilic pustular folliculitis., PMID:31424098
Fatigue in Sjögren's Syndrome: A Search for Biomarkers and Treatment Targets., PMID:30863411
Interleukin-36 alpha levels are elevated in the serum and cerebrospinal fluid of patients with neuromyelitis optica spectrum disorder and correlate with disease activity., PMID:30852049
Interleukin-1 family cytokines and mast cells: activation and inhibition., PMID:30656901
Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation., PMID:30452921
IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis., PMID:30417427
Sublytic C5b-9 Induces IL-23 and IL-36a Production by Glomerular Mesangial Cells via PCAF-Mediated KLF4 Acetylation in Rat Thy-1 Nephritis., PMID:30404815
Meta-analysis of RNA sequencing datasets reveals an association between TRAJ23, psoriasis, and IL-17A., PMID:29997305
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature., PMID:29803800
Overexpression of interleukin-35 in intrahepatic cholangiocarcinoma is a prognostic indicator after curative resection., PMID:29446854
For research use only. Not for human or drug use.
