Catalog No.
AMG84901
Biological activity
Measured in a cell proliferation assay using mouse plasmacytoma cells (T11). The ED50 for this effect is 0.5-2 µg/mL in the presence of 0.75 ng/mL recombinant Mouse IL‑11.
Expression system
Mammalian Cells
Species
Mus musculus (Mouse)
Protein length
Met1-Gln367
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q64385
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-11RA, sIL-11R, Interleukin-11 receptor subunit alpha, sIL-11RA, IL11RA, IL-11R-alpha, IL-11R subunit alpha, IL-11 receptor subunit alpha, sIL11RA
Interleukin 11 therapy causes acute left ventricular dysfunction., PMID:39383190
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan., PMID:39020175
ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice., PMID:38443404
Nanoparticle-Mediated RNA Therapy Attenuates Nonalcoholic Steatohepatitis and Related Fibrosis by Targeting Activated Hepatic Stellate Cells., PMID:37490628
Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells., PMID:37012048
IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome., PMID:36924234
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease., PMID:36470928
A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome., PMID:35140116
Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome., PMID:35135328
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts., PMID:34651016
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis., PMID:34239012
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury., PMID:34108253
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer., PMID:33863879
Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload., PMID:33462828
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH., PMID:33397952
Colitis-induced IL11 promotes colon carcinogenesis., PMID:33196831
Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease., PMID:32656894
IL-11 in cardiac and renal fibrosis: Late to the party but a central player., PMID:32022251
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis., PMID:31554736
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis., PMID:31078624
IL-11 is a crucial determinant of cardiovascular fibrosis., PMID:29160304
Critical Contribution of Nuclear Factor Erythroid 2-related Factor 2 (NRF2) to Electrophile-induced Interleukin-11 Production., PMID:27872193
Cytotoxicity and gene expression in sarcoma 180 cells in response to spiky magnetoplasmonic supraparticles., PMID:25369231
Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury., PMID:22715999
IL-11 regulates autoimmune demyelination., PMID:19734214
The interleukin-6 family cytokine interleukin-11 regulates homeostatic epithelial cell turnover and promotes gastric tumor development., PMID:19121317
Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice., PMID:17881769
Effect of recombinant human interleukin-11 on expressions of interleukin-11 receptor alpha-chain and glycoprotein 130 in intestinal epithelium cell line-6 after neutron irradiation., PMID:16718787
Interleukin-11, IL-11 receptoralpha and leukemia inhibitory factor are dysregulated in endometrium of infertile women with endometriosis during the implantation window., PMID:16310857
Interleukin-11 receptor signaling is required for normal bone remodeling., PMID:15940362
IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling., PMID:15699166
The production of interleukin-11 and decidualization are compromised in endometrial stromal cells derived from patients with infertility., PMID:15613426
Endogenous IL-11 is pro-inflammatory in acute methylated bovine serum albumin/interleukin-1-induced (mBSA/IL-1)arthritis., PMID:15598441
Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor alpha deficient mice., PMID:15537430
Interleukin-11 signaling is required for the differentiation of natural killer cells at the maternal-fetal interface., PMID:15499555
Interleukin-11 expression: its significance in eutopic and ectopic human implantation., PMID:15465850
Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells., PMID:14701802
Determinants of iodothyronine deiodinase activities in rodent uterus., PMID:12959985
Characterization of a potent human interleukin-11 agonist., PMID:12919066
Functional characterization of W147A: a high-affinity interleukin-11 antagonist., PMID:12865319
The regulation of adipocyte metabolism and gene expression by interleukin-11., PMID:12791389
IL-11 and IL-11Ralpha immunolocalisation at primate implantation sites supports a role for IL-11 in placentation and fetal development., PMID:12740032
Interleukin-11-induced heat shock protein 25 confers intestinal epithelial-specific cytoprotection from oxidant stress., PMID:12730876
Expression and function of interleukin-11 and its receptor alpha in the human endometrium., PMID:12569176
Cytokine receptor repertoire and cytokine responsiveness of Ho(dull)/Rh(dull) stem cells with differing potentials for G1/S phase progression., PMID:12135678
IL-11: insights in asthma from overexpression transgenic modeling., PMID:11590369
Cloning of rat interleukin 11 and interleukin 11 receptor alpha chain and analysis of their expression in rat uterus in the peri-implantation period., PMID:11570967
Genes involved in implantation., PMID:11545164
Lack of expression of Gp-130 makes pancreatic beta cell lines unresponsive to the IL-6 family of cytokines., PMID:11467415
Interleukin-11 modulates Th1/Th2 cytokine production from activated CD4+ T cells., PMID:11177577