Catalog No.
AHJ03701
Biological activity
Immobilized human IL-12B & IL-23A at 5μg/mL (100 μL/well) can bind human IL23R (Cat #: AHJ03701) with a linear range of 4-135 ng/ml.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly24-Gly355
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5VWK5
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-23R, IL-23 receptor, IL23R, Interleukin-23 receptor
Serum proteomic and metabolomic analyses from patients with IBD identify biological pathways associated with treatment success with anti-integrin therapy., PMID:40509637
STAT3 inhibition mitigates experimental autoimmune gastritis by restoring Th17/Treg immune balance., PMID:40471463
Identification of novel drug targets through integrative PWAS of brain and plasma proteins with Ulcerative Colitis GWAS., PMID:40446056
Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling., PMID:40434646
Targeting the IL-23 Receptor Gene: A Promising Approach in Inflammatory Bowel Disease Treatment., PMID:40429917
A hybrid protocol for peptide development: integrating deep generative models and physics simulations for biomolecular design targeting IL23R/IL23., PMID:40419055
Mendelian randomization analysis identifies ERAP1 and IL23R as potential drug targets for ankylosing spondylitis., PMID:40349828
Multiplex immunofluorescence assessment of macrophages and IL-23R in inflammatory and malignant diseases of the oral mucosa: a pilot study., PMID:40297579
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis., PMID:40091833
GWAS identifies genetic loci, lifestyle factors and circulating biomarkers that are risk factors for sarcoidosis., PMID:40075078
STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis., PMID:40042874
The Causal Relationships and Therapeutic Targets of Plasma Proteins in Ankylosing Spondylitis., PMID:40002719
An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis., PMID:39953266
Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans., PMID:39923740
Pharmacogenomic insights: IL-23R and ATG-10 polymorphisms in Sorafenib response for hepatocellular carcinoma., PMID:39921803
IL-17A, IL-23R, FCGR3A are associated with neuropsychiatric systemic lupus erythematosus susceptibility in pediatric patients with lupus nephritis., PMID:39904110
IL-23 Promotes γδT Cell Activity in Dry Eye Disease Progression., PMID:39903182
Genetic Variants of the IL-23/IL-17 Axis and Its Association With Periodontal Disease: A Systematic Review., PMID:39887950
Replication Study and Meta-Analysis of the Contribution of Seven Genetic Polymorphisms in Immune-Related Genes to the Risk of Gastric and Colorectal Cancers., PMID:39800859
IL-23R is a senescence-linked circulating and tissue biomarker of aging., PMID:39658621
Therapeutic targets for gastrointestinal diseases: proteome-wide Mendelian randomization and colocalization analyses., PMID:39400547
A pilot study to identify blood-based markers associated with response to treatment with Vedolizumab in patients with Inflammatory Bowel Disease., PMID:39371119
IL23R mutations associated with decreased risk of psoriasis lead to the differential expression of genes implicated in the disease., PMID:39306854
Malassezia globosa Induces Differentiation of Pathogenic Th17 Cells by Inducing IL-23 Secretion by Keratinocytes., PMID:39283337
Exploring causal correlations between plasma proteins and peripheral neuropathy: a Mendelian randomization., PMID:39268072
IL23R-Specific CAR Tregs for the Treatment of Crohn's Disease., PMID:39252592
Intermittent Fasting-Induced Orm2 Promotes Adipose Browning via the GP130/IL23R-p38 Cascade., PMID:39248328
Association between interleukin-12 p40 subunit and risk of primary Sjögren's disease: a Mendelian randomization study., PMID:39222420
Case-control study of IL23R rs76418789 polymorphism, smoking, and ulcerative colitis in Japan., PMID:39213891
Investigating potential novel therapeutic targets and biomarkers for ankylosing spondylitis using plasma protein screening., PMID:39185422
GSK805 inhibits alpha-smooth muscle expression and modulates liver inflammation without impairing the well-being of mice., PMID:39157975
Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization., PMID:39144148
Homocysteine Promotes Intestinal Inflammation in Colitis Mice Through the PGE2/STAT3 Signaling Pathway., PMID:39141200
RIPK3 and caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut., PMID:39137882
JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans., PMID:39080319
Illuminating the impact of γδ T cells in man and mice in spondylarthritides., PMID:39077953
Interaction of Th17 differentiations-related gene polymorphisms and environmental factors contributing to the disease classification, complications, and surgical risks of Crohn's disease in the Chinese Han population., PMID:39075019
Renal IL-23-Dependent Type 3 Innate Lymphoid Cells Link Crystal-induced Intrarenal Inflammasome Activation with Kidney Fibrosis., PMID:39072698
IL-6 induces Treg dysfunction in desiccating stress-induced dry eye disease., PMID:39009059
Paradoxical Psoriasis in Patients Receiving Therapy with Tumor Necrosis Factor Inhibitors: Potential Pathogenic Mechanisms and the Role of Genetic Factors., PMID:39000125
Preclinical proof of principle for orally delivered Th17 antagonist miniproteins., PMID:38936360
Genetic overlap between psoriatic arthritis and ankylosing spondylitis in a Chinese population., PMID:38907550
Genetic associations in ankylosing spondylitis: circulating proteins as drug targets and biomarkers., PMID:38835753
BATF-dependent Th17 cells act through the IL-23R pathway to promote prostate adenocarcinoma initiation and progression., PMID:38833676
Intestinal CXCR6+ ILC3s migrate to the kidney and exacerbate renal fibrosis via IL-23 receptor signaling enhanced by PD-1 expression., PMID:38815582
Dietary mercury intake, the IL23R rs10889677 polymorphism, and the risk of gastric cancer in a Korean population: a hospital-based case-control study., PMID:38810984
Psoriasis and Psoriatic Arthritis-Associated Genes, Cytokines, and Human Leukocyte Antigens., PMID:38792999
Insights into Therapeutic Response Prediction for Ustekinumab in Ulcerative Colitis Using an Ensemble Bioinformatics Approach., PMID:38791570
IL23R G149R Promotes IL-23 Unresponsiveness in Human Memory Th17 Cells., PMID:38548259
Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-α and IL-23p19 bioactivities., PMID:38533646
For research use only. Not for human or drug use.
