Catalog No.
AHA96901
Biological activity
Measured by its binding ability in a functional ELISA. When human IgM is immobilized at 2 μg/mL, 100 μL/well, recombinant human FCMR/FAIM3 (Cat #: AHA96901) binds with an ED50 of 0.4-2 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg18-Gly251
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
O60667
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Regulator of Fas-induced apoptosis Toso, FCMR, Fas apoptotic inhibitory molecule 3, IgM Fc fragment receptor, FAIM3, TOSO
B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic Mycobacterium tuberculosis lung infection in Diversity Outbred mice., PMID:38899881
Functions of IgM fc receptor (FcµR) related to autoimmunity., PMID:38465789
Enhanced Mott cell formation linked with IgM Fc receptor (FcμR) deficiency., PMID:37098762
A biomechanical-based approach to scale blast-induced molecular changes in the brain., PMID:36028539
Prokineticins as a Prognostic Biomarker for Low-Grade Gliomas: A Study Based on The Cancer Genome Atlas Data., PMID:35845958
Soluble Fc Receptor for IgM in Sera From Subsets of Patients With Chronic Lymphocytic Leukemia as Determined by a New Mouse Monoclonal Antibody., PMID:35784336
An Unexpected Role for Cell Density Rather than IgM in Cell-Surface Display of the Fc Receptor for IgM on Human Lymphocytes., PMID:35042773
Essential role of TOSO/FAIM3 in intestinal IgM reverse transcytosis., PMID:34788614
Loss of synergistic transcriptional feedback loops drives diverse B-cell cancers., PMID:34461601
Identification of the Fc-alpha/mu receptor in Xenopus provides insight into the emergence of the poly-Ig receptor (pIgR) and mucosal Ig transport., PMID:34411303
Soluble mannose receptor induces proinflammatory macrophage activation and metaflammation., PMID:34326259
Differences between Human and Mouse IgM Fc Receptor (FcµR)., PMID:34209905
TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia., PMID:32784334
TGIF2 promotes cervical cancer metastasis by negatively regulating FCMR., PMID:32572908
Low FCMR mRNA expression in leukocytes of patients with Kawasaki disease six months after disease onset., PMID:32073687
Identification of increased expression of activating Fc receptors and novel findings regarding distinct IgE and IgM receptors in Kawasaki disease., PMID:31816620
Fcmr regulates mononuclear phagocyte control of anti-tumor immunity., PMID:31213601
Functional Roles of the IgM Fc Receptor in the Immune System., PMID:31130948
Fcμ receptor as a Costimulatory Molecule for T Cells., PMID:30840890
Immunoglobulin-like Domain of HsFcμR as a Capture Molecule for Detection of Crimean-Congo Hemorrhagic Fever Virus- and Zika Virus-Specific IgM Antibodies., PMID:30709812
Imaging glial activation in patients with post-treatment Lyme disease symptoms: a pilot study using [11C]DPA-713 PET., PMID:30567544
Surface receptor Toso controls B cell-mediated regulation of T cell immunity., PMID:29461978
Effects of Histone Deacetylase Inhibitor Panobinostat (LBH589) on Bone Marrow Mononuclear Cells of Relapsed or Refractory Multiple Myeloma Patients and Its Mechanisms., PMID:29080899
sIgM-FcμR Interactions Regulate Early B Cell Activation and Plasma Cell Development after Influenza Virus Infection., PMID:28747342
Clinical effectiveness and cost-effectiveness results from the randomised, Phase IIB trial in previously untreated patients with chronic lymphocytic leukaemia to compare fludarabine, cyclophosphamide and rituximab with fludarabine, cyclophosphamide, mitoxantrone and low-dose rituximab: the Attenuated dose Rituximab with ChemoTherapy In Chronic lymphocytic leukaemia (ARCTIC) trial., PMID:28628003
Glycan-independent binding and internalization of human IgM to FCMR, its cognate cellular receptor., PMID:28230186
Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL., PMID:28216660
Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity., PMID:26607794
The application of anti-Toso antibody enhances CD8(+) T cell responses in experimental malaria vaccination and disease., PMID:26597034
Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR., PMID:25888699
Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection., PMID:25257173
Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice., PMID:24994818
Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells., PMID:24398517
Complement-activating IgM enhances the humoral but not the T cell immune response in mice., PMID:24250831
FcμR (Toso/Faim3) is not an inhibitor of Fas-mediated cell death in mouse T and B cells., PMID:23520334
Involvement of Toso in activation of monocytes, macrophages, and granulocytes., PMID:23359703
Mouse IgM Fc receptor, FCMR, promotes B cell development and modulates antigen-driven immune responses., PMID:23267023
Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (FcμR)., PMID:22984178
Toso, a functional IgM receptor, is regulated by IL-2 in T and NK cells., PMID:22675200
TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation., PMID:21908732
[Expression and prognostic significance of TOSO in CD19+ B cells from Chinese CLL patients]., PMID:21756805
Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination., PMID:21613257
Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients., PMID:21264533
A randomized phase II trial of fludarabine, cyclophosphamide and mitoxantrone (FCM) with or without rituximab in previously treated chronic lymphocytic leukaemia., PMID:21231927
TOSO is overexpressed and correlated with disease progression in Chinese patients with chronic lymphocytic leukemia., PMID:21133733
Identification of TOSO/FAIM3 as an Fc receptor for IgM., PMID:20042454
Identity of the elusive IgM Fc receptor (FcmuR) in humans., PMID:19858324
CD25 blockade protects T cells from activation-induced cell death (AICD) via maintenance of TOSO expression., PMID:19703010
Fludarabine, cyclophosphamide, mitoxantrone plus rituximab (FCM-R) in frontline CLL <70 Years., PMID:19646755
Overexpression of the Fas-inhibitory molecule TOSO: a novel antiapoptotic factor in chronic lymphocytic leukemia., PMID:19347734
For research use only. Not for human or drug use.
