Catalog No.
AHC94101
Biological activity
Measured by its ability to cleave a colorimetric peptide substrate, N-carbobenzyloxy-Gly-ArgThioBenzyl ester (Z-GR-SBzl), in the presence of 5,5’Dithio-bis (2-nitrobenzoic acid) (DTNB). The specific activity is >5,000 pmol/min/µg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Cys26-Val262
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P12544
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
H factor, CTLA3, Cytotoxic T-lymphocyte proteinase 1, CTL tryptase, Fragmentin-1, HFSP, HF, Granzyme A, Granzyme-1, GZMA, Hanukkah factor
Association of the characteristics of brain magnetic resonance imaging with genes related to disease onset in schizophrenia patients., PMID:40158807
Identification of potential biomarkers associated with cuproptosis and immune microenvironment analysis in acute myocardial infarction: A diagnostic accuracy study., PMID:39889200
Identification of prognosis-related gene features in low-grade glioma based on ssGSEA., PMID:36591509
LCK, FOXC1 and hsa-miR-146a-5p as potential immune effector molecules associated with rheumatoid arthritis., PMID:36420648
Bioinformatics analysis of the potential biomarkers for acute respiratory distress syndrome., PMID:32856055
Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A., PMID:12590650
Involvement of protein tyrosine kinase p72syk and phosphatidylinositol 3-kinase in CD2-mediated granular exocytosis in the natural killer cell line, NK3.3., PMID:9233614
Leukophysin: an RNA helicase A-related molecule identified in cytotoxic T cell granules and vesicles., PMID:8690889
Loss of cytotoxic T lymphocyte function in Chediak-Higashi syndrome arises from a secretory defect that prevents lytic granule exocytosis., PMID:7751653
Granzyme A is an interleukin 1 beta-converting enzyme., PMID:7722467
Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway., PMID:7737276
Involvement of granule proteins in T-cell-mediated cytolysis., PMID:2215515
For research use only. Not for human or drug use.
