Catalog No.
AHN01801
Biological activity
Measured by its ability to induce Top flash reporter activity in human embryonic kidney cells (HEK293T). The typical ED50 is 0.7-2.8 ng/mL in the presence of 5 ng/mL recombinant mouse Wnt-3a.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln22-Gly205
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6UXX9
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Roof plate-specific spondin-2, R-spondin-2, hRspo2, RSPO2
The impact of an RNA-binding protein group on regulating the RSPO-LGR4/5-ZNRF3/RNF43 module and the immune microenvironment in hepatocellular carcinoma., PMID:40264052
Screening, expression, and functional validation of camelid-derived nanobodies targeting RSPO2., PMID:40179630
Anaplastic lymphoma kinase enhances Wnt signaling through R-spondin: A new dimension to ALK-mediated oncogenesis., PMID:40132715
Prognostic Biomarkers in Breast Cancer via Multi-Omics Clustering Analysis., PMID:40076569
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/β-catenin signaling., PMID:39753551
Cushing's Disease Manifestation in USP8-Mutated Corticotropinoma May Be Mediated by Interactions Between WNT Signaling and SST Trafficking., PMID:39684597
Gonadal transcriptome analysis of Opsariichthys bidens reveals sex-associated genes., PMID:39667087
Simulated microgravity environment inhibits matrix mineralization during the osteoblast to osteocyte differentiation., PMID:39550861
[Role of R-spondin 2 on osteogenic differentiation of bone marrow mesenchymal stem cells and bone metabolism in ovariectomized mice]., PMID:39542634
RSPO/LGR signaling regulates proliferation of adult hippocampal neural stem cells., PMID:39432578
An "R-spondin code" for multimodal signaling ON-OFF states., PMID:39180250
Clinical implications of Wnt pathway genetic alterations in men with advanced prostate cancer., PMID:39019980
Characterization of Wnt Signaling Pathway Aberrations in Metastatic Prostate Cancer., PMID:38912907
Identification of Rare EIF3E::RSPO2 Fusion in Recurrent and Aggressive Urachal Adenocarcinoma., PMID:38884183
Targeted protein degradation systems to enhance Wnt signaling., PMID:38847394
KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3., PMID:38758792
Multiomics data identifies RSPO2 as a prognostic biomarker in human tumors associated with pan-cancer., PMID:38448143
Role of the NF-kB signalling pathway in heterotopic ossification: biological and therapeutic significance., PMID:38439078
R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient., PMID:38307837
Calcitriol ameliorates motor deficits and prolongs survival of Chrne-deficient mouse, a model for congenital myasthenic syndrome, by inducing Rspo2., PMID:38233267
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/β-catenin pathway., PMID:37946278
RSPO2 as Wnt signaling enabler: Important roles in cancer development and therapeutic opportunities., PMID:37692504
CRISPR/dCAS9-mediated DNA demethylation screen identifies functional epigenetic determinants of colorectal cancer., PMID:37612734
Effect of Exogenous Hormone on R-Spondin 2 (Rspo2) and R-Spondin 3 (Rspo3) Gene Expression and Embryo Development in Chinese Soft-Shelled Turtle (Pelodiscus sinensis)., PMID:37510371
Rspo2-LGR4 exacerbates hepatocellular carcinoma progression via activation of Wnt/β-catenin signaling pathway., PMID:37437654
LGR4 and LGR5 form distinct homodimers that only LGR4 complexes with RNF43/ZNRF3 to provide high affinity binding of R-spondin ligands., PMID:37402772
Astaxanthin prevents osteoarthritis by blocking Rspo2-mediated Wnt/β-catenin signaling in chondrocytes and abolishing Rspo2-related inflammatory factors in macrophages., PMID:37354487
ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation., PMID:37321224
Effect of LGR4/EGFR signaling on cell growth and cancer stem cell-like characteristics in liver cancer., PMID:37001327
Genes critical for development and differentiation of dopaminergic neurons are downregulated in Parkinson's disease., PMID:36820885
Cartilage oligomeric matrix protein acts as a molecular biomarker in multiple cancer types., PMID:36255654
Suppression of Wnt/β-Catenin Signaling Is Associated with Downregulation of Wnt1, PORCN, and Rspo2 in Alzheimer's Disease., PMID:36215026
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis., PMID:36175067
Define the Two Molecular Subtypes of Epithelioid Malignant Pleural Mesothelioma., PMID:36139498
R-spondin-3 is an oncogenic driver of poorly differentiated invasive breast cancer., PMID:36106661
The role of roof plate-specific spondins in liver homeostasis and disease., PMID:39958194
RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification., PMID:35984875
Genomic Features of Organ-Specific Metastases in Lung Adenocarcinoma., PMID:35912232
A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice., PMID:35816602
Clinicopathological and molecular characteristics of RSPO fusion-positive colorectal cancer., PMID:35715628
Robust Colonic Epithelial Regeneration and Amelioration of Colitis via FZD-Specific Activation of Wnt Signaling., PMID:35569814
Comprehensive genetic characterization of rectal cancer in a large cohort of Japanese patients: differences according to tumor location., PMID:35449312
R-Spondin2, a Positive Canonical WNT Signaling Regulator, Controls the Expansion and Differentiation of Distal Lung Epithelial Stem/Progenitor Cells in Mice., PMID:35328508
A simple method to generate human airway epithelial organoids with externally orientated apical membranes., PMID:35080188
Tracing the Origin of the RSPO2 Long-Hair Allele and Epistatic Interaction between FGF5 and RSPO2 in Sapsaree Dog., PMID:35052442
Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd., PMID:35032551
Identification of a regulatory pathway inhibiting adipogenesis via RSPO2., PMID:35027768
Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson's disease., PMID:34941945
WNT11, a new gene associated with early onset osteoporosis, is required for osteoblastogenesis., PMID:34875064
Candidate positive targets of LHX6 and LHX8 transcription factors in the developing upper jaw., PMID:34861428
For research use only. Not for human or drug use.
