Catalog No.
AHB96501
Biological activity
Measured by its binding ability in a functional ELISA. Immobilized rhLayilin at 5 µg/mL (100 µL/well) can bind biotinylated hyaluronan with a linear range of 0.8-50 µg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala22-Lys220
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6UX15
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LAYN, Layilin
Characterization of Exhausted T Cell Signatures in Pan-Cancer Settings., PMID:40076932
Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome-Wide Mendelian Randomization and Colocalization Analysis., PMID:40026415
Potential drug targets for asthma identified through mendelian randomization analysis., PMID:39806440
De novo biosynthesis of mogroside V by multiplexed engineered yeasts., PMID:39788182
Role of layilin in regulating mitochondria-mediated apoptosis: a study on B cell lymphoma (BCL)-2 family proteins., PMID:39455917
Evaluation of circulating plasma proteins in prostate cancer using mendelian randomization., PMID:39287922
Mendelian randomization reveals potential causal relationships between cellular senescence-related genes and multiple cancer risks., PMID:39215079
Neurological-related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity., PMID:39075931
Prostaglandin D2 receptor 2 downstream signaling and modulation of type 2 innate lymphoid cells from patients with asthma., PMID:39052598
Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy., PMID:39048581
Associations between multiple neurological biomarkers and distal sensorimotor polyneuropathy: KORA F4/FF4 study., PMID:38872492
Integrative single-cell analysis of LUAD: elucidating immune cell dynamics and prognostic modeling based on exhausted CD8+ T cells., PMID:38596689
Identification of potential drug targets for allergic diseases from a genetic perspective: A mendelian randomization study., PMID:38573314
Assessment of Anti-Inflammatory and Antioxidant Activities of a Proprietary Preparation of Quercetin-Rutin Blend (SophorOx™) in Exercised Rats., PMID:38371227
Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation., PMID:37996402
Elevated Layilin-Positive Monocyte Levels in the Peripheral Blood of Patients with Systemic Lupus Erythematosus Reflect Their Autoimmune Status., PMID:37642473
Comprehensive landscape of the miRNA-regulated prognostic marker LAYN with immune infiltration and stemness in pan-cancer., PMID:37335337
The MIR34B/C genomic region contains multiple potential regulators of multiciliogenesis., PMID:37102425
Targeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharides., PMID:36805871
ncRNA-Regulated LAYN Serves as a Prognostic Biomarker and Correlates with Immune Cell Infiltration in Hepatocellular Carcinoma: A Bioinformatics Analysis., PMID:36398067
Low-dose anti-VEGFR2 therapy promotes anti-tumor immunity in lung adenocarcinoma by down-regulating the expression of layilin on tumor-infiltrating CD8+T cells., PMID:36260222
Results of untargeted analysis using the SOMAscan proteomics platform indicates novel associations of circulating proteins with risk of progression to kidney failure in diabetes., PMID:35618095
Proteomics-Based Serum Alterations of the Human Protein Expression after Out-of-Hospital Cardiac Arrest: Pilot Study for Prognostication of Survivors vs. Non-Survivors at Day 1 after Return of Spontaneous Circulation (ROSC)., PMID:35207267
Assessment of anti-inflammatory and antioxidant activity of quercetin-rutin blend (SophorOx™) - an invitro cell based assay., PMID:35179009
The regulatory effect of hyaluronan on human mesenchymal stem cells' fate modulates their interaction with cancer cells in vitro., PMID:34707175
Layilin Anchors Regulatory T Cells in Skin., PMID:34470859
Layilin promotes mitochondrial fission by cyclin-dependent kinase 1 and dynamin-related protein 1 activation in HEK293T cells., PMID:33676182
Increased IGFBP7 Expression Correlates with Poor Prognosis and Immune Infiltration in Gastric Cancer., PMID:33531979
Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs., PMID:32809975
Layilin augments integrin activation to promote antitumor immunity., PMID:32539073
Intake of Ganoderma lucidum polysaccharides reverses the disturbed gut microbiota and metabolism in type 2 diabetic rats., PMID:31712153
Understanding tumor-infiltrating lymphocytes by single cell RNA sequencing., PMID:31699218
Specifically Sized Hyaluronan (35 kDa) Prevents Ethanol-Induced Disruption of Epithelial Tight Junctions Through a layilin-Dependent Mechanism in Caco-2 Cells., PMID:31237689
Layilin enhances the invasive ability of malignant glioma cells via SNAI1 signaling., PMID:31145904
LAYN Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric and Colon Cancers., PMID:30761122
Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice., PMID:30060618
Anti-Inflammatory Effects of Intra-Articular Hyaluronic Acid: A Systematic Review., PMID:29429372
Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1α Promoter Activity., PMID:28448136
Transcriptome profiling of human FoxP3+ regulatory T cells., PMID:26686412
Roles of layilin in TNF-α-induced epithelial-mesenchymal transformation of renal tubular epithelial cells., PMID:26410531
Secretion of inflammatory factors from chondrocytes by layilin signaling., PMID:25150153
Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin., PMID:23048036
Layilin, a talin-binding hyaluronan receptor, is expressed in human articular chondrocytes and synoviocytes and is down-regulated by interleukin-1β., PMID:22722918
An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence., PMID:21740549
For research use only. Not for human or drug use.
