Catalog No.
VHF12002
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Target
CDH11, OSF-4, Osteoblast cadherin, Cadherin-11, OB-cadherin
Concentration
1.23 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P55287
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SYN0012
Cadherin-11 targeted cell-specific liposomes enabled skin fibrosis treatment by inducing apoptosis., PMID:38648957
Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma., PMID:37812652
Stricturing Crohn's Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions., PMID:37507073
Cadherin-11-Interleukin-6 Signaling between Cardiac Fibroblast and Cardiomyocyte Promotes Ventricular Remodeling in a Mouse Pressure Overload-Induced Heart Failure Model., PMID:37047522
Targeting breast and pancreatic cancer metastasis using a dual-cadherin antibody., PMID:36256815
The Effects of Mechanical Stretch on Integrins and Filopodial-Associated Proteins in Normal and Glaucomatous Trabecular Meshwork Cells., PMID:35573666
Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice., PMID:33307028
Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness., PMID:33060832
Cadherin-11 cooperates with inflammatory factors to promote the migration and invasion of fibroblast-like synoviocytes in pigmented villonodular synovitis., PMID:32929367
A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer., PMID:32665033
Boron doped silver-copper alloy nanoparticle targeting intracellular S. aureus in bone cells., PMID:32275737
Cadherin-11 binds to PDGFRβ and enhances cell proliferation and tissue regeneration via the PDGFR-AKT signaling axis., PMID:31930567
Cadherin-11 blockade reduces inflammation-driven fibrotic remodeling and improves outcomes after myocardial infarction., PMID:31534054
Monospecific antibody targeting of CDH11 inhibits epithelial-to-mesenchymal transition and represses cancer stem cell-like phenotype by up-regulating miR-335 in metastatic breast cancer, in vitro and in vivo., PMID:31248373
Cadherin-11 as a regulator of valve myofibroblast mechanobiology., PMID:30359089
Anti-Tumour Necrosis Factor Therapy for Dupuytren's Disease: A Randomised Dose Response Proof of Concept Phase 2a Clinical Trial., PMID:29983350
Targeting of cadherin-11 decreases skin fibrosis in the tight skin-1 mouse model., PMID:29112946
Impact of Detergents on Membrane Protein Complex Isolation., PMID:29110486
Proteomics Profiling of Exosomes from Primary Mouse Osteoblasts under Proliferation versus Mineralization Conditions and Characterization of Their Uptake into Prostate Cancer Cells., PMID:28675788
Cadherin-11 as a therapeutic target in chronic, inflammatory rheumatic diseases., PMID:28115292
Cadherin-11 modulates cell morphology and collagen synthesis in periodontal ligament cells under mechanical stress., PMID:27689865
Collagen triple helix repeat containing 1 is a new promigratory marker of arthritic pannus., PMID:27430622
Cadherin 11 Involved in Basement Membrane Damage and Dermal Changes in Melasma., PMID:26671310
Cadherin-11 regulates the metastasis of Ewing sarcoma cells to bone., PMID:26092671
[Etanercept inhibits synovial inflammation and reduces the expression of adhesion related molecules in synovial tissues of patients with rheumatoid arthritis]., PMID:25854571
Quantitative analysis of cadherin-11 and β-catenin signalling during proliferation of rheumatoid arthritis-derived synovial fibroblast cells., PMID:25787991
The role of gap junctions and mechanical loading on mineral formation in a collagen-I scaffold seeded with osteoprogenitor cells., PMID:25752490
Angiomotin is a novel component of cadherin-11/β-catenin/p120 complex and is critical for cadherin-11-mediated cell migration., PMID:25466890
Universal antibody conjugation to nanoparticles using the Fcγ receptor I (FcγRI): quantitative profiling of membrane biomarkers., PMID:25215471
Roles of transforming growth factor-β1 and OB-cadherin in porcine cardiac valve myofibroblast differentiation., PMID:25008089
Estradiol-potentiated cadherin-11 in synovial membrane involves in temporomandibular joint inflammation in rats., PMID:25006014
Identification of cadherin 11 as a mediator of dermal fibrosis and possible role in systemic sclerosis., PMID:24757152
Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies., PMID:24681547
Cadherin-11 in renal cell carcinoma bone metastasis., PMID:24587095
ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression., PMID:24130169
Cadherin-11 regulates motility in normal cortical neural precursors and glioblastoma., PMID:23951053
Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis., PMID:23913163
Chondroitin sulfate-E fine-tunes osteoblast differentiation via ERK1/2, Smad3 and Smad1/5/8 signaling by binding to N-cadherin and cadherin-11., PMID:22440395
Modulation of matrix metalloproteinase production by rheumatoid arthritis synovial fibroblasts after cadherin 11 engagement., PMID:22127696
Cadherin-11 contributes to pulmonary fibrosis: potential role in TGF-β production and epithelial to mesenchymal transition., PMID:21990376
The TAg-RB murine retinoblastoma cell of origin has immunohistochemical features of differentiated Muller glia with progenitor properties., PMID:21862643
A high-performance microsystem for isolating circulating tumor cells., PMID:21837324
Enhancement of osteoclastogenic activity in osteolytic prostate cancer cells by physical contact with osteoblasts., PMID:21206493
A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata., PMID:20693980
N-cadherin is expressed on human hematopoietic progenitor cells and mediates interaction with human mesenchymal stromal cells., PMID:20116358
MicroRNA-145 suppresses cell invasion and metastasis by directly targeting mucin 1., PMID:19996288
Cadherin-11 up-regulation in overactive bladder suburothelial myofibroblasts., PMID:19450843
Cadherin-11 promotes the metastasis of prostate cancer cells to bone., PMID:18708358
Expression of the extracellular domain of OB-cadherin as an Fc fusion protein using bicistronic retroviral expression vector., PMID:18620062
Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone., PMID:18575746
For research use only. Not for human or drug use.
