Catalog No.
AHJ30701
Biological activity
Measured by its binding ability in a functional ELISA, immobilized IL38/IL1F10 (Cat #: AHJ30701) at 1 µg/ml (100 µl/well) can bind rhIL1R-rp2 with a linear range of 0.15-5 µg/ml.
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Trp152
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WWZ1
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-1 theta, IL-38, IL1HY2, Interleukin-1 HY2, IL38, Family of interleukin 1-theta, FIL1 theta, IL-1 theta, Interleukin-1 family member 10, IL-1HY2, Interleukin-38, IL1F10, IL-1F10, FIL1T
Modulation of interleukins 38 and 1 Beta gene expression by N-(4-benzoylphenyl)-5-nitrofuran-2-carboxamide in Triton WR-1339 induced hyperlipidemic rats., PMID:40514672
The distinct roles of IL-37 and IL-38 in non-small cell lung carcinoma and their clinical implications., PMID:40191189
The complex roles of IL-36 and IL-38 in cancer: friends or foes?, PMID:40057603
The protective role of muscone in the development of COPD., PMID:40034710
Interleukin-38 as a potential diagnostic biomarker for heart failure., PMID:39949181
IL-38 attenuates renal ischemia/reperfusion injury through suppressing inflammation in mice., PMID:39910943
Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors., PMID:39833821
Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease., PMID:39800261
Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3+ regulatory T cells., PMID:39667222
Prevalence and Risk Factors of Pulmonary Embolism in COPD Patients Complicated with Secondary Polycythemia., PMID:39512997
Increased circulating levels of novel anti-inflammatory cytokines IL-27 and IL-38 are associated with immunoendrocrine dysregulation and altered redox stress in polycystic ovarian syndrome., PMID:39509823
The decreased serum levels of interleukin-38 in patients with gout and its clinical significance., PMID:39483458
Oxidation-sensitive cysteines drive IL-38 amyloid formation., PMID:39488827
Interleukin-38 ameliorates myocardial Ischemia-Reperfusion injury via inhibition of NLRP3 inflammasome activation in fibroblasts through the IL-1R8/SYK axis., PMID:39447412
The role of selected cytokines from the interleukin-1 family in the peritoneal fluid of women with endometriosis., PMID:39411821
Expanding Role of Interleukin-1 Family Cytokines in Acute Ischemic Stroke., PMID:39408843
Interleukin 38 reduces antigen-presentation capacity and antibody production after vaccination., PMID:39353267
The role of Interleukin-38 in modulating T cells in chronic Colitis: A mouse model study., PMID:39342821
IL-17 and IL-38 gene polymorphisms in thyroid-associated ophthalmopathy., PMID:39292290
Autoantibody mediated deficiency of IL-36-receptor antagonist in a subset of patients with psoriasis and psoriatic arthritis., PMID:39265919
Investigation of pre and postoperative Th1/Th2 cytokine balance and novel cytokines in colorectal cancer patients., PMID:39230623
Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapy., PMID:39209451
Potential roles of IL-38, among other inflammation-related biomarkers, in predicting post-percutaneous coronary intervention cardiovascular events., PMID:39156131
Interleukin-38 overexpression in keratinocytes limits desquamation but does not affect the global severity of imiquimod-induced skin inflammation in mice., PMID:39119344
Decreased serum IL-38 levels in pemphigus vulgaris., PMID:38963087
IL-38 Aggravates Atopic Dermatitis via Facilitating Migration of Langerhans cells., PMID:38904012
Interleukin 38 improves insulin resistance in hyperlipidemic skeletal muscle cells via PPARδ/SIRT1-mediated suppression of STAT3 signaling and oxidative stress., PMID:38795455
IL-38 promotes the development of prostate cancer., PMID:38779687
The 5' untranslated region variant rs3811050 C/T of the interleukin-38 encoding gene is associated with susceptibility to rheumatoid arthritis in Iraqi women., PMID:38683405
AMPK/autophagy-mediated alleviation of tendinopathy by IL-38: A novel strategy for the treatment of obesity-related tendinopathy., PMID:38643674
Serum PYCARD may become a new diagnostic marker for rheumatoid arthritis patients., PMID:38576041
Age-Related Effects on MSC Immunomodulation, Macrophage Polarization, Apoptosis, and Bone Regeneration Correlate with IL-38 Expression., PMID:38542230
Exploring the clinical significance of IL-38 correlation with PD-1, CTLA-4, and FOXP3 in colorectal cancer draining lymph nodes., PMID:38533512
Evaluation of Salivary Il-38 Levels in Periodontitis: A Cross-Sectional Study., PMID:38497769
Serum Interleukin-38 and Tumor-Infiltrating Lymphocytes in Primary Brain Tumors., PMID:38372219
Emerging functions and therapeutic targets of IL-38 in central nervous system diseases., PMID:38334236
Emerging Role of Interleukin-38 (IL-38) in the Development of Rheumatoid Arthritis., PMID:38315401
IL-38 in Behçet's disease: Gene expression in bronchoalveolar lavage from patients having pulmonary involvement., PMID:38307260
Whether full-length IL-38 acts as a promoter or inhibitor in activating rheumatoid arthritis fibroblast-like synoviocytes depends on IL-1β., PMID:38287552
Interleukin-38 alleviates hepatic steatosis through AMPK/autophagy-mediated suppression of endoplasmic reticulum stress in obesity models., PMID:38197464
IL-38 alleviates atherogenic responses via SIRT6/HO-1 signaling: A promising strategy against obesity-related atherosclerosis., PMID:38154209
Predicting perinatal outcomes in women affected by COVID-19: An artificial intelligence (AI) approach., PMID:38107716
Deciphering the Function of New Therapeutic Targets and Prospective Biomarkers in the Management of Psoriasis., PMID:38037998
IL-38 regulates intestinal stem cell homeostasis by inducing WNT signaling and beneficial IL-1β secretion., PMID:37906644
Ameliorated Renal Pathological Feature in MRL/MpJ-Faslpr/lpr Background Interleukin-36 Receptor-Deficient Mice., PMID:37749712
Interleukin-38 and Insulin Resistance., PMID:37702180
The emerging role of IL-38 in diseases: A comprehensive review., PMID:37647430
IL-38 alleviates airway remodeling in chronic asthma via blocking the profibrotic effect of IL-36γ., PMID:37586814
IL-38 suppresses macrophage M1 polarization to ameliorate synovial inflammation in the TMJ via GLUT-1 inhibition., PMID:37463548
Interleukin-38: A crucial player in periodontitis., PMID:37455397
For research use only. Not for human or drug use.
