Catalog No.
YHC05801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe53-Pro289
Predicted molecular weight
30.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P04066
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Alpha-L-fucoside fucohydrolase 1, Alpha-L-fucosidase I, FUCA1, Alpha-L-fucosidase 1, Tissue alpha-L-fucosidase
Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma., PMID:40487392
Proteomic Analysis of Transbronchial Biopsies to Discover Novel Biomarkers for Early Identification of Chronic Lung Allograft Dysfunction., PMID:40371053
Unique N-glycosylation signatures in human iPSC derived microglia activated by Aβ oligomer and lipopolysaccharide., PMID:40210651
Early Severe Cortical Involvement and Novel FUCA1 Mutations in a Pediatric Fucosidosis Case., PMID:39865383
Fucosidosis: A Review of a Rare Disease., PMID:39796208
CTCF-activated FUCA1 functions as a tumor suppressor by promoting autophagy flux and serum α-L-fucosidase serves as a potential biomarker for prognosis in ccRCC., PMID:39342260
FUCA1: An Underexplored p53 Target Gene Linking Glycosylation and Cancer Progression., PMID:39123480
Potential predictive value of immune-related genes FUCA1 and NCKAP1L for osteosarcoma metastasis., PMID:38844271
Synthesis of fucosyllactose using α-L-fucosidases GH29 from infant gut microbial metagenome., PMID:38771321
Identification of Immune-Linked Hub Genes and Diagnostic Model Construction in Schizophrenia., PMID:37552420
Extended analysis of exome sequencing data reveals a novel homozygous deletion of exons 3 and 4 in FUCA1 gene causing fucosidosis in an Indian family., PMID:36876340
Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants., PMID:36434256
The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis., PMID:36206736
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis., PMID:35907402
Glycan degradation promotes macroautophagy., PMID:35737835
Alpha-L-Fucosidase Has Diagnostic Value in Prostate Cancer With "Gray-Zone PSA" and Inhibits Cancer Progression via Regulating Glycosylation., PMID:34881177
Altered mRNA Expression of Fucosyltransferases and Fucosidase Predicts Prognosis in Human Oral Carcinoma., PMID:34703796
Fucosidosis in Tunisian patients: mutational analysis and homology-based modeling of FUCA1 enzyme., PMID:34425818
Comparative studies on the substrate specificity and defucosylation activity of three α-l-fucosidases using synthetic fucosylated glycopeptides and glycoproteins as substrates., PMID:34126284
Identification of a novel homozygous loss-of-function mutation in FUCA1 gene causing severe fucosidosis: A case report., PMID:33906529
Clinical relevance of serum α-l-fucosidase activity in the SARS-CoV-2 infection., PMID:33826953
Macrophage M2 Co-expression Factors Correlate With the Immune Microenvironment and Predict Outcome of Renal Clear Cell Carcinoma., PMID:33692827
The Identification of a Novel Fucosidosis-Associated FUCA1 Mutation: A Case of a 5-Year-Old Polish Girl with Two Additional Rare Chromosomal Aberrations and Affected DNA Methylation Patterns., PMID:33435586
Fucosidosis-Clinical Manifestation, Long-Term Outcomes, and Genetic Profile-Review and Case Series., PMID:33266441
Evaluation of p53 and Its Target Gene Expression as Potential Biomarkers of Cholangiocarcinoma in Thai Patients., PMID:32212809
Fucosidosis with Pathogenic Variant in FUCA1 Gene., PMID:32125660
Identification of Five Novel Mutations Causing Rare Lysosomal Storage Diseases., PMID:31603145
Plasma α-L-fucosidase-1 in patients with Sjögren's syndrome and other rheumatic disorders., PMID:31419081
Equine chorionic gonadotropin increases estradiol levels in the bovine oviduct and drives the transcription of genes related to fertilization in superstimulated cows., PMID:31353672
A Novel Homozygous Mutation in the FUCA1 Gene Highlighting Fucosidosis as a Cause of Dystonia: Case Report and Literature Review., PMID:31064022
Alpha-L-fucosidase-1 is a diagnostic marker that distinguishes mucoepidermoid carcinoma from squamous cell carcinoma., PMID:30729618
Can the antral follicular count modulate the gene expression of bovine oviducts in Aberdeen Angus and Nelore heifers?, PMID:30157205
Reduced expression of α-L-Fucosidase-1 (FUCA-1) predicts recurrence and shorter cancer specific survival in luminal B LN+ breast cancer patients., PMID:29632639
A novel homozygous frameshift mutation in the FUCA1 gene causes both severe and mild fucosidosis., PMID:29588375
Transcriptomic analysis of FUCA1 knock-down in keratinocytes reveals new insights into the pathogenesis of fucosidosis skin lesions., PMID:29518279
Longitudinal Transcriptional Response of Glycosylation-Related Genes, Regulators, and Targets in Cancer Cell Lines Treated With 11 Antitumor Agents., PMID:29276373
Identification and analysis of seven effector protein families with different adaptive and evolutionary histories in plant-associated members of the Xanthomonadaceae., PMID:29170530
High Resolution Proteomic Analysis of the Cervical Cancer Cell Lines Secretome Documents Deregulation of Multiple Proteases., PMID:29109100
Proteomics analysis of bladder cancer invasion: Targeting EIF3D for therapeutic intervention., PMID:29050215
FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status., PMID:28440416
Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer., PMID:28404918
Novel mutations in the FUCA1 gene that cause fucosidosis., PMID:27706744
A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease., PMID:27491075
p53 directly regulates the glycosidase FUCA1 to promote chemotherapy-induced cell death., PMID:27315169
The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease., PMID:27154971
Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells., PMID:26998741
MRI and MRS findings in fucosidosis; a rare lysosomal storage disease., PMID:26515723
Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface., PMID:26204487
In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases., PMID:29142681
For research use only. Not for human or drug use.
