Catalog No.
YHB97501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser1386-Pro1467
Predicted molecular weight
11.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P02458
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
COL2A1, Collagen alpha-1(II) chain, Alpha-1 type II collagen
Therapeutic potential of miR-204-5p in intervertebral disc degeneration: targeting the SSRP1/NF-κB pathway to inhibit apoptosis., PMID:40514727
TGF-β1/BSA coating modulates multi-phasic scaffolds for osteochondral tissue regeneration., PMID:40502370
Chicago Sky Blue 6B modulates MAPK/NF-kB pathway in rat knee osteoarthritis., PMID:40500381
Thrombospondin-1 mitigates osteoarthritis progression by inhibiting mechanical stress-induced chondrocyte ferroptosis via the integrin/YAP pathway., PMID:40475787
Molecular Mechanisms of Intervertebral Disc Degeneration: Significance of SPARC Gene Expression., PMID:40452200
Chondroitin sulfate/hyaluronic acid/carboxymethylcellulose macroporous cryogels for controlled delivery of TGF-β1 and IGF-1 to induce chondrogenic differentiation of adipose-derived stem cells in cartilage tissue engineering., PMID:40449777
The Characterization of Serum-Free Media on Human Mesenchymal Stem Cell Fibrochondrogenesis., PMID:40428164
RNA Analysis Enables Resolution and Reclassification of Reportedly Benign Synonymous Variants., PMID:40400350
Syndromic forms of inherited retinal dystrophies: a comprehensive molecular diagnosis of consanguineous Pakistani families using capture panel sequencing., PMID:40384762
Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p In Vitro., PMID:40372627
Naringin Mitigates Chondrocyte Apoptosis in Osteoarthritis by Suppressing the miR-29a-3p-Bax Pathway., PMID:40358971
Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration., PMID:40356987
PDGF-Releasing Hydrogels for Enhanced Proliferation of Human Nucleus Pulposus Cells., PMID:40344482
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics., PMID:40327988
BMP and WNT signaling are involved in tracheal cartilage development in chicken embryos., PMID:40324741
Effect of Plasminogen Activator Inhibitor-1 on extracellular matrix homeostasis in scaffold-free spheroids from human chondrocytes., PMID:40316399
Orbital mesenchymal chondrosarcoma and its specific fusion gene HEY1-NCOA2., PMID:40301759
Effects of Oligomeric Proanthocyanidins on Cadmium-Induced Extracellular Matrix Damage via Inhibiting the ERK1/2 Signaling Pathway in Chicken Chondrocytes., PMID:40284819
LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis., PMID:40281518
Substrate Stiffness Modulates TGF-β1-Induced Lineage Specification in Multipotent Vascular Stem Cells., PMID:40277936
Enhanced cartilage repair using gelatin methacryloyl hydrogels combined with icariin and magnesium-doped bioactive glass., PMID:40235097
GPNMB Suppresses Inflammation and Extracellular Matrix Degradation in Nucleus Pulposus Cells by Inhibiting Pro-Inflammatory Cytokine Production and Activation of the NF-κB Signaling Pathway., PMID:40234039
Gel@CAT-L hydrogel mediates mitochondrial unfolded protein response to regulate reactive oxygen species and mitochondrial homeostasis in osteoarthritis., PMID:40222260
Synovial Fibroblast Extracellular Vesicles Induce Inflammation via Delivering miR-21-5p in Osteoarthritis., PMID:40214473
SEMA6D modulates extracellular matrix metabolism in osteoarthritis by inhibiting the AGT/AGTR1a/IL-1β axis., PMID:40184436
Red-light LED therapy promotes wound regeneration by upregulating COL1A1, COL2A1, VEGF and reducing IL-1β for anti-inflammation., PMID:40175683
Whole-exome sequencing screening for candidate genes and potential pathogenic variants associated with early-onset high myopia in 47 Chinese families., PMID:40175531
MiR-455-5p Mitigates Interleukin-1 β-induced Chondrocyte Damage Linked to Osteoarthritis by Targeting TNFAIP8., PMID:40170451
Chondrocalcin: Insights into its regulation and multi-function in cartilage and bone., PMID:40157027
TRIM15 drives chondrocyte senescence and osteoarthritis progression., PMID:40138455
Advance in candidate genes in mandibular retrognathism: A systematic review., PMID:40132276
Salvianolic acid A facilitates cartilage repair in knee osteoarthritis model rats by promoting WDR5 expression., PMID:40129684
Selenium deficiency exacerbates cartilage degradation caused by HT-2 toxin via notch signaling pathway activation., PMID:40105990
Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head., PMID:40102965
Distinguishing syndromic and nonsyndromic cleft palate through analysis of protein-altering de novo variants in 816 trios., PMID:40093200
Unraveling the crucial role of SDF-1 in osteoarthritis progression: IL6/HIF-1α positive feedback and chondrocyte ferroptosis., PMID:40058106
SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis., PMID:40025280
Blockade of the vaspin-AP-1 axis inhibits arthritis development., PMID:40025171
5-hydroxymethylfurfural attenuates osteoarthritis by upregulating of glucose metabolism in chondrocytes., PMID:40020627
Elevated expression of Piezo1 activates the cGAS-STING pathway in chondrocytes by releasing mitochondrial DNA., PMID:39978573
Identification of the key role of IL-17RB in the treatment of osteoarthritis with Shaoyao Gancao decoction: Verification based on RNA-seq and bioinformatics analysis., PMID:39964979
Clinical Features of Seven COL2A1 Variations in Chinese Children With Type II Collagen Disorders., PMID:39953747
Pulsed electromagnetic field ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway., PMID:39953605
Investigating the impact of Premolis semirufa caterpillar bristle toxins on human chondrocyte activation and inflammation., PMID:39928679
MLL4 regulates postnatal palate growth and midpalatal suture development., PMID:39925741
Mutation in the COL2A1 gene is associated with acetabular dysplasia., PMID:39902299
Injectable Self-Assembling Procyanidin Nanospheres for Effective Osteoarthritis Treatment., PMID:39895981
Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway., PMID:39844325
Proteins Involved in Endothelial Function and Inflammation Are Implicated in Cerebral Small Vessel Disease., PMID:39818967
SUMOylated GLUT1 inhibited the glycometabolism disorder in chondroctyes during osteoarthritis., PMID:39797965
For research use only. Not for human or drug use.
