Catalog No.
AHJ48201
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of mouse vascular endothelial cells (SVEC4‑10) to Fibronectin. Recombinant human SEMA3C (Cat #: AHJ48201) immobilized at 10 μg/mL, with 2 ng/mL rhFN-1, 100 μL/well, will induce approximately 50-75% adhesion.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly21-Ser738 (Arg551Ala, Arg552Ala, Arg611Ala, Arg612Ala)
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99985
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SEMA3C, Semaphorin-E, Semaphorin-3C, SEMAE, Sema E
Cumulative Effects of Genetic Variants Detected in a Child with Early-Onset Non-Syndromic Obesity Due to SIM-1 Gene Mutation., PMID:40428410
Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation., PMID:40402249
Thymoquinone enhances efficacy of cervical Cancer therapeutic vaccines via modulating CD8+ T cells., PMID:40316484
KLF6-mediated recruitment of the p300 complex enhances H3K23su and cooperatively upregulates SEMA3C with FOSL2 to drive 5-FU resistance in colon cancer cells., PMID:40082673
Identifying semaphorin 3C as a biomarker for sarcopenia and coronary artery disease via bioinformatics and machine learning., PMID:39827515
SEMA3C promotes thyroid cancer via the Wnt/β-catenin pathway., PMID:39667698
Construction and validation of a prognostic signature based on microvascular invasion and immune-related genes in hepatocellular carcinoma., PMID:39506070
High Polygenic Risk Scores Positively Associated with Gastric Cancer Risk Interact with Coffee and Polyphenol Intake and Smoking Status in Korean Adults., PMID:39408230
Macrophages play a crucial role in vascular smooth muscle cell coverage., PMID:39166965
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression., PMID:38956074
Human Genetics of Truncus Arteriosus., PMID:38884753
Lhx2 promotes axon regeneration of adult retinal ganglion cells and rescues neurodegeneration in mouse models of glaucoma., PMID:38729157
Clinically-observed FOXA1 mutations upregulate SEMA3C through transcriptional derepression in prostate cancer., PMID:38528115
Fibroblasts facilitate lymphatic vessel formation in transplanted heart., PMID:38505621
Paired-Related Homeobox 1-Positive Cells Are Needed for Osseointegration., PMID:38498783
Unique tRNA Fragment Upregulation with SARS-CoV-2 but Not with SARS-CoV Infection., PMID:38203569
Spirulina Supplementation with High-Intensity Interval Training Decreases Adipokines Levels and Cardiovascular Risk Factors in Men with Obesity., PMID:38068748
Potential drug targets for myocardial infarction identified through Mendelian randomization analysis and Genetic colocalization., PMID:38065874
Modulation of semaphorin 3C & 4D expression in cancerous tissues from individuals with laryngeal squamous cell carcinoma., PMID:38006346
Astaxanthin Supplementation Augments the Benefits of CrossFit Workouts on Semaphorin 3C and Other Adipokines in Males with Obesity., PMID:38004197
Semaphorin 3C promotes de novo steroidogenesis in prostate cancer cells., PMID:37800655
An Anterior Second Heart Field Enhancer Regulates the Gene Regulatory Network of the Cardiac Outflow Tract., PMID:37772400
Whole-Genome Resequencing Reveals Selection Signal Related to Sheep Wool Fineness., PMID:37760343
Primary ductal adenocarcinoma of the lacrimal gland with sarcomatoid differentiation: case report and genomic analysis., PMID:37611021
B-type Plexins promote the GTPase activity of Ran to affect androgen receptor nuclear translocation in prostate cancer., PMID:37563360
Semaphorin 3 C enhances putative cancer stemness and accelerates peritoneal dissemination in pancreatic cancer., PMID:37537633
Dependency of Tamoxifen Sensitive and Resistant ER+ Breast Cancer Cells on Semaphorin 3C (SEMA3C) for Growth., PMID:37443749
FOXM1: Functional Roles of FOXM1 in Non-Malignant Diseases., PMID:37238726
Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma., PMID:37080989
Semaphorin 3C exacerbates liver fibrosis., PMID:37055018
Emerging roles and mechanisms of semaphorins activity in cancer., PMID:36775114
A Novel Role of Semaphorin 3C in Modulating Systemic and Renal Hemodynamics., PMID:36580904
CCN4/WISP1 Promotes Migration of Human Primary Osteoarthritic Chondrocytes., PMID:36546648
Five immune-related genes as diagnostic markers for endometriosis and their correlation with immune infiltration., PMID:36277723
Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney., PMID:36266461
Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity., PMID:36240771
Whole-genome sequencing reveals de-novo mutations associated with nonsyndromic cleft lip/palate., PMID:35817949
Identity of MMP1 and its effects on tumor progression in head and neck squamous cell carcinoma., PMID:35426219
[The expression of semaphorins in synovial tissue of knee joint in patients with rheumatoid arthritis is increased and positively correlated with clinical inflammatory markers]., PMID:35356884
Semaphorin class 3C, vascular permeability, and the swollen injured kidney., PMID:35314049
Investigation of an FGFR-Signaling-Related Prognostic Model and Immune Landscape in Head and Neck Squamous Cell Carcinoma., PMID:35237609
Genetic inactivation of Semaphorin 3C protects mice from acute kidney injury., PMID:35090878
FOXM1 accelerates wound healing in diabetic foot ulcer by inducing M2 macrophage polarization through a mechanism involving SEMA3C/NRP2/Hedgehog signaling., PMID:34742786
Whole-genome sequencing identifies functional noncoding variation in SEMA3C that cosegregates with dyslexia in a multigenerational family., PMID:34076780
Binge-Like Ethanol Drinking Increases Otx2, Wnt1, and Mdk Gene Expression in the Ventral Tegmental Area of Adult Mice., PMID:33954290
Ferulic Acid Stimulates Adipocyte-Specific Secretory Proteins to Regulate Adipose Homeostasis in 3T3-L1 Adipocytes., PMID:33915783
Sema3C promotes hepatic metastasis and predicts poor prognosis in gastric adenocarcinoma., PMID:33909533
HAND transcription factors cooperatively specify the aorta and pulmonary trunk., PMID:33757801
LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C., PMID:33568674
Effect of semaphorin 3C gene variants in multifactorial Hirschsprung disease., PMID:33557656
For research use only. Not for human or drug use.
