Catalog No.
AHK97801
Biological activity
Measured by its binding ability in a functional ELISA. Immoblized rhBMP-4 at 1 µg/mL (100 µL/well) can bind human RGMB (Cat #: AHK97801) with a linear range of 10-500 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly87-Asp209 & Pro210-Ser452
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
AAH67736
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, Rgmb, Repulsive guidance molecule B
Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish., PMID:40305763
RGMb drives macrophage infiltration to aggravate kidney disease., PMID:40080642
Interferon-γ-stimulated antigen-presenting cancer-associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer., PMID:40056907
Mendelian randomization analysis to identify potential drug targets for osteoarthritis., PMID:39932908
Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings., PMID:39588913
Repulsive guidance molecules b (RGMb): molecular mechanism, function and role in diseases., PMID:39375839
Proteomics of left ventricular structure in the Multi-Ethnic Study of Atherosclerosis., PMID:39263947
PD-L2 mediates tobacco smoking-induced recruitment of regulatory T cells via the RGMB/NFκB/CCL20 cascade., PMID:39042313
Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analyses., PMID:38614964
LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer., PMID:38574881
Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells., PMID:38425400
The B7:CD28 family and friends: Unraveling coinhibitory interactions., PMID:38354702
Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease., PMID:38049831
Regulatory role of RGMb in lung injury promoted by the combination of carbon ion irradiation and anti-PD-1 antibody through Erk1/2 and p38 MAPK pathways., PMID:38042034
RGMb expression in goat uterine tissues: possible role of RGMb in the proliferation and apoptosis of endometrial epithelial cells., PMID:37967584
RGMb impacts partial epithelial-mesenchymal transition and BMP2-Induced ID mRNA expression independent of PD-L2 in nonsmall cell lung cancer cells., PMID:37434531
Microbiota-associated immunotherapy resistance caused by deficient PD-L2 - RGMb signaling., PMID:37396957
Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance., PMID:37138075
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion., PMID:36869048
Immunoregulatory effects of RGMb in gut inflammation., PMID:36420263
RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival., PMID:36153321
Human sensory neurons modulate melanocytes through secretion of RGMB., PMID:36130522
An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy., PMID:35924382
Tissue and circulating PD-L2: moving from health and immune-mediated diseases to head and neck oncology., PMID:35569724
RNA sequence analysis identified bone morphogenetic protein-2 (BMP2) as a biomarker underlying form deprivation myopia., PMID:35494490
Long non-coding RNA RGMB-AS1 represses nasopharyngeal carcinoma progression via binding to forkhead box A1., PMID:35184697
Circular RNA_0001073 (circ_0001073) Suppresses The Progression of Non-Small Cell Lung Cancer via miR-582-3p/RGMB Axis., PMID:34939762
Curcumin mediates repulsive guidance molecule B (RGMb) in the treatment mechanism of renal fibrosis induced by unilateral ureteral obstruction., PMID:34751624
LncRNA RGMB-AS1 up-regulates ANKRD1 Through Competitively Sponging miR-3614-5p to Promote OSA Cell Proliferation and Invasion., PMID:34583851
LncRNA RGMB-AS1 facilitates pancreatic cancer cell proliferation and migration but inhibits cell apoptosis via miR-574-3p/PIM3 axis., PMID:34468207
Emerging concepts in PD-1 checkpoint biology., PMID:34006473
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling., PMID:33740419
Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex., PMID:32576689
Emerging evidence for cell-autonomous axon guidance., PMID:32279322
RGMB-AS1/miR-22-3p/NFIB axis contributes to the progression of gastric cancer., PMID:32064882
Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease., PMID:31694701
Extracellular phosphorylation drives the formation of neuronal circuitry., PMID:31451763
LncRNA RGMB-AS1 promotes laryngeal squamous cell carcinoma cells progression via sponging miR-22/NLRP3 axis., PMID:31351424
PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer., PMID:31159869
RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4., PMID:31061392
Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways., PMID:30886151
Variation in the repulsive guidance molecule family in human populations., PMID:30746893
Blockade of RGMb inhibits allergen-induced airways disease., PMID:30703386
Identification of Potential Biomarkers Involved in Gastric Cancer Through Integrated Analysis of Non-Coding RNA Associated Competing Endogenous RNAs Network., PMID:30336538
Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells., PMID:30266680
Necroptosis in Acute Kidney Injury., PMID:29852497
LncRNA RGMB-AS1 is activated by E2F1 and promotes cell proliferation and invasion in papillary thyroid carcinoma., PMID:29687852
RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism., PMID:29382757
The clinical significance and biological function of lncRNA RGMB-AS1 in hepatocellular carcinoma., PMID:29288973
Expression of RGMb in brain tissue of MCAO rats and its relationship with axonal regeneration., PMID:29246630
For research use only. Not for human or drug use.
