Catalog No.
AHE24701
Biological activity
Measured by its ability to cleave the fluorogenic peptide substrate, McaPLGL-Dpa-ARNH2. The specific activity is >800 pmol/min/μg.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly106-Asn268
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P39900
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Macrophage elastase, HME, ME, MMP12, Matrix metalloproteinase-12, MME, hME, MMP-12, Macrophage metalloelastase
Mefunidone treats pulmonary fibrosis by targeting SDH to regulate fibro-promoting macrophages., PMID:40449267
Proteomic insights into COPD pathogenesis and therapeutic targets: a causal analysis of circulating proteins., PMID:40421300
Sequence and Structure at Play in Designing Allosteric Drugs and Alleviating the Drug Resistance., PMID:40378916
Calceolarioside B targets MMP12 in the tumor microenvironment to inhibit M2 macrophage polarization and suppress hepatocellular carcinoma progression., PMID:40347889
Differential effects of tofacitinib on macrophage activation contribute to lack of response in ulcerative colitis patients., PMID:40320713
Proteome-Wide Genetic Study in East Asians and Europeans Identified Multiple Therapeutic Targets for Ischemic Stroke., PMID:40304040
Structure characterization and protective effect against UVB irradiation of polysaccharides isolated from the peach gums., PMID:40294685
Single-cell and spatial transcriptomics reveal the pathogenesis of chronic granulomatous disease in a natural model., PMID:40272982
Longitudinal changes in blood-borne geroscience biomarkers: results from a population-based study., PMID:40272732
Correlation of the Expression Profile of Peripheral Leukocyte and Liver Tissue Immune Markers With Serum Liver Injury Indices in Children With Biliary Atresia., PMID:40270513
Interleukin-1β Inhibits Ovarian Cancer Cell Proliferation and Metastasis Through the MAPK/MMP12 Pathway., PMID:40244135
Salidroside inhibits the invasion and migration of colorectal cancer cells by regulating MMP-12 and WNT signaling pathway., PMID:40226472
Impact of differentially expressed genes and proteins in donor arterial plaque on renal function recovery following allogeneic kidney transplantation., PMID:40226083
MMP12 deficiency attenuates menthol e-cigarette plus house dust-mite effects on pulmonary iron homeostasis and oxidative stress., PMID:40217328
Identification of Salivary Biomarkers in Colorectal Cancer by Integrating Olink Proteomics and Metabolomics., PMID:40183281
Respiratory symptoms, sensitisation and occupational exposure in the shrimp processing industry., PMID:40181810
In-silico study of rosmarinic acid roles in inhibiting breast cancer progression., PMID:40176865
Histological and transcriptomic analysis of paravaginal and central defects in anterior vaginal wall prolapse: Insights from DeLancey's pelvic floor theory., PMID:40171978
PLC and PAD2 Regulate Extracellular Calcium-Triggered Release of Macrophage Extracellular DNA Traps., PMID:40170382
Nootkatone (NK), a grapefruit-derived sesquiterpenoid, suppresses UVB-induced damage by regulating NRF2-HO-1 and AhR-CYP1A1 signaling pathways in HaCaT cells., PMID:40151610
CHI3L1: a key driver in gastritis-to-cancer transformation., PMID:40108688
The anti-atherosclerotic effect of chronic AT1 receptor blocker treatment also depends on the ACE2/Ang(1-7)/Mas axis., PMID:40106968
Unraveling the role of proteins in dementia: insights from two UK cohorts with causal evidence., PMID:40092369
Jatrorrhizine retard obesity by modulating transcription factor c-Jun/c-Fos to downregulate Mmp12-mediated inflammation., PMID:40086054
Identifying Circulating Protein Mediators in the Link Between Smoking and Abdominal Aortic Aneurysm: An Integrated Analysis of Human Proteomic and Genomic Data., PMID:40061319
MMP12-dependent myofibroblast formation contributes to nucleus pulposus fibrosis., PMID:40036084
Matrix metalloproteinases and their tissue inhibitors as upcoming biomarker signatures of connective tissue diseases-related interstitial lung disease: towards an earlier and accurate diagnosis., PMID:39979794
Matrix metalloproteinase-12, an indicator potentially contributing to the differential diagnosis and activity assessment of retroperitoneal fibrosis., PMID:39977006
Activation of the NF-κB signaling pathway by Reynoutria japonica Houtt ameliorates complete Freund's adjuvant-induced arthritis in rats., PMID:39971820
Dipeptidyl peptidase-4 deficiency prevents chronic stress-induced cardiac remodeling and dysfunction in mice., PMID:39968759
Simultaneous Detection of MMP-1 and MMP-12 Using Au-Se Nanoprobe for Advancing NSCLC Diagnosis., PMID:39967032
The roles of HOXB9 and MMP12 in proliferation, migration, and invasion of human laryngeal cancer cells LCC and TU212., PMID:39938450
Diosgenin-Loaded Silver Nanoparticles Mitigate B[a]P-Induced Lung Fibrosis Through Modulation of Oxidative Stress and Inflammatory Pathways., PMID:39901680
Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage., PMID:39891210
Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking., PMID:39884015
CIDEC/FSP27 exacerbates obesity-related abdominal aortic aneurysm by promoting perivascular adipose tissue inflammation., PMID:39872985
Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome., PMID:39858399
Genetic diversity leads to differential inflammatory responses to cigarette smoke in mice., PMID:39844449
Tissue degrading and remodelling molecules in giant cell arteritis., PMID:39837478
Cohesin Complex Interacting with Promoters of MMP Genes for in Pterygium Occurrence., PMID:39819270
Aligned membranes regulate wound healing via MMP12 secreted by macrophages., PMID:39813228
Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Their Ratios in Women with Polycystic Ovary Syndrome and Healthy Controls., PMID:39796177
Airway MMP-12 and DNA methylation in COPD: an integrative approach., PMID:39794761
Transcriptomic Characterization Reveals Mitochondrial Involvement in Nrf2/Keap1-Mediated Osteoclastogenesis., PMID:39765903
ADAMDEC1 promotes the malignant progression of cholangiocarcinoma by regulating NF-κB signaling pathway., PMID:39755752
Matrix metalloproteinase-12 by M2 macrophages induced epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyps., PMID:39739687
Shared Gene Expression Dysregulation Across Subtypes of Sanfilippo and Morquio Diseases: The Role of PFN1 in Regulating Glycosaminoglycan Levels., PMID:39735993
An overview of matrix metalloproteinase-12 in multiple disease conditions, potential selective inhibitors, and drug designing strategies., PMID:39709794
Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways., PMID:39694936
The regulatory role of BMP9 on lipopolysaccharide-induced matrix metalloproteinases in human stem cells from the apical papilla., PMID:39689436
For research use only. Not for human or drug use.
