Catalog No.
AHG46401
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
IL15 [Asn49-Ser162] & IL15Rα [Ile31-Asp96]
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13261 & P40933
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL15, IL-15, Interleukin-15, IL-15 receptor subunit alpha, sIL-15R-alpha, IL-15RA, CD215, sIL-15 receptor subunit alpha, Interleukin-15 receptor subunit alpha, IL-15R-alpha, sIL-15RA, IL15RA
Enhancing anti-tumor immunity of natural killer cells through targeting IL-15R signaling., PMID:40513576
Accelerating Drug Development for Neuroblastoma: Consensus Statement From the Third Neuroblastoma Drug Development Strategy Forum., PMID:40509548
Divergent Immune Pathways in Coronary Artery Disease and Aortic Stenosis: The Role of Chronic Inflammation and Senescence., PMID:40508061
Oncolytic Viruses as a Novel Therapeutic Approach for Colorectal Cancer: Mechanisms, Current Advances, and Future Directions., PMID:40507337
Origin of Hypofunctional CD103+ NK Cells in Cirrhosis-Associated Ascites., PMID:40498379
Human Papilloma Virus Type 94-Associated Flat Warts Developing Repeatedly During Tofacitinib Treatment: A Case Report and Review., PMID:40495664
Combining local cytokine delivery and systemic immunization with recombinant artLCMV boosts antitumor efficacy in several preclinical tumor models., PMID:40492380
Exploring upstream and downstream causality of inflammatory cytokines in intervertebral disc degeneration: a bidirectional, two-sample Mendelian randomization study., PMID:40488876
Grouper interleukin 15-like acts as a cytokine adjuvant in grouper iridovirus subunit vaccine., PMID:40482865
Engineering the next generation of allogeneic CAR cells: iPSCs as a scalable and editable platform., PMID:40480218
M2 Macrophage and Extracellular Matrix Genes Are Enriched in High-Activity Lichen Planopilaris., PMID:40475059
CD70 CAR-T cells empowered by TS-2021 through ex vivo transduction show potent antitumor efficacy against glioblastoma., PMID:40474210
Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV., PMID:40471871
Macrophage-derived IL-15 imprints peritoneal TRM-like CD8 T cells in cirrhosis and spontaneous bacterial peritonitis., PMID:40470117
Advances of oncolytic vaccinia viruses armed with interleukin in tumor therapy., PMID:40469178
CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells., PMID:40468083
Reduced Cish expression by siRNA knockdown in Natural Killer cells promotes anti-tumor effects against gastric cancer cell lines., PMID:40467928
Maternal inflammation during the second trimester of pregnancy with adverse birth outcomes: a prospective cohort study., PMID:40467925
Antigen-Specific Immune Responses and Microbiota Interactions in Skin: Insights into Autoimmune Skin Diseases and., PMID:40466869
Single-Nucleus and Bulk RNA Sequencing Reveals the Involvement of Natural Killer and CD8+ T Cells in the Progression of Androgenetic Alopecia., PMID:40463861
Myeloid cell IL-15 production in the brain supports Bystander CD8+ T-Cell Neuropathic Immune Responses following Virus infection., PMID:40462933
Anti-viral CD8 central memory veto cells as a new platform for CAR T cell therapy., PMID:40448965
Dysbiotic Microbiome-Metabolome Axis in Childhood Obesity and Metabolic Syndrome., PMID:40448590
Immunostimulatory effects of multiple short-hairpin RNAs enhance foot-and-mouth disease vaccine-induced humoral immunity., PMID:40441607
Natural killer cells adopt an activated and decidual-like phenotype after autologous hematopoietic stem cell transplantation in children with cancer., PMID:40437214
Transcriptomic insights into Mycobacterium orygis infection-associated pulmonary granulomas reveal multicellular immune networks and tuberculosis biomarkers in cattle., PMID:40432328
Fecal Microbiota Transplantation Using Donor Stool Obtained from Exercised Mice Suppresses Colonic Tumor Development Induced by Azoxymethane in High-Fat Diet-Induced Obese Mice., PMID:40431182
Interleukin-15Rα-Sushi-Fc Fusion Protein Co-Hitchhikes Interleukin-15 and Pheophorbide A for Cancer Photoimmunotherapy., PMID:40430906
The Immunomodulatory Effects of Apigenin and Quercetin on Cytokine Secretion by the Human Gingival Fibroblast Cell Line and Their Potential Link to Alzheimer's Disease., PMID:40430449
In Vitro Evaluation of the PMN Reaction on a Collagen-Based Purified Reconstituted Bilayer Matrix (PRBM) Using the Autologous Blood Concentrate PRF., PMID:40427065
Immunocytokines and cytokine neutralization for cancer immunotherapy., PMID:40425444
The Role of T-Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis., PMID:40411272
Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery., PMID:40406466
Engineered Mycobacterium smegmatis expressing anti-PD-L1/IL-15 immunocytokine induces and activates specific antitumor immunity., PMID:40404207
IGM-7354, an immunocytokine with IL-15 fused to an anti-PD-L1 IgM, induces NK and CD8+ T cell-mediated cytotoxicity of PD-L1 positive tumor cells., PMID:40402523
IL-15-Activated CD38+HLA-DR+CD8+ T cells induce liver injury in cirrhosis via JAK/STAT5 and PI3K/mTOR pathways., PMID:40399368
Comparison of Different Methods of Constructing a Celiac Disease Model in BALB/c Mice., PMID:40395135
Systemic secukinumab treatment in patients with ankylosing spondylitis: the relationship between systemic and tear proinflammatory cytokines and ocular surface findings-a pilot study., PMID:40394377
A diet-driven metabolic dysfunction-associated steatohepatitis (MASH) mouse model resembles the corresponding human disease., PMID:40392411
Seasonal Proteomic Variations and Biomarkers in Seasonal Allergic Rhinitis: Insights from Olink Inflammation Profiling., PMID:40386182
The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES+ Tr1-Like Cells., PMID:40375822
Hypoxia and IL-15 Cooperate to Induce Perforin Expression by CD8 T Cells and Promote Damage to the Skin in Murine Cutaneous Leishmaniasis., PMID:40373956
Genetically engineered K562 cells augment NK cell cytotoxicity against acute myeloid leukemia and reduce dependency on IL-15., PMID:40372524
Identification of Hub Genes and Pathways in Preinfusion Chimeric Antigen Receptor (CAR) T-cell Products Associated With Cytokine Release Syndrome., PMID:40370902
Trifunctional antibody-cytokine fusion protein formats for tumor-targeted combination of IL-15 with IL-7 or IL-21., PMID:40370435
Dynamic Changes in Lymphocyte Subsets and Inflammation-Immune-Related Proteins in Patients with Thyroid Papillary Carcinoma before and after Radioactive Iodine Therapy., PMID:40365939
Alterations in Immune Cell Profiles in the Liver in Diabetes Mellitus: A Systematic Review., PMID:40362271
Combination of a therapeutic cancer vaccine targeting the endogenous retroviral envelope protein ERVMER34-1 with immune-oncology agents facilitates expansion of neoepitope-specific T cells and promotes tumor control., PMID:40360436
PIM kinase control of CD8 T cell protein synthesis and cell trafficking., PMID:40359130
Relation of Cytokine Profile and Antibody Values to Post-Translational Protein Modifications in Patients with Rheumatoid Arthritis (Preliminary Data)., PMID:40353964
For research use only. Not for human or drug use.
