Catalog No.
AHC36901
Biological activity
Measured by its ability to inhibit M1 mouse myeloid leukemia cell proliferation. The ED50 for this effect is 2.5-12.5 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
IL6 [Val30-Met212] & IL6RA [Leu20-Asp358]
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P05231 & P08887
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hybridoma growth factor, BSF-2, IFN-beta-2, CDF, IL6, Interleukin-6, IL-6, B-cell stimulatory factor 2, Interferon beta-2, IFNB2, CTL differentiation factor, sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha
Investigation of the Mitigating Mechanism of Bifidobacterium longum 300 in d-Galactose-Induced Cognitive Impairment in Mice., PMID:40515700
Study on rTMS's therapeutic effect on constipation in Parkinson's disease via the brain-gut axis theory., PMID:40515608
Association of inflammatory biomarkers with morbidity and mortality risk in patients with peripheral artery disease: a systematic review and -meta-analysis., PMID:40515582
Increased Circulating Interleukin Concentrations in Type 2 Diabetes: A Systematic Review and Meta-Analysis., PMID:40515448
Uncovering metabolic pathways in human alveolar macrophages in response to lipopolysaccharide., PMID:40515396
Modulation of interleukins 38 and 1 Beta gene expression by N-(4-benzoylphenyl)-5-nitrofuran-2-carboxamide in Triton WR-1339 induced hyperlipidemic rats., PMID:40514672
Proteomic analysis of hydrogen peroxide-treated human chondrocytes shows endoplasmic reticulum stress, cytoskeleton remodeling, and altered secretome composition., PMID:40514670
Inhibitory effects of Levilactobacillus brevis IBRC-M10790 on apoptosis and inflammation induced by Clostridioides difficile culture supernatant in vitro., PMID:40514400
Prognostic Role of Serum IL-6 Levels in Bladder Cancer Patients and Hints of its Origin., PMID:40514270
Activated Factor X Inhibition Ameliorates NF-κB-IL-6‒Mediated Perivascular Inflammation and Pulmonary Hypertension., PMID:40514194
Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer., PMID:40514067
Concentrated Growth Factor Constructs Improve Wound Healing After Third Molar Surgery: A Split-Mouth Randomized Controlled Trial., PMID:40514018
Investigation of cognitive enhancements and mechanisms of kinsenoside in APP/PS1 mice through network pharmacology, in vivo experiments, and machine learning., PMID:40513940
Reduced NF-κB/NLRP3/IL-18 signaling increases the protective effect of L-glutamine against LPS-induced retinal inflammation in mice: Utilization of network pharmacology and experimental validation., PMID:40513937
Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis., PMID:40513868
Discovery of novel PDE4 degraders with in vivo anti-inflammatory efficacy., PMID:40513451
Phosphocreatine alleviates liver fibrosis in diabetic mice by targeting TGF-β/Smad and α-SMA pathways., PMID:40513426
Diet-incorporated saracatinib, a Src tyrosine kinase inhibitor, counteracts diisopropylfluorophosphate (DFP)-induced chronic neurotoxicity in the rat model., PMID:40513390
Cross-sectional association between brain-derived neurotrophic factor and intrinsic capacity in older adults: The mediating role of oxidative stress., PMID:40513379
Establishment and evaluation of a diagnostic model for severe pulmonary tuberculosis., PMID:40513133
Serum hyaluronic acid in critically ill dogs and influence of intravenous fluid therapy., PMID:40512747
Dietary plant-derived lectins induce oxidative stress, metabolic dysfunction, apoptosis and neuroinflammation in mice brain., PMID:40512724
An Optimized Probiotic Formulation Achieves Sustained Gut Microbiota Modulation and Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice., PMID:40512571
Immunoenhancing Effect of Lactobacillus Kefiranofaciens ZW18 Postbiotic On Cyclophosphamide-induced Immunosuppressed Mice., PMID:40512443
