Catalog No.
VMD30401
Species reactivity
Mouse
Host species
Mouse
Isotype
IgG
Clonality
Monoclonal
Target
Bispecific, Aida, CD223, sLAG-3, Lag3, Lymphocyte activation gene 3 protein, Activation-induced cytidine deaminase-linked autoimmunity protein, LAG-3, Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q61790 & Q02242
Applications
FuncS
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0273
Clinical, tumor and product features associated with outcomes after axicabtagene ciloleucel therapy in follicular lymphoma., PMID:40536814
Single-Cell Profiling of the Microenvironment in High-Risk Neuroblastoma., PMID:40536225
The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint., PMID:40533767
Tumor-Associated Glycan Exploits Adenosine Receptor 2A Signaling to Facilitate Immune Evasion., PMID:40532063
Radio-chemotherapy and metformin selectively modulate the heterogeneous landscape of glioma with ribosome biogenesis, long non coding RNA and immune-escape markers as major player., PMID:40520013
Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection., PMID:40519925
Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human., PMID:40518289
Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade., PMID:40517319
Exploring new frontiers in LAG-3 biology and therapeutics., PMID:40514283
Impact of short-term air pollution exposure on premature rupture of membranes in the North China Plain, 2015-2021: a multicity case-crossover study., PMID:40511528
Cross-Correlation Analysis of Monthly Google Search Volume and Suicide in Taiwan, 2012-2022., PMID:40510803
Immune Checkpoint Inhibitors in the Treatment of Advanced Melanoma in Older Patients: An Overview of Published Data., PMID:40507314
The dynamics of brain T cell populations during the course of rasmussen encephalitis: from expansion to exhaustion., PMID:40506704
Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC., PMID:40500691
SGSM1 as a pan-cancer biomarker: multi-omics insights into immune regulation, prognostic value, and therapeutic implications., PMID:40500484
Uncovering PD-L1 among immune cell predictive biomarkers and actionable genetic alterations in anal squamous-cell carcinomas in the era of immunotherapy., PMID:40499464
Regulatory T cells in the tumour microenvironment., PMID:40494998
Enhanced anti-tumor activity by zinc finger repressor-driven epigenetic silencing of immune checkpoints and TGFBR2 in CAR-T cells and TILs., PMID:40487483
LAG3 Is Expressed on Muscle-Infiltrating Cytotoxic T Cells, but Scarce on Circulating T Cells, in Patients With Inclusion Body Myositis., PMID:40485502
Adaptive immune changes in colorectal cancer: a focus on T and B cell activation genes., PMID:40484866
Immunohistochemical expression of PD1, LAG3, and CTLA4 in diffuse large B cell lymphoma, clinicopathological correlation, and prognostic value., PMID:40481915
CD70 CAR-T cells empowered by TS-2021 through ex vivo transduction show potent antitumor efficacy against glioblastoma., PMID:40474210
Successful use of nivolumab and relatlimab as salvage therapy for metastatic uveal melanoma., PMID:40465233
Construction and validation of a lipid metabolism-related genes prognostic signature for skin cutaneous melanoma., PMID:40460484
Tumor microenvironment of non-small cell lung cancer impairs immune cell function among people with HIV., PMID:40459946
The role of immune checkpoint molecules in PRRSV-2-induced immune modulation: insights from comparative in vivo evaluation including NADC34-like PRRSV., PMID:40459260
Immune checkpoint molecules and spatial transcriptome profiles according to BRAF status in acral melanoma., PMID:40459254
TERT promoter methylation predicts overall survival, immune cell infiltration and response to immunotherapy in clear cell renal cell carcinoma., PMID:40448175
Inhibition of head and neck squamous cell carcinoma by Bruton's tyrosine kinase inhibitor ibrutinib is associated with reduction of immunosuppressive T cells., PMID:40445239
New Standards in the Treatment of Advanced Metastatic Melanoma: Immunotherapy and BRAF-Targeted Therapies as Emerging Paradigms., PMID:40442907
Tertiary lymphoid structures signature predicts prognosis and clinical benefits from adjuvant chemotherapy and PD-L1 blockade in colorectal adenocarcinoma., PMID:40440077
Predictive biomarkers in the era of immunotherapy for gastric cancer: current achievements and future perspectives., PMID:40438098
Immune Modulation During Treatment with Enzalutamide Alone or with Radium-223 in Patients with Castration Resistant Prostate Cancer., PMID:40427227
Gastric Carcinoma., PMID:40423781
LAG3 facilitates MHCII trogocytosis with the assistance of ER-PM junction., PMID:40420606
Comprehensive analysis of immune checkpoint molecules profiles phenotype and function of exhausted T cells in enzootic bovine leukosis., PMID:40420409
Over-activation and dysfunction of platelet-NK cell aggregates in HIV-infected individuals., PMID:40420100
[A novel fully human LAG-3 monoclonal antibody LBL-007 combined with PD-1 antibody inhibits proliferation, migration and invasion of tumor cells via blocking NF-κB pathway]., PMID:40415618
Unravelling T cell exhaustion through co-inhibitory receptors and its transformative role in cancer immunotherapy., PMID:40415479
Adjuvant Immunotherapy in Microsatellite Instability-High Colon Cancer: A Literature Review on Efficacy, Challenges, and Future Directions., PMID:40415356
Breaking the immune desert: Strategies for overcoming the immunological challenges of pancreatic cancer., PMID:40412630
LAG3 as a marker of immune activation in esophageal squamous carcinoma treated with concurrent chemoradiotherapy., PMID:40411616
[New therapeutic approaches in the neoadjuvant/adjuvant treatment of melanoma]., PMID:40407846
Facts & Hopes: towards the next quantum leap in melanoma., PMID:40407722
Highly sensitive live-cell imaging-based cytotoxicity assay enables functional validation of rare epitope-specific CTLs., PMID:40406125
Immune checkpoint inhibitor (ICI) therapy in central nervous system cancers: State-of-the-art and future outlook., PMID:40394797
Nivolumab and Relatlimab for the treatment of patients with unresectable or metastatic mismatch repair proficient colorectal cancer., PMID:40388545
KCNC3 as a prognostic indicator and a predictive marker for immunotherapy in colorectal cancer., PMID:40386598
Unravelling the tumor microenvironment and PD-L1 expression across tissue type in high-grade serous ovarian cancer in the NeoPembrOV/GINECO phase II randomized trial., PMID:40378056
Immune checkpoint inhibitors and immunosuppressive tumor microenvironment: current challenges and strategies to overcome resistance., PMID:40376861
For research use only. Not for human or drug use.
