Catalog No.
EHG91201
Expression system
Mammalian cells
Species
Homo sapiens (Human)
Protein length
Met1-Gln1912
Predicted molecular weight
218.71kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14839
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in 20 mM Tris-HCl pH 8.0, 100 mM NaCl,1mM EDTA, 4%trehalose,1% mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CHD4, Mi2-beta, Chromodomain-helicase-DNA-binding protein 4, CHD-4, Mi-2 autoantigen 218 kDa protein, ATP-dependent helicase CHD4
Generation and characterization of a mouse model of conditional Chd4 knockout in the endometrial epithelium., PMID:40501592
Intrinsically Disordered Regions Define Unique Protein Interaction Networks in CHD Family Remodelers., PMID:40372282
Selective identification of epigenetic regulators at methylated genomic sites by SelectID., PMID:40251151
SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity., PMID:40158221
Serum-Based Proteomic Approach to Identify Clinical Biomarkers of Radiation Exposure., PMID:40149344
DUBR non-coding RNA regulates gene expression by affecting AP-1 enhancer accessibility., PMID:40117000
Chromatin Remodulator CHD4: A Potential Target for Cancer Interception., PMID:40004553
Chromatin remodeler CHD4 establishes chromatin states required for ovarian reserve formation, maintenance and male germ cell survival., PMID:39907108
TP53 Mutations and PD-L1 Amplification in Vulvar Adenocarcinoma of the Intestinal Type: Insights From Whole Exome Sequencing of 2 Cases., PMID:39868745
Discovery of a DNA methylation profile in individuals with Sifrim-Hitz-Weiss syndrome., PMID:39824190
The chromatin remodeler ADNP regulates neurodevelopmental disorder risk genes and neocortical neurogenesis., PMID:39808658
Identification of modulators of the ALT pathway through a native FISH-based optical screen., PMID:39729394
Identification of Potential Genes in Rheumatoid Arthritis-Associated Interstitial Lung Disease Using RNA-seq and In Vitro Analyses., PMID:39723749
CHD4 Interacts With TBX5 to Maintain the Gene Regulatory Network of Postnatal Atrial Cardiomyocytes., PMID:39677667
The Roles of H3K9me3 Writers, Readers, and Erasers in Cancer Immunotherapy., PMID:39519018
A LANA peptide inhibits tumor growth by inducing CHD4 protein cleavage and triggers cell death., PMID:39488208
Circular RNA circWBSCR22 facilitates colorectal cancer metastasis by enhancing CHD4's protein stability., PMID:39486700
NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4., PMID:39362776
How does CHD4 slide nucleosomes?, PMID:39221830
CHD4 R975H mutant activates tumorigenic pathways and promotes stemness and M2-like macrophage polarization in endometrial cancer., PMID:39127769
TERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer., PMID:39097722
ChAHP2 and ChAHP control diverse retrotransposons by complementary activities., PMID:38960717
Human Genetics of Atrial Septal Defect., PMID:38884726
Endothelial Chromatin-Remodeling Enzymes Regulate the Production of Critical ECM Components During Murine Lung Development., PMID:38868942
Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization., PMID:38867170
FOXM1 and CHD4 expression is associated with chemoresistance in hepatoblastoma., PMID:38761648
The immune cells have complex causal regulation effects on cancers., PMID:38710118
Identification of key eRNAs for intervertebral disc degeneration by integrated multinomial bioinformatics analysis., PMID:38704519
lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation., PMID:38649186
Transposable elements regulate thymus development and function., PMID:38635416
CHD4 and SMYD1 repress common transcriptional programs in the developing heart., PMID:38619323
CHD4 acts as a prognostic factor and drives radioresistance in HPV negative HNSCC., PMID:38594331
Clinicopathological Significance of Nucleosome Remodeling and Deacetylase Complex Expression in Endometrial Carcinoma., PMID:38538000
Gene amplification of chromatin remodeling factor SMARCC2 and low protein expression of ACTL6A are unfavorable factors in ovarian high‑grade serous carcinoma., PMID:38516682
Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart., PMID:38419169
Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in developing cochlea., PMID:38352369
Identification and characterization of CHD4-associated eRNA as a novel modulator of fetal hemoglobin levels in β-thalassemia., PMID:38325179
CHD4-induced up-regulation of ERα activity contributes to breast cancer progression., PMID:38292202
Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4., PMID:38281186
Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition., PMID:38268032
Kaposi's sarcoma-associated herpesvirus terminal repeat regulates inducible lytic gene promoters., PMID:38240593
Effects of Purine Metabolism-Related LINC01671 on Tumor Heterogeneity in Kidney Renal Clear Cell Carcinoma., PMID:38179759
Galectin-7 Induction by EHMT2 Inhibition Enhances Immunity in Microsatellite Stability Colorectal Cancer., PMID:38065340
Evidence of a synthetic lethality interaction between SETDB1 histone methyltransferase and CHD4 chromatin remodeling protein in a triple negative breast cancer cell line., PMID:37970920
The Chromatin Remodeler CHD4 Sustains Ewing Sarcoma Cell Survival by Controlling Global Chromatin Architecture., PMID:37963210
β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4., PMID:37883227
Chromatin gatekeeper and modifier CHD proteins in development, and in autism and other neurological disorders., PMID:37851134
Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation., PMID:37813864
Divergent phenotypes in constitutive versus conditional mutant mouse models of Sifrim-Hitz-Weiss syndrome., PMID:37738575
BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells., PMID:37737560
For research use only. Not for human or drug use.
