Catalog No.
VMK16001
Species reactivity
Mouse, Rat
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
C-type lectin domain family 5 member A, C-type lectin superfamily member 5, Myeloid DAP12-associating lectin 1 (MDL-1), CLEC5A, CLECSF5, MDL1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9R007
Applications
ELISA, FuncS
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0289
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor., PMID:38849345
Current and emerging biomarkers for ulcerative colitis., PMID:37933807
CLEC5A expression can be triggered by spike glycoprotein and may be a potential target for COVID-19 therapy., PMID:36571274
Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss., PMID:35835390
CLEC5a-directed bispecific antibody for effective cellular phagocytosis., PMID:35293277
Activation of the Innate Immune Checkpoint CLEC5A on Myeloid Cells in the Absence of Danger Signals Modulates Macrophages' Function but Does Not Trigger the Adaptive T Cell Immune Response., PMID:35252461
Activation of an Effective Immune Response after Yellow Fever Vaccination Is Associated with the Genetic Background and Early Response of IFN-γ and CLEC5A., PMID:33445752
CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo., PMID:27795434
CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality., PMID:22536153
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice., PMID:22005300
Do MDL-1⁺ cells play a broad role in acute inflammation?, PMID:22005298
Targeting C-type lectin for the treatment of flavivirus infections., PMID:21618140
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis., PMID:20212065
CLEC5A is critical for dengue-virus-induced lethal disease., PMID:18496526
For research use only. Not for human or drug use.
