Catalog No.
YME27701
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Met1-Met770
Predicted molecular weight
115 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P42227
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor
A Naïve Phage Display Library-Derived Nanobody Neutralizes SARS-CoV-2 and Three Variants of Concern. [E]. [V]. [V]. [0]. [0]. [3]
Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization., PMID:40533059
Effects of Ganoderma spent substrate containing with polysaccharides and triterpenoids on the growth performance, antioxidant capacity and immunity level of chickens., PMID:40532998
Identifying pathogenic contributors of radiodermatitis ameliorated by Smad7-based targeting in canine and mouse models., PMID:40532891
Leishmania donovani infection-driven high levels of IL-10 causes hypoalbuminemia in human visceral leishmaniasis., PMID:40532289
STAT3 inhibition in combination with CD47 blockade inhibits osteosarcoma lung metastasis., PMID:40529368
Fbxo16 mediates degradation of NF-κB p65 subunit and inhibits inflammatory response in dendritic cells., PMID:40529355
Allosteric Covalent Inhibitors of the STAT3 Transcription Factor from Virtual Screening., PMID:40529081
Da-Yuan-Yin decoction suppresses NETs formation, inhibits the IL-23/JAK2/STAT3 signalling pathway, and modulates metabolic profiles and gut microbiota composition in damp-heat syndrome., PMID:40528429
Combined Manganese-Iron Exposure Reduced Oxidative Stress is Associated with the NRF2/NQO1 Pathway in Astrocytic C8-D1A Cells., PMID:40528129
Protective effect of Qiukui Taoren Recipe against acute renal injury by inhibiting oxidative stress, inflammation and apoptotic pathways., PMID:40527369
miRNA-548d-3p represses non-small cell lung cancer growth by perturbing DDX5-mediated pyroptosis through JAK2/STAT3 signaling., PMID:40527359
Integrative Network Pharmacology and Molecular Docking Analyses on the Mechanisms of San-Zhong-Kui-Jian-Tang in Treating Oral Squamous Cell Carcinoma., PMID:40526272
Elucidating the Action Mechanism of Shenling Baizhu Powder in the Treatment of Ulcerative Colitis Based on Network Pharmacology and Experimental Validation., PMID:40525448
Generation and Biological Characterization of an Anti-IL-6Rα Biosimilar Candidate Antibody., PMID:40524396
Systematic acupuncture explains acupuncture at Baihui (GV20) and Fengchi (GB20) targeting the inflammatory response to regulate migraine., PMID:40524299
Niclosamide Treatment Suppressed Metastatic, Apoptotic, and Proliferative Characteristics of MDA-MB-231 Cancer Stem Cells., PMID:40521512
Luteolin improves precancerous conditions of the gastric mucosa by binding STAT3 and inhibiting LCN2 expression., PMID:40520011
Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice., PMID:40518910
Dietary Litsea cubeba essential oil enhances growth, immunity, and intestinal health in channel catfish., PMID:40516798
Agmatine ameliorates sepsis-related intestinal injury via the AhR-STAT3-IL-10 pathway., PMID:40516501
The CXCL8-CXCR2 axis promotes M2 macrophage polarization in ovarian cancer via RASGRP4-mediated mTOR-STAT3 signaling., PMID:40515877
Discovery of Diaryl Piperidone-Sulfonamide as a Novel Dual-Target Inhibitor of STAT3/CAIX Inducing Ferroptosis in Triple-Negative Breast Cancer Cells., PMID:40515697
Ginsenoside Rg5 alleviates hypoxia-induced myocardial apoptosis by targeting STAT3 to promote Tyr705 phosphorylation., PMID:40514732
Early growth response 1 as a key regulator of PD-L1 expression and immune evasion in extranodal NK/T-cell lymphoma., PMID:40514360
Investigation of cognitive enhancements and mechanisms of kinsenoside in APP/PS1 mice through network pharmacology, in vivo experiments, and machine learning., PMID:40513940
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance., PMID:40512406
Protein Kinase CK2 Inhibition Represents a Pharmacological Chance for the Treatment of Skin Diseases., PMID:40508214
Prolonged Humid Heat Triggers Systemic Inflammation and Stress Signaling: Fluid Intake Modulates NF-κB, p38, JNK2, and STAT3α Pathways., PMID:40507928
The Roles of STAT3 and STAT5 in Breast Cancer., PMID:40507264
MiRNA-24 Downregulates KLF6 Affecting STAT3 Protein Expression and Phosphorylation Regulating Melanogenesis in Cashmere Goat coat., PMID:40506042
Gene signature-guided isolation identifies cucurbitacins as STAT3 inhibitors from Picria fel-terrae Lour., PMID:40505486
KSHV reprograms host RNA splicing via FAM50A to activate STAT3 and drive oncogenic cellular transformation., PMID:40503897
RNF213-Dependent EGFR and HER2 Activation Regulates Specific Downstream Signaling Pathways in Human Cancer Cells., PMID:40503863
EIF3B Promotes KRAS Gene Mutation-Driven Colon Adenocarcinoma Progression Through the TBK1 and PI3K/AKT Signaling Pathways., PMID:40503732
Dynamic VOC fingerprinting and mechanistic exploration of medicinal edible fungus Inonotus hispidus: A combination of HS-GC-IMS/MS multivariate analysis and network-based pharmacology., PMID:40499502
Crosstalk Between Th17 Cells and Renal Tubular Epithelial Cells Promotes Fibrotic Progression in IgA Nephropathy., PMID:40498423
Exploring the therapeutic potential of nutraceutical compounds (Curcumin, Quercetin, Epa, Zinc, and Vitamin D) in managing Celiac disease: insights from cellular mechanisms., PMID:40498343
HSP110 Regulates the Assembly of the SWI/SNF Complex., PMID:40498025
Upadacitinib for refractory Behçet's disease with myelodysplastic syndrome and trisomy 8/9: a case report and mechanistic insights., PMID:40496858
Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1-STAT3 signaling., PMID:40496853
mTORC1 and STAT3 signaling are indispensable for in vitro TGFβ1-dependent three-dimensional (3D) tendon constructs., PMID:40495482
Longitudinal progression of blood biomarkers reveals a key role of reactive astrocytosis in preclinical Alzheimer's disease., PMID:40494355
MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles., PMID:40493409
Exploration of the anticancer properties of Caffeic Acid in malignant mesothelioma cells., PMID:40493253
OZ-001 Suppresses the Growth of Triple-Negative Breast Cancer and Pancreatic Cancer by Targeting STAT3 Phosphorylation and the Calcium Signaling Pathway., PMID:40492404
Case Report: Biliary hemorrhage by intrahepatic pseudoaneurysm and asymptomatic right coronary artery pseudoaneurysm in a patient with STAT3 hyper IgE syndrome., PMID:40491905
Molsidomine ameliorates DEXA-induced insulin resistance: Involvement of HMGB1/JAK1/STAT3 signaling pathway., PMID:40490173
Pan-carcinoma data driven analysis reveals platelet-activating factor receptor (PTAFR) involvement in immunosuppressive tumor microenvironment signaling and clinical prognosis., PMID:40490119
Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation., PMID:40490058
History-dependent switch-like differentiation of keratinocytes in response to skin barrier damage., PMID:40489727
For research use only. Not for human or drug use.
