Catalog No.
AHA58501
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of Neuro‑2A mouse neuroblastoma cells. recombinant human FLRT2 (Cat #: AHA58501) immobilized at 5 μg/mL, 100 μL/well, will mediate >50% Neuro‑2A cell adhesion.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Cys36-Ser539
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
O43155
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FLRT2, Fibronectin-like domain-containing leucine-rich transmembrane protein 2, Leucine-rich repeat transmembrane protein FLRT2, KIAA0405
Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis., PMID:40405979
Finding Potential Drug Targets for Pre-Eclampsia Using Mendelian Randomisation and Colocalisation Analysis., PMID:40028697
Regulatory T cells crosstalk with tumor cells and endothelium through lymphotoxin signaling., PMID:39622857
Vascular FLRT2 regulates venous-mediated angiogenic expansion and CNS barriergenesis., PMID:39609404
Genes Related to Motility in an Ionizing Radiation and Estrogen Breast Cancer Model., PMID:39596804
The NEDD4/FLRT2 axis regulates NSCLC cell stemness., PMID:39444619
Serum Biomarker Signatures of Choroid Plexus Volume Changes in Multiple Sclerosis., PMID:39062538
Identification of a subpopulation of highly adherent endothelial cells for seeding synthetic vascular grafts., PMID:38972570
FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway., PMID:38587072
FLRT2 mediates chondrogenesis of nasal septal cartilage and mandibular condyle cartilage., PMID:38584835
The value of a three-microRNA panel in serum for prostate cancer screening., PMID:37960876
Rejection of inappropriate synaptic partners in mouse retina mediated by transcellular FLRT2-UNC5 signaling., PMID:37557174
FLRT2 suppresses bladder cancer progression through inducing ferroptosis., PMID:37480224
Loss of flrt2 gene leads to microphthalmia in zebrafish., PMID:37259881
Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome., PMID:37212950
LncRNA ZFAS1 protects chondrocytes from IL-1β-induced apoptosis and extracellular matrix degradation via regulating miR-7-5p/FLRT2 axis., PMID:37098630
Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis., PMID:37090697
Sex difference on fibroblast growth factors (FGFs) expression in skin and wound of streptozotocin(STZ)-induced type 1 diabetic mice., PMID:36536184
Respiratory immune status and microbiome in recovered COVID-19 patients revealed by metatranscriptomic analyses., PMID:36483456
In the developing cerebral cortex: axonogenesis, synapse formation, and synaptic plasticity are regulated by SATB2 target genes., PMID:36028553
Prospective Proteomic Study Identifies Potential Circulating Protein Biomarkers for Colorectal Cancer Risk., PMID:35805033
Identification of Genomic Regions and Candidate Genes for Litter Traits in French Large White Pigs Using Genome-Wide Association Studies., PMID:35739920
The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs., PMID:35700726
Tumor-specific interendothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness., PMID:35104247
Expression of FLRT2 in Postnatal Central Nervous System Development and After Spinal Cord Injury., PMID:34744626
LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion., PMID:34581723
FLRT2 and FLRT3 Cooperate in Maintaining the Tangential Migratory Streams of Cortical Interneurons during Development., PMID:34301831
Novel immune-related signature for risk stratification and prognosis in prostatic adenocarcinoma., PMID:34252262
Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks., PMID:34083484
Osteoclast Multinucleation: Review of Current Literature., PMID:32784443
Effects of fasting on the expression pattern of FGFs in different skeletal muscle fibre types and sexes in mice., PMID:32156311
Flrt2 is involved in fine-tuning of osteoclast multinucleation., PMID:31383250
Whole Genome Messenger RNA Profiling Identifies a Novel Signature to Predict Gastric Cancer Survival., PMID:30702489
A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity., PMID:29983322
Super Secondary Structure Consisting of a Polyproline II Helix and a β-Turn in Leucine Rich Repeats in Bacterial Type III Secretion System Effectors., PMID:29651716
Enhanced synaptic plasticity and spatial memory in female but not male FLRT2-haplodeficient mice., PMID:29487336
Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling., PMID:28576770
Epigenetically regulated Fibronectin leucine rich transmembrane protein 2 (FLRT2) shows tumor suppressor activity in breast cancer cells., PMID:28325946
Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice., PMID:27956228
Stripe Assay to Study the Attractive or Repulsive Activity of a Protein Substrate Using Dissociated Hippocampal Neurons., PMID:27403728
Super-complexes of adhesion GPCRs and neural guidance receptors., PMID:27091502
Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells., PMID:27023521
Methylation profiling identified novel differentially methylated markers including OPCML and FLRT2 in prostate cancer., PMID:26890304
An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina., PMID:26633812
Structural basis of latrophilin-FLRT interaction., PMID:25728924
FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development., PMID:25374360
Gene expression profiles in peripheral blood mononuclear cells of Asian obstructive sleep apnea patients., PMID:24732660
FLRT2 interacts with fibronectin in the ATDC5 chondroprogenitor cells., PMID:24585683
Genome-wide association study of age at menarche in African-American women., PMID:23599027
An innovative method to identify autoantigens expressed on the endothelial cell surface: serological identification system for autoantigens using a retroviral vector and flow cytometry (SARF)., PMID:23401699
For research use only. Not for human or drug use.
