Catalog No.
PHA55801
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human SOCS1 (Ser60-Ile211).
Target
SOCS-1, SSI-1, JAB, JAK-binding protein, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling 1, Tec-interacting protein 3, TIP-3, SSI1, SOCS1, TIP3
Purification
Antigen affinity purification.
Accession
O15524
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
IL-4 mediated TAP2 downregulation is a dominant and reversible mechanism of immune evasion and immunotherapy resistance in non-small cell lung cancer., PMID:40091029
Interim PET after 4 cycles predicts outcome in histomolecularly confirmed primary mediastinal B-cell lymphoma., PMID:40030008
Borrelia burgdorferi sensu lato inhibits CIITA transcription through pSTAT3 activation and enhanced SOCS1 and SOCS3 expression leading to limited IFN-γ production., PMID:39879745
Integrative genomic analysis of DLBCL identifies immune environments associated with bispecific antibody response., PMID:39869833
Efficacy and Safety of Polatuzumab Vedotin Plus Rituximab, Cyclophosphamide, Doxorubicin and Prednisone for Previously Untreated Diffuse Large B-Cell Lymphoma: A Real-World, Multi-Center, Retrospective Cohort Study., PMID:39641321
Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling., PMID:39605016
Single-cell transcriptome analysis of the early immune response in the lymph nodes of Borrelia burgdorferi-infected mice., PMID:39306236
Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes., PMID:39046281
Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus., PMID:39028869
Case Report: Common variable immunodeficiency phenotype and granulomatous-lymphocytic interstitial lung disease with a novel SOCS1 variant., PMID:39005503
Targeting Nuclear Receptor Coactivator SRC-1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD-L1., PMID:38953362
Transcriptome Analysis Reveals the Induction of Apoptosis-Related Genes by a Monoclonal Antibody against a New Epitope of CD99 on T-Acute Lymphoblastic Leukemia., PMID:38804310
Interleukin-4 from curcumin-activated OECs emerges as a central modulator for increasing M2 polarization of microglia/macrophage in OEC anti-inflammatory activity for functional repair of spinal cord injury., PMID:38448976
Differential anti-viral response to respiratory syncytial virus A in preterm and term infants., PMID:38447274
Downregulation of lncRNA CDKN2B-AS1 attenuates inflammatory response in mice with allergic rhinitis by regulating miR-98-5p/SOCS1 axis., PMID:38436805
Deep resolution of clinical, cellular and transcriptomic inflammatory markers of psoriasis over 52 weeks of interleukin-17A inhibition by secukinumab., PMID:38240024
IL4Rα and IL17A Blockade Rescue Autoinflammation in SOCS1 Haploinsufficiency., PMID:38157076
The Promotion of Humoral Immune Responses in Humans via SOCS1-Mediated Th2-Bias Following SARS-CoV-2 Vaccination., PMID:38006062
Identification of Diagnosis and Typological Characteristics Associated with Ferroptosis for Ulcerative Colitis via Bioinformatics and Machine Learning., PMID:37957905
Aberrant expression of suppressor of cytokine signaling (SOCS) molecules contributes to the development of allergic diseases., PMID:37641429
Increased SOCS1 and SOCS3 expression in papillary thyroid carcinoma and its association with prognosis., PMID:37522675
Anti-G protein antibodies targeting the RSV G protein CX3C chemokine region improve the interferon response., PMID:36938145
Copy Number Alteration and Mutational Profile of High-Grade B-Cell Lymphoma with MYC and BCL2 and/or BCL6 Rearrangements, Diffuse Large B-Cell Lymphoma with MYC-Rearrangement, and Diffuse Large B-Cell Lymphoma with MYC-Cluster Amplification., PMID:36497332
[Effect of HDAC Inhibitor Chidamide on PD-L1 Expression in Peripheral T-Cell Lymphoma]., PMID:36476897
Etanercept alleviates psoriasis by reducing the Th17/Treg ratio and promoting M2 polarization of macrophages., PMID:36444619
Phosphatase control of cytokine-mediated overproduction of galactose-deficient IgA1, the main autoantigen in IgA nephropathy., PMID:35987175
Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli., PMID:35413868
In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4+ TH1 cell response., PMID:34860579
Combination of two monoclonal antibodies with SOCS1 N- and C-terminal binding sites to address SOCS1 status in B cells and B-cell lymphoma., PMID:34854137
B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction., PMID:34671026
Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer's disease., PMID:34611142
Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas: A Series of 22 Cases Expanding the Spectrum of Transdifferentiation., PMID:34265801
Type I T cells sensitize treatment refractory tumors to chemotherapy through inhibition of oncogenic signaling pathways., PMID:33762321
A new reliable and highly specific monoclonal antibody to detect the C-terminal region of silencer of cytokine signaling 1., PMID:33714214
SOCS-1 inhibition of type I interferon restrains Staphylococcus aureus skin host defense., PMID:33690673
Inhibition of Dot1L Alleviates Fulminant Hepatitis Through Myeloid-Derived Suppressor Cells., PMID:33497867
Downregulation of SOCS gene expression can inhibit the formation of acute and persistent BDV infections., PMID:32910495
Fasciola hepatica Extracellular Vesicles isolated from excretory-secretory products using a gravity flow method modulate dendritic cell phenotype and activity., PMID:32898175
A homogeneous immunoassay for detection of the interaction between two tumor biomarkers of IGF1R-β and SOCS1., PMID:32700452
The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation., PMID:32606244
Association of a de novo nonsense mutation of the TRIM8 gene with childhood-onset focal segmental glomerulosclerosis., PMID:32193649
Effects of short-term fasting on the resistance of Nile tilapia (Oreochromis niloticus) to Streptococcus agalactiae infection., PMID:31546039
The IL-6 signaling complex is a critical driver, negative prognostic factor, and therapeutic target in diffuse large B-cell lymphoma., PMID:31515941
The impact of SOCS1 mutations in diffuse large B-cell lymphoma., PMID:31407320
Suppressor of cytokine signaling genes in renal transplant receivers: Association with transplant fate., PMID:31398463
Anti-double Stranded DNA Antibodies: Origin, Pathogenicity, and Targeted Therapies., PMID:31379858
Role of Tim-3 in Decidual Macrophage Functional Polarization During Abnormal Pregnancy With Toxoplasma gondii Infection., PMID:31354713
Disturbed Transcription of TLRs' Negative Regulators and Cytokines Secretion among TLR4- and 9-Activated PBMCs of Agammaglobulinemic Patients., PMID:31185757
Targeting Interleukin-6 Signaling in Clinic., PMID:30995492
SOCS3 ablation enhances DC-derived Th17 immune response against Candida albicans by activating IL-6/STAT3 in vitro., PMID:30851337
For research use only. Not for human or drug use.
