Catalog No.
YHF74601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn141-Pro333
Predicted molecular weight
22.82 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P83110
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
High-temperature requirement factor A3, Serine protease HTRA3, HTRA3, Pregnancy-related serine protease, PRSP
Remodeling of the extracellular matrix by serine proteases as a prerequisite for cancer initiation and progression., PMID:39500383
Exploring the Role of HtrA Family Genes in Cancer: A Systematic Review., PMID:38717523
HtrA3: a promising prognostic biomarker and therapeutic target for head and neck squamous cell carcinoma., PMID:37842043
A Pan-Cancer Analysis to Provide Insight into the Immunological Role and Prognostic Value of HTRA3., PMID:37606164
HTRA3 transcriptionally inhibited by FOXP1 suppresses tumorigenesis of osteosarcoma via the PTEN/PI3K/AKT pathway., PMID:37527738
Evidence of a role for CutRS and actinorhodin in the secretion stress response in Streptomyces coelicolor M145., PMID:37418299
Deficiency of HtrA3 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via TGF-β1/Smad Signaling Pathway., PMID:36823409
Overweight/obesity-related transcriptomic signature as a correlate of clinical outcome, immune microenvironment, and treatment response in hepatocellular carcinoma., PMID:36714595
Establishment of a prognostic prediction system based on tumor microenvironment of pancreatic cancer., PMID:36595826
Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts., PMID:36344049
The combination of DNA methylome and transcriptome revealed the intergenerational inheritance on the influence of advanced maternal age., PMID:36103411
Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration., PMID:36064790
mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis., PMID:35869629
High temperature requirement A3 attenuates hypoxia/reoxygenation induced injury in H9C2 cells via suppressing inflammatory responses., PMID:35764130
Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis., PMID:35672400
PPI-Affinity: A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding Affinity., PMID:35654412
The multifaced role of HtrA1 in the development of joint and skeletal disorders., PMID:35131488
Identification of three immune subtypes characterized by distinct tumor immune microenvironment and therapeutic response in stomach adenocarcinoma., PMID:35065254
Study on the Correlation between the Levels of HtrA3 and TGF-β2 in Late Pregnancy and Preeclampsia., PMID:35035835
A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation., PMID:34732858
Overview of Human HtrA Family Proteases and Their Distinctive Physiological Roles and Unique Involvement in Diseases, Especially Cancer and Pregnancy Complications., PMID:34639128
Altered DNA Methylation Profiles in SF3B1 Mutated CLL Patients., PMID:34502260
HtrA serine proteases in cancers: A target of interest for cancer therapy., PMID:34243596
The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation., PMID:34150754
HTRA family proteins in pregnancy outcome., PMID:33915357
Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families., PMID:33837273
Hsa-miR-494-3p attenuates gene HtrA3 transcription to increase inflammatory response in hypoxia/reoxygenation HK2 Cells., PMID:33462352
Transcriptional landscape of the embryonic chicken Müllerian duct., PMID:33008304
A Five-Gene Signature Based on Stromal/Immune Scores in the Tumor Microenvironment and Its Clinical Implications for Liver Cancer., PMID:32758021
Identification of differentially expressed metastatic genes and their signatures to predict the overall survival of uveal melanoma patients by bioinformatics analysis., PMID:32685390
Uterine fibroids may play a protecting role against endometrial carcinoma in Chinese women with gynecological diseases., PMID:32608475
Expression of HTRA Genes and Its Association with Microsatellite Instability and Survival of Patients with Colorectal Cancer., PMID:32486357
A distinct concerted mechanism of structural dynamism defines activity of human serine protease HtrA3., PMID:31899476
CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence., PMID:31811121
Identification of a distal allosteric ligand binding pocket in HtrA3., PMID:31280864
The HtrA3 protease promotes drug-induced death of lung cancer cells by cleavage of the X-linked inhibitor of apoptosis protein (XIAP)., PMID:31260151
Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling., PMID:31242033
Long intergenic non‑coding RNA 00467 promotes lung adenocarcinoma proliferation, migration and invasion by binding with EZH2 and repressing HTRA3 expression., PMID:31180543
Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth., PMID:31013509
Antagonism between HTRA3 and TGFβ1 Contributes to Metastasis in Non-Small Cell Lung Cancer., PMID:30940659
Serum podocalyxin for early detection of preeclampsia at 11-13 weeks of gestation., PMID:30415742
The crystal structure of an essential high-temperature requirement protein HtrA1 (Rv1223) from Mycobacterium tuberculosis reveals its unique features., PMID:30198900
Immune response against HtrA proteases in children with cutaneous mastocytosis., PMID:30148508
Hypoxia is involved in the reduction of HtrA3 in patients with endometrial hyperplasia and cancer., PMID:30139517
Letter to the Editor: "Placental HtrA3 Is Regulated by Oxygen Tension and Serum Levels Are Altered During Early Pregnancy in Women Destined to Develop Preeclampsia"., PMID:29546279
HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin., PMID:29477555
Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes., PMID:29266444
Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression., PMID:28860718
Selection of Effective HTRA3 Activators Using Combinatorial Chemistry., PMID:28741928
HtrA3 stromal expression is correlated with tumor budding in stage II colorectal cancer., PMID:28716573
For research use only. Not for human or drug use.
