Catalog No.
AHA93301
Biological activity
Measured by its ability to transfer sulfate from PAPS to PSGL-1 peptide (Gln-Ala-Thr-Glu-Tyr-Glu-Tyr-Leu-Asp-Tyr-Asp-PheLeu-Pro-GluThr). The specific activity is >5 pmol/min/μg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln26-Glu370
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
O60507
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein-tyrosine sulfotransferase 1, Tyrosylprotein sulfotransferase 1, TPST-1, TPST1
Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma., PMID:39893495
Functional Characterization of Plant Peptide-Containing Sulfated Tyrosine (PSY) Family in Wheat (Triticum aestivum L.)., PMID:39684375
A modified model of PANoptosisto identify prognosis and immunotherapy response in bladder cancer., PMID:39368544
Identification, isoform classification, ligand binding, and database construction of the protein-tyrosine sulfotransferase family in metazoans., PMID:39348753
Evaluation of circulating plasma proteins in prostate cancer using mendelian randomization., PMID:39287922
Characteristic changes in the mRNA expression profile of plasma exosomes from patients with MPO-ANCA-associated vasculitis and its possible correlations with pathogenesis., PMID:39287711
Validation of candidate protein biomarkers previously identified by genetic instruments for prostate cancer risk: A prospective cohort analysis of directly measured protein levels in the ARIC study., PMID:39148211
Bioinformatics analysis to screen the key genes in pediatric Chronic Active Epstein-Barr Virus Infection., PMID:37715397
ADY tripeptide is a minimum sequence for Tyrosylprotein sulfotransferases 1 and 2 substrate recognition., PMID:37490834
Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis., PMID:37424015
Identification of immune-related genes in diagnosing atherosclerosis with rheumatoid arthritis through bioinformatics analysis and machine learning., PMID:36969166
Comprehensive FGFR3 alteration-related transcriptomic characterization is involved in immune infiltration and correlated with prognosis and immunotherapy response of bladder cancer., PMID:35958598
Tyrosine sulphation of CXCR4 induces the migration of fibroblast in OSF., PMID:35150031
The catalytic reaction mechanism of tyrosylprotein sulfotransferase-1., PMID:34647946
Identifying critical genes associated with aneurysmal subarachnoid hemorrhage by weighted gene co-expression network analysis., PMID:34542421
Tyrosylprotein sulfotransferase-dependent and -independent regulation of root development and signaling by PSK LRR receptor kinases in Arabidopsis., PMID:34028532
Root meristem growth factor RGF, a sulfated peptide hormone in plants., PMID:33901628
Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors., PMID:35530783
A co-expression network for differentially expressed genes in bladder cancer and a risk score model for predicting survival., PMID:31333338
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors., PMID:29934490
Structural basis for the broad substrate specificity of the human tyrosylprotein sulfotransferase-1., PMID:28821720
Tyrosylprotein sulfotransferase 1 expression is negatively correlated with c‑Met and lymph node metastasis in human lung cancer., PMID:26238632
Heterodimers of tyrosylprotein sulfotransferases suggest existence of a higher organization level of transferases in the membrane of the trans-Golgi apparatus., PMID:25660941
Phytosulfokine peptide signaling controls pollen tube growth and funicular pollen tube guidance in Arabidopsis thaliana., PMID:25174442
Genetic variation in microRNA-binding site and prognosis of patients with colorectal cancer., PMID:25079514
Salivary gland hypofunction in tyrosylprotein sulfotransferase-2 knockout mice is due to primary hypothyroidism., PMID:23951251
Tyrosylprotein sulfotransferase-1 and tyrosine sulfation of chemokine receptor 4 are induced by Epstein-Barr virus encoded latent membrane protein 1 and associated with the metastatic potential of human nasopharyngeal carcinoma., PMID:23472069
Phytosulfokine control of growth occurs in the epidermis, is likely to be non-cell autonomous and is dependent on brassinosteroids., PMID:23083315
The tyrosine-sulfated peptide receptors PSKR1 and PSY1R modify the immunity of Arabidopsis to biotrophic and necrotrophic pathogens in an antagonistic manner., PMID:23062058
Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2., PMID:22745813
Phytosulfokine-α controls hypocotyl length and cell expansion in Arabidopsis thaliana through phytosulfokine receptor 1., PMID:21698171
Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands., PMID:21665277
Tyrosine sulfation of native mouse Psgl-1 is required for optimal leukocyte rolling on P-selectin in vivo., PMID:21633705
Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm., PMID:21339297
Lack of protein-tyrosine sulfation disrupts photoreceptor outer segment morphogenesis, retinal function and retinal anatomy., PMID:21039965
Tyrosylprotein sulfotransferase regulates collagen secretion in Caenorhabditis elegans., PMID:20229090
A versatile polyacrylamide gel electrophoresis based sulfotransferase assay., PMID:20146816
Wnt11/5a complex formation caused by tyrosine sulfation increases canonical signaling activity., PMID:19747829
Lack of tyrosylprotein sulfotransferase activity in hematopoietic cells drastically attenuates atherosclerosis in Ldlr-/- mice., PMID:19679829
Tyrosine sulfation: an increasingly recognised post-translational modification of secreted proteins., PMID:19658209
Protein tyrosine-O-sulfation in the retina., PMID:19523945
Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivo., PMID:19047058
Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases., PMID:18834145
Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2., PMID:18672380
Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency., PMID:18243191
[Regulation of tyrosylprotein sulfotransferases activity by sulfotyrosine]., PMID:17536277
Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients., PMID:17082220
Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody., PMID:17046811
Differential enzymatic characteristics and tissue-specific expression of human TPST-1 and TPST-2., PMID:17028309
Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment., PMID:16859706
For research use only. Not for human or drug use.
