Catalog No.
YHA58702
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Cys1067-Asp1251
Predicted molecular weight
21.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43157
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SEP, Semaphorin receptor SEP, PLXN5, PLXNB1, Plexin-B1, KIAA0407
Smoking aggravates neovascular age-related macular degeneration via Sema4D-PlexinB1 axis-mediated activation of pericytes., PMID:40121188
Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization., PMID:39865283
Participation of Semaphorin Family and Plexins in the Clinical Course of Patients with Inflammatory Bowel Disease., PMID:39596507
PLXNB1/SEMA4D signals mediate interactions between malignant epithelial and immune cells to promote colorectal cancer liver metastasis., PMID:39443302
The metastasis-promoting P1597L mutation in PlexinB1 enhances Ras activity., PMID:39138404
B-type Plexins Regulate Mitosis via RanGTPase., PMID:39136653
PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination., PMID:38874583
Identifying therapeutic target genes for migraine by systematic druggable genome-wide Mendelian randomization., PMID:38867170
Sympathetic hyperinnervation drives abdominal aortic aneurysm development by promoting vascular smooth muscle cell phenotypic switching., PMID:38821358
Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer's disease., PMID:38802590
A phase 1/2 study of pepinemab in children, adolescents, or young adults with recurrent or refractory solid tumors: A children's oncology group consortium report (ADVL1614)., PMID:38520670
Former smoking associated with epigenetic modifications in human granulosa cells among women undergoing assisted reproduction., PMID:38424222
Plexin B1 controls Treg numbers, limits allergic airway inflammation, and regulates mucins., PMID:38259471
Semaphorin4A promotes lung cancer by activation of NF-κB pathway mediated by PlexinB1., PMID:37901456
Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models., PMID:36936664
MiR-362-5p inhibits cartilage repair in osteoarthritis via targeting plexin B1., PMID:36523183
De novo Fc-based receptor dimerizers differentially modulate PlexinB1 function., PMID:35981535
An Integrated Analysis of Prognostic Signature and Immune Microenvironment in Tongue Squamous Cell Carcinoma., PMID:35912229
An antagonistic monoclonal anti-Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis., PMID:35850304
SEMA4D/PlexinB1 promotes AML progression via activation of PI3K/Akt signaling., PMID:35794581
Essential role of Rnd1 in innate immunity during viral and bacterial infections., PMID:35654795
Circular RNA circ_0065378 upregulates tumor suppressor candidate 1 by competitively binding with miR-4701-5p to alleviate colorectal cancer progression., PMID:35434854
Increased BMSC exosomal miR-140-3p alleviates bone degradation and promotes bone restoration by targeting Plxnb1 in diabetic rats., PMID:35236339
PLXNB1 mutations in the etiology of idiopathic hypogonadotropic hypogonadism., PMID:35170806
Inhibition of Semaphorin 4D/Plexin-B1 signaling inhibits the subchondral bone loss in early-stage osteoarthritis of the temporomandibular joint., PMID:35151027
Sema4D/Plexin-B1 promotes the progression of osteosarcoma cells by activating Pyk2-PI3K-AKT pathway., PMID:34854398
Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells., PMID:34802461
3D disorganization and rearrangement of genome provide insights into pathogenesis of NAFLD by integrated Hi-C, Nanopore, and RNA sequencing., PMID:34729306
[Peritoneal recurrence prediction for colon cancer based on immunoexpression]., PMID:34175025
Barcoded viral tracing of single-cell interactions in central nervous system inflammation., PMID:33888612
Mechanochemical control of epidermal stem cell divisions by B-plexins., PMID:33637728
Neutrophil-Derived Semaphorin 4D Induces Inflammatory Cytokine Production of Endothelial Cells via Different Plexin Receptors in Kawasaki Disease., PMID:33381571
The emerging roles of semaphorin4D/CD100 in immunological diseases., PMID:33258873
Plexin-Bs enhance their GAP activity with a novel activation switch loop generating a cooperative enzyme., PMID:32601713
Sema4D Aggravated LPS-Induced Injury via Activation of the MAPK Signaling Pathway in ATDC5 Chondrocytes., PMID:32382577
Correlations Among Genotype and Outcome in Chinese Male Patients With Congenital Hypogonadotropic Hypogonadism Under HCG Treatment., PMID:32171629
Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy., PMID:31943789
PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor., PMID:31861264
Upregulation of IFN-β induced by Sema4D-dependent partial Erk1/2 inhibition promotes NO production in microglia., PMID:31708102
Local Ordering at the N-H Sites of the Rho GTPase Binding Domain of Plexin-B1: Impact of Dimerization., PMID:31469564
Cognition may link cortical IGFBP5 levels with motor function in older adults., PMID:31404102
Semaphorin 4A Stabilizes Human Regulatory T Cell Phenotype via Plexin B1., PMID:31236543
Transcriptome Analysis Reveals Novel Genes Associated with Cartilage Degeneration in Posttraumatic Osteoarthritis Progression., PMID:31104480
CD100-plexin-B1 induces epithelial-mesenchymal transition of head and neck squamous cell carcinoma and promotes metastasis., PMID:30981760
Sema4D/PlexinB1 promotes endothelial differentiation of dental pulp stem cells via activation of AKT and ERK1/2 signaling., PMID:30937968
Brain IGFBP-5 modifies the relation of depressive symptoms to decline in cognition in older persons., PMID:30875674
Association between prognosis and SEMA4D/Plexin-B1 expression in various malignancies: A meta-analysis., PMID:30762724
The role of sema4D in vasculogenic mimicry formation in non-small cell lung cancer and the underlying mechanisms., PMID:30374974
The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases., PMID:30353093
Prostate cancer tissues with positive TMPRSS2-ERG-gene-fusion status may display enhanced nerve density., PMID:30241953
For research use only. Not for human or drug use.
