Catalog No.
AHD49401
Biological activity
Measured by its ability to induce alkaline phosphatase production by mouse chondrogenic cells (ATDC5). The ED50 for this effect is 0.2-1.2 µg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala317-His454
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P22003
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BMP-5, BMP5, Bone morphogenetic protein 5
BMP5 signalling in beta cells and the impact on insulin secretion in the context of type 2 diabetes., PMID:40471239
An atlas of early human mandibular endochondral and osteogenic paracrine signaling regions of Meckel's cartilage., PMID:40096606
Genome-wide identification, evolution, and expression analysis of the bone morphogenetic protein gene family in Myxocyprinus asiaticus., PMID:39893899
Ear pinna growth and differentiation is conserved in murids and requires BMP signaling for chondrocyte proliferation., PMID:39846506
Opposing roles for Bmp signalling during the development of electrosensory lateral line organs., PMID:39745052
Notch signaling mediates between two pattern-forming processes during head regeneration in Hydra., PMID:39532539
BMP5 promotes trophoblast functions upon N-glycosylation via the BMP5-SMAD1/5 signaling pathway in preeclampsia., PMID:39520832
BMP signaling pathway member expression is enriched in enteric neural progenitors and required for zebrafish enteric nervous system development., PMID:39297504
Compound heterozygosity for two variants in BMP5 in human skeletal dysostosis with atrioventricular septal defect., PMID:39239663
Establishing and Characterizing the Molecular Profiles, Cellular Features, and Clinical Utility of a Patient-Derived Xenograft Model Using Benign Prostatic Tissues., PMID:39222914
The concept of onychodermis containing onychofibroblasts has histological (microanatomical), immunohistochemical as well as molecular basis., PMID:39044464
Would three BMPs at low concentration be better than one at high concentration? An experimental study with rat osteoprogenitor cells., PMID:38842074
Decreased Tiam1-mediated Rac1 activation is responsible for impaired directional persistence of chondrocyte migration in microtia., PMID:38837873
Human archetypal pluripotent stem cells differentiate into trophoblast stem cells via endogenous BMP5/7 induction without transitioning through naive state., PMID:38332235
Placenta accreta spectrum disorder at single-cell resolution: a loss of boundary limits in the decidua and endothelium., PMID:38296740
Expression and Prognostic Value of m6A RNA Methylation-Related Genes in Thyroid Cancer., PMID:38033847
Identification of copy neutral loss of heterozygosity on chromosomes 1p, 1q, and 6p among nonsyndromic cleft lip and/or without cleft palate with hypodontia., PMID:38031027
Ketamine Promoted Breast Cancer Invasion and Metastasis Through Up-regulating Wnt, BMP, and EGFR Signaling., PMID:38030191
Exosomal-miR-522-3p derived from cancer-associated fibroblasts accelerates tumor metastasis and angiogenesis via repression bone morphogenetic protein 5 in colorectal cancer., PMID:37984826
In Silico Analysis: Genome-Wide Identification, Characterization and Evolutionary Adaptations of Bone Morphogenetic Protein (BMP) Gene Family in Homo sapiens., PMID:37914865
Changes in the Expression of TGF-Beta Regulatory Pathway Genes Induced by Vitamin D in Patients with Relapsing-Remitting Multiple Sclerosis., PMID:37833895
BMP5: a novel tile of the hepcidin regulatory pathway., PMID:37824161
Transcriptome analysis of osteogenic differentiation of human maxillary sinus mesenchymal stem cells using RNA-Seq., PMID:37800070
Genome-wide analysis of BMP/GDF family and DAP-seq of YY1 suggest their roles in Cynoglossus semilaevis sexual size dimorphism., PMID:37793513
Skin-type-dependent development of murine mechanosensory neurons., PMID:37607547
Therapeutic potential of pomegranate juice-derived nanovesicles in nude mouse benign prostatic hyperplasia (BPH) xenograft model., PMID:37528206
Nesfatin-1 stimulates BMP5 expression and osteoclastogenesis in rheumatoid arthritis., PMID:37481139
BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice., PMID:37478395
The dietary supplement Cyplexinol® alleviates joint pain in men and women., PMID:37457546
Targeting c-Jun Is a Potential Therapy for Luminal Breast Cancer Bone Metastasis., PMID:37310848
An in-silico Approach for Recognition of Long non-coding RNA-Associated Competing Endogenous RNA Axes in Prostate Cancer., PMID:37245085
Heterodimerization-dependent secretion of bone morphogenetic proteins in Drosophila., PMID:37054707
Changes in the Long Noncoding RNA Expression Profile in the Development of the Embryonic External Ear After BMP5 Gene Mutation., PMID:36959163
Genome-wide identification, evolution and expression analysis of bone morphogenetic protein (BMP) gene family in chinese soft-shell turtle (Pelodiscus sinensis)., PMID:36816024
BMP5 ameliorates diabetic peripheral neuropathy by augmenting mitochondrial function and inhibiting apoptosis in Schwann cells., PMID:36587524
Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension., PMID:36564027
RNA-seq identifies differentially expressed genes involved in csal1 overexpression in granulosa cells of prehierarchical follicles in Chinese Dagu hens., PMID:36442307
Identification of tumor antigens and immune subtypes in lung squamous cell carcinoma for mRNA vaccine development., PMID:36245631
Transcriptional Profiling of TGF-β Superfamily Members in Lumbar DRGs of Rats Following Sciatic Nerve Axotomy and Activin C Inhibits Neuropathic Pain., PMID:36201267
Changes in the Transcriptome-Associated Co-Expression Profile of Embryonic External Ear Development After the BMP5 Gene Mutation., PMID:36192835
Bmp5 Mutation Alters mRNA Expression During External Ear Development., PMID:36166492
Genome-wide identification, characterization and expression analysis of the BMP family associated with beak-like teeth in Oplegnathus., PMID:35923711
Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla., PMID:35853486
Bmp5 Mutation Alters miRNA Expression During Embryonic External Ear Development., PMID:35765140
Bmp5 Mutation Alters circRNA Expression During Embryonic External Ear Development., PMID:35765132
Identification of epilepsy concomitant candidate genes recognized in Saudi epileptic patients., PMID:35363364
Colon cancer diagnosis and staging classification based on machine learning and bioinformatics analysis., PMID:35339846
G9a Knockdown Suppresses Cancer Aggressiveness by Facilitating Smad Protein Phosphorylation through Increasing BMP5 Expression in Luminal A Type Breast Cancer., PMID:35054776
Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction., PMID:35013172
Characterization of mouse Bmp5 regulatory injury element in zebrafish wound models., PMID:34826632
For research use only. Not for human or drug use.
