Catalog No.
AHD48101
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of the human breast cancer cells (MCF‑7). The ED50 of this effect is 0.06-0.6 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Phe17-Gln317
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P21815
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cell-binding sialoprotein, Bone sialoprotein 2, Integrin-binding sialoprotein, BNSP, IBSP, Bone sialoprotein II, BSP II
Impact of enamel matrix proteins combined with collagen membranes on osteoblastic cell cultures., PMID:40188987
Biomarkers of the Complement System in Cancer., PMID:40152065
Hindlimb Unloading Reversibly Attenuates Osteogenic Potential of Rat Skeletal Stem and Progenitor Cells ex vivo., PMID:40101692
Sustained release of Sr and Ca from a micronanotopographic titanium surface improves osteoblast function., PMID:40097885
Osteogenesis Potential of Polymethylmethacrylate-Hydroxyapatite and Stem Cells from Human Exfoliated Deciduous Teeth as Alveolar Bone Graft: An In Silico Study., PMID:40073999
Novel Clinical Insights into the Pathogenesis of Posttraumatic Elbow Stiffness: An Expression Profile Analysis of Contracted Joint Capsule in Human., PMID:39802512
AQP3-liposome@GelMA promotes overloaded-induced degenerated disc regeneration via IBSP/ITG αVβ3/AKT pathway., PMID:39733899
Exogenous bone sialoprotein improves extraction socket healing in Ibsp knockout and wild-type mice., PMID:39722365
Therapeutic potential of farnesoid X receptor agonists for modulating inflammation and periodontal regeneration., PMID:39661179
Identifying prothrombin and bone sialoprotein as potential drug targets for idiopathic pulmonary fibrosis., PMID:39375737
Bone development by Hedgehog and Wnt signaling, Runx2, and Sp7., PMID:39352550
Regulation of Skeletal Development and Maintenance by Runx2 and Sp7., PMID:39337587
Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis., PMID:39263947
IBSP Promotes Breast Cancer Bone Metastasis and Proliferation via BMP-SMAD Signaling Pathway., PMID:39118232
In vitroosteogenesis of hMSCs on collagen membranes embedded within LEGO®-inspired 3D printed PCL constructs for mandibular bone repair., PMID:39079546
RAC1 inhibition ameliorates IBSP-induced bone metastasis in lung adenocarcinoma., PMID:39052477
Retraction note to: RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer., PMID:38994163
[Zinc finger protein-36 deficiency inhibits osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells and preosteoblasts by activating the ERK/MAPK pathway]., PMID:38708503
Two Novel Betarhabdovirins Infecting Ornamental Plants and the Peculiar Intracellular Behavior of the Cytorhabdovirus in the Liana Aristolochia gibertii., PMID:38543688
RNA-based bone histomorphometry: method and its application to explaining postpubertal bone gain in a G610C mouse model of osteogenesis imperfecta., PMID:38477760
Hsa_circ_0001480 affects osteosarcoma progression by regulating the miR-363-3p/IBSP pathway., PMID:38409882
Mef2c regulates bone mass through Sost-dependent and -independent mechanisms., PMID:38042445
High expression of integrin-binding sialoprotein (IBSP) is associated with poor prognosis of osteosarcoma., PMID:38006395
Synergic Action of Systemic Risedronate and Local Rutherpy in Peri-implantar Repair of Ovariectomized Rats: Biomechanical and Molecular Analysis., PMID:38003342
Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion., PMID:37979214
Functional defects in cementoblasts with disrupted bone sialoprotein functional domains, in vitro., PMID:37951522
Deep coverage and quantification of the bone proteome provides enhanced opportunities for new discoveries in skeletal biology and disease., PMID:37816044
RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer., PMID:37746647
Identification of an endoplasmic reticulum stress-related prognostic risk model with excellent prognostic and clinical value in oral squamous cell carcinoma., PMID:37647077
Central and peripheral tau retention modulated by an anti-tau antibody., PMID:37645819
Osteogenic induction of asiatic acid derivatives in human periodontal ligament stem cells., PMID:37644086
Protein arginine methyltransferases PRMT1, PRMT4/CARM1 and PRMT5 have distinct functions in control of osteoblast differentiation., PMID:37593409
Early induction of Hes1 by bone morphogenetic protein 9 plays a regulatory role in osteoblastic differentiation of a mesenchymal stem cell line., PMID:37565579
G-protein coupled receptor 5C (GPRC5C) is required for osteoblast differentiation and responds to EZH2 inhibition and multiple osteogenic signals., PMID:37558192
Activation of periodontal ligament cell cytodifferentiation by juxtacrine signaling from cementoblasts., PMID:37492992
The bone-protective benefits of amino-conjugated calcium in an ovariectomized (OVX) rat model., PMID:37437650
Knockout of bone sialoprotein in cementoblasts cell lines affects specific gene expression in unstimulated and mechanically stimulated conditions., PMID:37150306
Persicae Semen Promotes Bone Union in Rat Fractures by Stimulating Osteoblastogenesis through BMP-2 and Wnt Signaling., PMID:37108563
Characterization of intestinal fibrosis in cats with chronic inflammatory enteropathy., PMID:37052621
Genome-wide association study reveals that the IBSP locus affects ear size in cattle., PMID:37016135
Integrated proteome sequencing, bulk RNA sequencing and single-cell RNA sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration., PMID:37009470
Egg white improves the biological properties of an alginate-methylcellulose bioink for 3D bioprinting of volumetric bone constructs., PMID:36735961
Effect of Inactivation of Mst1 and Mst2 in the Mouse Adrenal Cortex., PMID:36405866
Bone Sialoprotein Is Critical for Alveolar Bone Healing in Mice., PMID:36377066
The First Compound Heterozygous Mutations of DMP1 Causing Rare Autosomal Recessive Hypophosphatemic Rickets Type 1., PMID:36334264
A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration., PMID:36261010
Plap-1 lineage tracing and single-cell transcriptomics reveal cellular dynamics in the periodontal ligament., PMID:36245218
The lysine methyltransferases SET and MYND domain containing 2 (Smyd2) and Enhancer of Zeste 2 (Ezh2) co-regulate osteoblast proliferation and mineralization., PMID:36191822
An Integrated Approach to Identify Intrinsically Disordered Regions in Osteopontin with its Interacting Network in Rheumatoid Arthritis., PMID:36089787
Patients with breath test positive are necessary to be identified from irritable bowel syndrome: a clinical trial based on microbiomics and rifaximin sensitivity., PMID:36070467
For research use only. Not for human or drug use.
