Catalog No.
AHE25701
Biological activity
Immobilized human CD155/PVR at 2 μg/ml (100 μl/well) can bind human CD96 (Cat #: AHE25701), the EC50 of human CD96 is 200-800 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Val22-Met503
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P40200
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cell surface antigen CD96, T cell-activated increased late expression protein, CD96, T-cell surface protein tactile
Predictors of Immunogenicity and Loss of Response to ANTI-TNFα Therapy in Crohn Disease-A Systematic Review., PMID:40338684
CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma., PMID:40234092
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis., PMID:40091833
PVR exposure influences the activation, adhesion, and protein expression of human CD8+ T cells, including the CD96-mediated transfer of PVR., PMID:40073261
CD96: immunoregulation and its role and prospect in immunotherapy of primary hepatocellular carcinoma., PMID:39976070
Therapeutic drug monitoring and immunogenetic factors associated with the use of adalimumab in Crohn's disease patients., PMID:39959979
CD96 enhances the anti-viral activity of natural killer cells by promoting Ly49H-mediated activation during mouse cytomegalovirus infection., PMID:39923661
CD155 promotes the advancement of hepatocellular carcinoma by suppressing the p53-mediated ferroptosis via interacting with CD96., PMID:39878917
Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy., PMID:39871281
Recognition of Self and Viral Ligands by NK Cell Receptors., PMID:39748148
Immune-based subgroups uncover diverse tumor immunogenicity and implications for prognosis and precision therapy in acute myeloid leukemia., PMID:39582863
A study of the association of vitamin D receptor (VDR) as a predictive biomarker for immune checkpoint inhibitor therapy with immune invasion in colon adenocarcinoma., PMID:39378759
Time series analysis combined with transcriptome sequencing to explore characteristic genes and potential molecular mechanisms associated with ultrasound-guided microwave ablation of glioma., PMID:39317933
Upregulation of HSD11B1 promotes cortisol production and inhibits NK cell activation in pancreatic adenocarcinoma., PMID:39276709
Unraveling the origins of pathogenic CXCL13+ helper T cells in systemic lupus erythematosus., PMID:39218440
Prognostic impact of enhanced CD96 expression on NK cells by TGF-β1 in AML., PMID:39159564
Aspirin Inhibits Colorectal Cancer via the TIGIT-BCL2-BAX pathway in T Cells., PMID:39113892
Interferon subverts an AHR-JUN axis to promote CXCL13+ T cells in lupus., PMID:38987586
Cytoplasmic Lipid Droplets Predict Worse Prognosis in Diffuse Large B-Cell Lymphoma: Next-Generation Sequencing Deciphering Lipogenic Genes., PMID:38979928
The Immune Checkpoint BTLA in Oral Cancer: Expression Analysis and Its Correlation to Other Immune Modulators., PMID:38928307
Platelet-mediated circulating tumor cell evasion from natural killer cell killing through immune checkpoint CD155-TIGIT., PMID:38779918
Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2., PMID:38626767
Immune checkpoints in autoimmune vasculitis., PMID:38599937
CD155 as an emerging target in tumor immunotherapy., PMID:38518596
Combining TIGIT blockade with IL-15 stimulation is a promising immunotherapy strategy for lung adenocarcinoma., PMID:38279870
CRISPR-Cas9-Based Gene Knockout of Immune Checkpoints in Expanded NK Cells., PMID:38003255
ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4., PMID:37964351
Poliovirus receptor-based chimeric antigen receptor T cells combined with NK-92 cells exert potent activity against glioblastoma., PMID:37944044
[CD226, TIGIT and CD96 regulate NK cell function and participate in anti-tumor immunity]., PMID:37732582
Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT., PMID:37675979
Single-cell analysis of human prepuce reveals dynamic changes in gene regulation and cellular communications., PMID:37658288
AKT inhibition interferes with the expression of immune checkpoint proteins and increases NK-induced killing of HL60-AML cells., PMID:37341216
Deficiency of the CD155-CD96 immune checkpoint controls IL-9 production in giant cell arteritis., PMID:37075705
The Immune Checkpoint Receptor CD96: A Local and Systemic Immune Modulator in Oral Cancer?, PMID:37046787
High dimensional analysis reveals distinct NK cell subsets but conserved response to stimulation in umbilical cord blood and adult peripheral blood., PMID:37025016
CD44, CD90 and CD96 expression in immune thrombocytopenia purpura (ITP) patients., PMID:36949573
The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity., PMID:36944702
Screening of potential immune-related genes expressed during sepsis using gene sequencing technology., PMID:36918563
Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease., PMID:36860353
The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells., PMID:36845105
The Differentially Expressed Genes Responsible for the Development of T Helper 9 Cells From T Helper 2 Cells in Various Disease States: Immuno-Interactomics Study., PMID:38935935
The new oncogene transmembrane protein 60 is a potential therapeutic target in glioma., PMID:36744183
CD96 as a Potential Immune Regulator in Cancers., PMID:36674817
An Inhibitory Role for Human CD96 Endodomain in T Cell Anti-Tumor Responses., PMID:36672244
[MiR-4772 modulates tumor immune microenvironment by regulating immune- related genes in ovarian cancer]., PMID:36504056
High-Throughput and Efficient Intracellular Delivery Method via a Vibration-Assisted Nanoneedle/Microfluidic Composite System., PMID:36479877
Differentially Infiltrated Identification of Novel Diagnostic Biomarkers Associated with Immune Infiltration in Nasopharyngeal Carcinoma., PMID:36438903
A novel ten-gene prognostic signature for cervical cancer based on CD79B-related immunomodulators., PMID:36406115
CD4+IL9+ (Th9) cells as the major source of IL-9, potentially modulate Th17/Treg mediated host immune response during experimental cerebral malaria., PMID:36395532
Prognostic value of tumor-infiltrating immune cells and immune checkpoints in elderly head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiotherapy., PMID:36376922
For research use only. Not for human or drug use.
