Catalog No.
AHD61301
Biological activity
Measured by its ability to induce TNF alpha secretion by mouse monocyte/macrophage cells (RAW 264.7) under serum free conditions in the presence of muramyl dipeptide (MDP). The ED50 for this effect is less than 12 μg/mL.
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys2-Asn131
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P24001
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NK4, Tumor necrosis factor alpha-inducing factor, TAIF, IL32, Natural killer cells protein 4, IL-32, Interleukin-32
Rab7 inhibitor enhances stem cell differentiation into keratinocyte-like cells with anti-inflammatory properties., PMID:40491919
Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma., PMID:40487392
YTHDF3 regulates IL32 mRNA stability to promote osteogenic differentiation of bone mesenchymal stem cells in ankylosing spondylitis., PMID:40448194
Identification of potential key targets and mechanisms underlying cleft palate induced by tobacco smoke exposure through multi-omics integrated Mendelian randomization analysis., PMID:40435780
IL-32-producing CD8+ memory T cells define immunoregulatory niches in human cutaneous leishmaniasis., PMID:40371647
The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner., PMID:40329688
Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV., PMID:40214435
Overcoming immunotherapy resistance in colorectal cancer through nano-selenium probiotic complexes and IL-32 modulation., PMID:40081224
A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis., PMID:39939782
Analysis of effector/memory regulatory T cells from arrhythmogenic cardiomyopathy patients identified IL-32 as a novel player in ACM pathogenesis., PMID:39934117
Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma., PMID:39868576
Single-nucleotide polymorphisms in genes associated with the vitamin D pathway related to clinical and therapeutic outcomes of American tegumentary leishmaniasis., PMID:39844838
Exploring the Involvement of New Members of the Interleukin Family in Cardiovascular Disease., PMID:39844544
Impact of IL-32 gene polymorphisms on tuberculosis susceptibility in a Chinese Han population., PMID:39842733
Interleukin-32 positive immune and resident cells in kidney samples from lupus patients: a pilot study., PMID:39835128
Mutated IL-32θ (A94V) inhibits COX2, GM-CSF and CYP1A1 through AhR/ARNT and MAPKs/NF-κB/AP-1 in keratinocytes exposed to PM10., PMID:39814789
Therapeutic Ultrasound Modulates Cell Proliferation and Proinflammatory Cytokine Levels in Osteoarthritic Chondrocytes., PMID:39799470
Death-Associated Protein Kinase 1 Dampens Keratinocyte Necroptosis and Expression of Inflammatory Genes in Lichen Planus., PMID:39746570
Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response., PMID:39631069
Identification of the key targets for sepsis-associated acute kidney injury by RNA sequencing combined with bioinformatics methods., PMID:39616313
Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy., PMID:39572160
The impact of PTEN status on glioblastoma multiforme: A glial cell type-specific study identifies unique prognostic markers., PMID:39531927
IL-32γ Induced Autophagy Through Suppression of MET and mTOR Pathways in Liver Tumor Growth Inhibition., PMID:39519229
A novel genetic association of IL32 with tuberculosis., PMID:39442340
Pericytes Modulate Third-Generation Tyrosine Kinase Inhibitor Sensitivity in EGFR-Mutated Lung Cancer Cells Through IL32-β5-Integrin Paracrine Signaling., PMID:39435643
Transcriptome-wide RNA m6A methylation profiles in an endemic osteoarthropathy, Kashin-Beck disease., PMID:39428571
Enhanced Association of Novel Cardiovascular Biomarkers Fetuin-A and Catestatin with Serological and Inflammatory Markers in Rheumatoid Arthritis Patients., PMID:39337398
Time series analysis combined with transcriptome sequencing to explore characteristic genes and potential molecular mechanisms associated with ultrasound-guided microwave ablation of glioma., PMID:39317933
Research on key pathogenesis and potential intervention targets of idiopathic renal calculi composed of calcium oxalate (CaOx) based on bioinformatics., PMID:39280684
Characterization of pre- and on-treatment soluble immune mediators and the tumor microenvironment in NSCLC patients receiving PD-1/L1 inhibitor monotherapy., PMID:39235457
Elucidating the role of tumor-associated ALOX5+ mast cells with transformative function in cervical cancer progression via single-cell RNA sequencing., PMID:39224598
IL-2 and TCR stimulation induce expression and secretion of IL-32β by human T cells., PMID:39211051
IL-32 aggravates metabolic disturbance in human nucleus pulposus cells by activating FAT4-mediated Hippo/YAP signaling., PMID:39178518
mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes., PMID:39118084
IL-32 regulates trophoblast invasion through miR-205-NFκB-MMP2/9 axis contributing to the pregnancy-induced hypertension†., PMID:39101465
Identification and verification of immune-related genes for diagnosing the progression of atherosclerosis and metabolic syndrome., PMID:39095691
N-terminal cysteine acetylation and oxidation patterns may define protein stability., PMID:38918375
IL-32/NFκB/miR-205 loop sustains the high expression of IL-32 and enhances the motility of cervical cancer cells., PMID:38902566
Granuloma Annulare Exhibits Mixed Immune and Macrophage Polarization Profiles with Spatial Transcriptomics., PMID:38844128
Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19., PMID:38805808
The regulation and potential role of interleukin-32 in tuberculous pleural effusion., PMID:38803498
Unravelling the molecular landscape of endometrial cancer subtypes: insights from multiomics analysis., PMID:38775562
Assessment of serum inflammatory parameters in RRMS and SPMS patients., PMID:38697017
Integration analysis of single-cell transcriptome reveals specific monocyte subsets associated with melanoma brain and leptomeningeal metastasis., PMID:38616506
Ischemia-free liver transplantation improves the prognosis of recipients using functionally marginal liver grafts., PMID:38600871
Pan-cancer analysis reveals IL32 is a potential prognostic and immunotherapeutic biomarker in cancer., PMID:38584169
The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis., PMID:38420119
CSF levels of Chitinase3like1 correlate with early response to cladribine in multiple sclerosis., PMID:38404586
Effects of highly effective modulator therapy on the dynamics of the respiratory mucosal environment and inflammatory response in cystic fibrosis., PMID:38353361
ADGRE5-centered Tsurv model in T cells recognizes responders to neoadjuvant cancer immunotherapy., PMID:38343549
For research use only. Not for human or drug use.
