Catalog No.
AMC16001
Biological activity
Measured by its ability to support the adhesion of human peripheral blood acute lymphoblastic leukemia cells (HSB2). The ED50 for this effect is 0.075-0.6 µg/mL.
Expression system
Mammalian Cells
Species
Mus musculus (Mouse)
Protein length
Gln28-Asn485
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P13597
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Intercellular adhesion molecule 1, ICAM-1, MALA-2, MyD10, CD54, Icam1, Icam-1
Targeting TBK1 potentiates oncolytic virotherapy via amplifying ICAM1-mediated NK cell immunity in chemo-resistant colorectal cancer., PMID:40484646
ICAM1 778G>A (rs1799969), ADD1 1378G>T (rs4961), NPPA 553T>C (rs5065), and NOS3 894G>T (rs1799983) Variants in Infants with Gastroschisis from Western Mexico., PMID:40421935
Multiomic analysis of human kidney disease identifies a tractable inflammatory and pro-fibrotic tubular cell phenotype., PMID:40399382
IL-8 and ER-α gene polymorphisms as potential risk factors for leiomyoma., PMID:40393185
USP7-Mediated ICAM1 Facilitates Lipopolysaccharide-Induced Human Pulmonary Microvascular Endothelial Cell Injury to Accelerate Pediatric Acute Respiratory Distress Syndrome., PMID:40329406
Pharmacological inhibition of host pathways enhances macrophage killing of intracellular bacterial pathogens., PMID:40291742
Characterization of the gut microbiota in different immunological responses among PLWH., PMID:40275044
Glioblastoma cells secrete ICAM1 via FASN signaling to promote glioma-associated macrophage infiltration., PMID:40252818
Transcription factor occupancy limits DNA methylation and determines ICAM1 expression in breast cancer., PMID:40230289
Cell adhesion molecules and incident hypertension in black and white adults: the REGARDS study., PMID:40156350
Microvesicles Derived from Human Bronchial Epithelial Cells Regulate Macrophage Activation During Mycobacterium abscessus Infection., PMID:40153482
Therapeutically targeting endometrial cancer in preclinical models by ICAM1 antibody-drug conjugates., PMID:40147093
Modulation of Autophagy on Cinnamaldehyde Induced THP-1 Cell Activation., PMID:40141022
ICAM-1 Is Overexpressed by Cancers and Negatively Impacts Antibody-Based Therapies Including Antibody-Drug Conjugates., PMID:40111003
Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity., PMID:40055821
Expression, regulation, function and clinical significance of B7-H6 on neutrophils in human gastric cancer., PMID:40054066
C-X-C Motif Ligand 1 Induces Cell Migration by Upregulating ICAM-1 Expression by Activating PI3K/Akt and NF-κB Signaling Pathway in Liver Cancer., PMID:40016871
The ICAM1 p.K56M variant and risk of heart failure in chronic kidney disease: the Chronic Renal Insufficiency Cohort study., PMID:39915070
Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity., PMID:39911575
Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells., PMID:39885580
Endocan as a marker of endotheliitis in COVID-19 patients: modulation by veno-venous extracorporeal membrane oxygenation, arterial hypertension and previous treatment with renin-angiotensin-aldosterone system inhibitors., PMID:39862311
Down-regulation of platelet-derived growth factor receptor β in pericytes increases blood-brain barrier permeability and significantly enhances α-synuclein in a Parkinson's Disease 3D cell model in vitro under hyperglycemic condition., PMID:39847894
Sensing of SARS-CoV-2-infected cells by plasmacytoid dendritic cells is modulated via an interplay between CD54/ICAM-1 and CD11a/LFA-1 αL integrin., PMID:39804090
ICAM-1 K469E gene polymorphism, genotype-phenotype correlation, and retinopathy in Type 2 diabetes mellitus patients., PMID:39763306
Induction of PD-1 and CD44 in CD4+ T cells by circulatory extracellular vesicles from severe dengue patients drives endothelial damage via the NF-kB signaling pathway., PMID:39745465
ICAM-1 expression is upregulated in the umbilical vein endothelial cells in acute chorioamnionitis with foetal inflammatory response., PMID:39731491
[Effect of Dendrobii Officinalis Caulis water extract on hyperviscosity rats based on TLR4/NF-κB/ICAM-1 signaling pathway]., PMID:39701764
ICAM1+ gingival fibroblasts modulate periodontal inflammation to mitigate bone loss., PMID:39650645
Isoform-specific vs. isoform-universal drug targeting: a new targeting paradigm illustrated by new anti-ICAM-1 antibodies., PMID:39639798
Cell-to-cell adhesion via CD54 (intercellular adhesion molecule-1)-associated cell proliferation in diffuse large B-cell lymphoma cases., PMID:39603636
Graph-Based Spatial Proximity of Super-Resolved Protein-Protein Interactions Predicts Cancer Drug Responses in Single Cells., PMID:39513000
Integrative analysis of transcriptome and proteome wide association studies prioritized functional genes for obesity., PMID:39495296
Circulating IL-17F, but not IL-17A, is elevated in severe COVID-19 and leads to an ERK1/2 and p38 MAPK-dependent increase in ICAM-1 cell surface expression and neutrophil adhesion on endothelial cells., PMID:39493750
Mechanism of Xue-Jie-San treating Crohn's disease complicated by atherosclerosis: Network pharmacology, molecular docking and experimental validation., PMID:39488873
Elevated levels of peripheral and central nervous system immune markers reflect innate immune dysregulation in autism spectrum disorder., PMID:39481220
The expression of sICAM-1 influenced by Clonorchis sinensis co-infection in CHB patients., PMID:39463345
G-CSFR-induced leukocyte transendothelial migration during the inflammatory response is regulated by the ICAM1-PKCa axis: based on multiomics integration analysis., PMID:39433604
Inflammatory Status as a Predictor of Perioperative Risk in Patients Undergoing Non-Cardiac Vascular Surgery., PMID:39427978
Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population., PMID:39425874
Tumor-intrinsic role of ICAM-1 in driving metastatic progression of triple-negative breast cancer through direct interaction with EGFR., PMID:39415210
Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and E-Selectin rs1805193 Polymorphisms in African Women Living with HIV and Preeclampsia., PMID:39409189
Serum lncRNA ITGB2-AS1 and ICAM-1 as novel biomarkers for rheumatoid arthritis and osteoarthritis diagnosis., PMID:39379962
Urinary biomarkers for active Lupus Nephritis that have survived independent validation across cohorts., PMID:39370040
Targeting ICAM1 to Ameliorate Vaso-Occlusion and Inflammation in Sickle Cell Disease., PMID:39354752
Intercellular Adhesion Molecule 1 (ICAM-1): An Inflammatory Regulator with Potential Implications in Ferroptosis and Parkinson's Disease., PMID:39329738
Human rhinovirus 16 induces an ICAM-1-PKR-ATF2 axis to modulate macrophage functions., PMID:39324790
Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation., PMID:39317271
LPI-GPR55 promotes endothelial cell activation and inhibits autophagy through inducing LINC01235 expression., PMID:39316662
A one-way street recognition approach to mediate allogeneic immune cell therapies., PMID:39241752
Relation of ICAM-1 and VCAM-1 markers in COVID-19 patients in Kirkuk province., PMID:39240630
For research use only. Not for human or drug use.
