Catalog No.
AHN02401
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of human breast cancer cells (BT‑20). When 5 x 10^4 cells/well are added to rhJAML (Cat #: AHN02401) coated plates (10 µg/mL, 100 µL/well), approximately 55%-75% will adhere after 1 hour at 37 ℃. Similar results were obtained using HeLa, A549, and T84 cell-lines.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu10-Leu265
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86YT9
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dendritic cell-specific protein CREA7-1, Adhesion molecule interacting with CXADR antigen 1, Junctional adhesion molecule-like, AMICA1, JAML
Targeted activation of junctional adhesion molecule-like protein+ CD8+ T cells enhances immunotherapy in hepatocellular carcinoma., PMID:40353078
Sex Differences in Cerebrospinal Fluid Proteomics of Patients with Restless Legs Syndrome., PMID:40289925
Macrophage junctional adhesion molecule-like (JAML) protein promotes NLRP3 inflammasome activation in the development of atherosclerosis., PMID:40148467
Targeting JAML promotes normalization of tumour blood vessels to antagonize tumour progression via FAK/SRC and VEGF/VEGFR2 signalling pathways., PMID:39983824
In Situ Detection of Programmed Cell Death Protein 1 and Programmed Death Ligand 1 Interactions as a Functional Predictor for Response to Immune Checkpoint Inhibition in NSCLC., PMID:39743139
JAML overexpressed in colorectal cancer promotes tumour proliferation by activating the PI3K-AKT-mTOR signalling pathway., PMID:39424882
[Appropriate use of the ELN guidelines based on results of real-world genetic analysis in Japanese patients with AML]., PMID:39098019
JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment., PMID:38625487
JAML promotes the antitumor role of tumor-resident CD8+ T cells by facilitating their innate-like function in human lung cancer., PMID:38570084
The junctional adhesion molecule-like protein (JAML) is important for the inflammatory response during contact hypersensitivity., PMID:37619972
Beta-subunit-eliminated eHAP expression (BeHAPe) cells reveal subunit regulation of the cardiac voltage-gated sodium channel., PMID:37544648
Junctional adhesion molecule-like protein as a novel target for kaempferol to ameliorate lung adenocarcinoma., PMID:37069006
JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells., PMID:36701231
A Functional Network Driven by MicroRNA-125a Regulates Monocyte Trafficking in Acute Inflammation., PMID:36142632
JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism., PMID:35708906
Junctional adhesion molecule-like protein promotes tumor progression via the Wnt/β-catenin signaling pathway in lung adenocarcinoma., PMID:35672776
AMICA1 is a diagnostic and prognostic biomarker and induces immune cells infiltration by activating cGAS-STING signaling in lung adenocarcinoma., PMID:35248033
Resveratrol ameliorates diabetic kidney injury by reducing lipotoxicity and modulates expression of components of the junctional adhesion molecule-like/sirtuin 1 lipid metabolism pathway., PMID:35090936
Junctional Adhesion Molecule-Like Protein (JAML) Is Correlated with Prognosis and Immune Infiltrates in Lung Adenocarcinoma., PMID:35034089
JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy., PMID:34427588
RNA Sequencing of CD4+ T Cells in Relapsing-Remitting Multiple Sclerosis Patients at Relapse: Deciphering the Involvement of Novel genes and Pathways., PMID:34286457
Hspa8 and ICAM-1 as damage-induced mediators of γδ T cell activation., PMID:33847413
Junctional Adhesion Molecule-Like Protein Promotes Tumor Progression and Metastasis via p38 Signaling Pathway in Gastric Cancer., PMID:33777731
PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4+ T Cells., PMID:33763075
The JmjC-domain protein NO66/RIOX-1 affects the balance between proliferation and maturation in acute myeloid leukemia., PMID:33745927
Granulosa cell genes that regulate ovarian follicle development beyond the antral stage: The role of estrogen receptor β., PMID:33676987
Lipid Metabolism Gets in a JAML during Kidney Disease., PMID:33264600
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism., PMID:33186558
Infliximab treatment in pathology-confirmed neurosarcoidosis., PMID:32718952
Un-JAMming atherosclerotic arteries: JAM-L as a target to attenuate plaque development., PMID:31331991
Silencing of junctional adhesion molecule-like protein attenuates atherogenesis and enhances plaque stability in ApoE-/- mice., PMID:31101724
Junctional adhesion molecules mediate transendothelial migration of dendritic cell vaccine in cancer immunotherapy., PMID:30055289
TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers., PMID:27193388
Transforming growth factor β2 promotes transcription of COX2 and EP4, leading to a prostaglandin E2-driven autostimulatory loop that enhances virulence of Theileria annulata-transformed macrophages., PMID:25690101
Neutrophil-derived JAML inhibits repair of intestinal epithelial injury during acute inflammation., PMID:24621992
Chronic ethanol feeding induces subset loss and hyporesponsiveness in skin T cells., PMID:24512045
cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG lambda light chain antibody stimulatory for γδ T cells., PMID:21629689
JAML and CAR: two more players in T-cell activation., PMID:21566459
Searching for "signal 2": costimulation requirements of γδ T cells., PMID:21541698
Molecular insights into γδ T cell costimulation by an anti-JAML antibody., PMID:21220118
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K., PMID:20813955
The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation., PMID:20813954
JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation., PMID:19064666
Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration., PMID:18948633
Coxsackievirus and adenovirus receptor is up-regulated in migratory germ cells during passage of the blood-testis barrier., PMID:17690169
Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils., PMID:15800062
JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells., PMID:12869515
For research use only. Not for human or drug use.