Adropin ameliorates behavioral seizures and the relevant neuroinflammation, oxidative stress, and neural damage in a rat model of pentylenetetrazole-induced seizure potentially by reducing the activation of NF-κB/IkB-α signaling pathway., PMID:40512435
Modulatory effects of Portulaca oleracea-Enriched diets against waterborne Cadmium-Induced hepatotoxicity in nile Tilapia fingerlings: involvement of oxidative stress and Inflammation-Related gene regulation., PMID:40512427
TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation., PMID:40512402
Impact of Storage on Bioactive and Toxic Compounds in Jicama (Pachyrhizus erosus) Tubers: Effects on Thyroid Cancer and Inflammatory Responses., PMID:40512265
Proteomic profiling reveals immunomodulatory role of IL-33 in ocular bacterial and fungal infections., PMID:40512033
Efficacy and Safety of External Therapies of Traditional Chinese Medicine in Patients with Knee Osteoarthritis: A Systematic Review and Network Meta-Analysis., PMID:40511477
Favorable and poor prognosis B-cell precursor acute lymphoblastic leukemia subtypes reveal distinct leukemic cell properties when interacting with mesenchymal stem cells, differentially modifying their cell stemness and leukemia chemoresistance., PMID:40511387
Expression of Vascular Endothelial Growth Factor and Interleukin-6 in bile duct healing with autologous parietal peritoneum: a non-inferiority experimental study in rabbits., PMID:40511386
Salivary Biomarkers vs. Conventional Biopsy for Oral Cancer Detection in India: A Comparative Study., PMID:40511222
Assessment of Peri-Implant Soft Tissue Reactions in Patients with Systemic Conditions: An In Vitro Cellular Analysis., PMID:40511206
Protective effect of fermented vegetable compounds against nonalcoholic fatty liver disease using metabolite profiling, integrated network pharmacology, and molecular docking approach., PMID:40510901
Role of Ocrelizumab in modulating gene and microRNA expression in multiple sclerosis., PMID:40510879
Comparison of efficacy of exosomes derived from human umbilical cord blood mesenchymal stem cells in treating mouse acute lung injury via different routes., PMID:40510682
Rhinoceromics: a multi-amplicon study with clinical markers to transferrin saturation levels in ex-situ black rhinoceros (Diceros bicornis michaeli)., PMID:40510676
SLC4A10 impedes atherosclerosis by diminishing IFN-γ/GZMB levels of CD8+ T cells via the MAPK pathway., PMID:40510365
Diagnostic utility of IL-18 plasma levels in distinguishing abdominal from non-abdominal sepsis., PMID:40510342
Outer membrane vesicles derived from probiotic Escherichia coli Nissle 1917 promote metabolic remodeling and M1 polarization of RAW264.7 macrophages., PMID:40510339
Lipopeptide Hydrogel Possesses Adjuvant-Like Properties for the Delivery of the GPC-3 Peptide-derived Antigen., PMID:40510294
ZEB2 upregulation modulates the polarization of TAMs toward the immunosuppressive state in EGFR-TKI-resistant NSCLC., PMID:40510028
Chromato-Kinetic Fingerprinting Enables Multiomic Digital Counting of Single Disease Biomarker Molecules., PMID:40509951
Association of Increased Epstein-Barr Virus Reactivation With Imbalanced Immunity and Myenteric Neuron Loss in Achalasia., PMID:40509790
Large Yellow Croaker Roe Protein Isolates/Gellan Gum Hydrogels Improve the Alleviating Effect of Curcumin on DSS-Induced Colitis., PMID:40509451
Immunoenhancement Function of the Novel Hexapeptide (LVVLGH) from Thick-Shelled Mussel (Mytilus coruscus) on Immunodeficient Mice by Activating the NF-κB/MAPK Pathway., PMID:40509394
Anxiolytic Effects of Cichorium intybus L. Oligo-Polysaccharides by Modulating Gut Microbiota, Neuronal Signaling Pathways, and Neuroinflammation in Chronic Sleep Deprivation-Stressed Mice., PMID:40509387
Design, Synthesis, and Evaluation of New 2-Arylpropanoic Acid-l-Tryptophan Derivatives for Mitigating Cisplatin-Induced Nephrotoxicity., PMID:40509291
Impact of Clove Essential Oil on the Intestinal Flora in Mice Infected with Candida albicans., PMID:40509258
For research use only. Not for human or drug use.
