Catalog No.
YHG12101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn334-Ser654
Predicted molecular weight
39.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q07343
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PDE4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, PDE32, DPDE4
Individual contribution of PDE4B and PDE4D subfamilies to the prevention of object location memory impairments induced by sleep deprivation., PMID:40490297
Comprehensive computational strategies for multi-target drug discovery in inflammatory bowel disease utilizing bioactive compounds., PMID:40319156
Dialkyloxyphenyl hybrids as PDE4B inhibitors: Design, synthesis, in vitro/in vivo anti-inflammatory activity and in silico insights., PMID:40311245
Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance., PMID:40246973
Insights Into the Cellular and Molecular Mechanisms Behind the Antifibrotic Effects of Nerandomilast., PMID:40239038
Daily acute intermittent hypoxia elicits age & sex-dependent changes in molecules regulating phrenic motor plasticity., PMID:40204197
Cross-Sensitization between Binge Eating and Binge Drinking in a Novel C57BL/6NJ Murine Model of Disease Comorbidity Requires PDE4B Activation., PMID:40164512
Role of PDE4 Family in Cardiomyocyte Physiology and Heart Failure., PMID:40136709
Microglial circDlg1 modulates neuroinflammation by blocking PDE4B ubiquitination-dependent degradation associated with Alzheimer's disease., PMID:40093898
PDE4D inhibition ameliorates cardiac hypertrophy and heart failure by activating mitophagy., PMID:40015131
Novel application of cycloastragenol target microglia for the treatment of Alzheimer's disease: Evidence from single-cell analysis, network pharmacology and experimental assessment., PMID:39970860
PDE4B promotes JNK/NLRP3 activation in the nucleus pulposus and mediates intervertebral disc degeneration., PMID:39962094
Manshenkang granules alleviate fibrosis in chronic renal failure rats by regulating the PDE4b/cAMP pathway., PMID:39961423
PDE4B Modulates Phosphorylation of p65 (Ser468) via cAMP/PKA in Acute Lung Injury., PMID:39956855
PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice., PMID:39947489
Inhibition of PDE4B ameliorates cognitive defects in the model of alcoholic dementia in 3xTg-AD mice via PDE4B/cAMP/PKA signaling., PMID:39921664
Temporal and spatial expression of Phosphodiesterase-4B after sciatic nerve compression in rats and its mechanism of action on sciatic nerve repair., PMID:39914666
PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration., PMID:39893206
Pde4b-regulated cAMP signaling pathway in the AUDGABA-S1TrSst circuit underlies acute-stress-induced anxiety-like behavior., PMID:39891910
Shenghui decoction inhibits neuronal cell apoptosis to improve Alzheimer's disease through the PDE4B/cAMP/CREB signaling pathway., PMID:39787692
Potential of phosphodiesterase 4B inhibition in the treatment of progressive pulmonary fibrosis., PMID:39745090
Rationale for phosphodiesterase-4 inhibition as a treatment strategy for interstitial lung diseases associated with rheumatic diseases., PMID:39719300
Menisoxoisoaporphine A, a novel oxoisoaporphine alkaloid from Menispermi Rhizoma, inhibits inflammation by targeting PDE4B., PMID:39691395
Machine Learning Integration with Single-Cell Transcriptome Sequencing Datasets Reveals the Impact of Tumor-Associated Neutrophils on the Immune Microenvironment and Immunotherapy Outcomes in Gastric Cancer., PMID:39684426
Chemical, Biochemical, and Structural Similarities and Differences of Dermatological cAMP Phosphodiesterase-IV Inhibitors., PMID:39608668
PDE4B abrogation extenuates angiotensin II-induced endothelial dysfunction related to hypertension through up-regulation of AMPK/Sirt1/Nrf2/ARE signaling., PMID:39591723
Unveiling the role of phytochemicals in autism spectrum disorder by employing network pharmacology and molecular dynamics simulation., PMID:39570464
Identifying a CD8T cell signature in the tumor microenvironment to forecast gastric cancer outcomes from sequencing data., PMID:39554559
COF-SO3H-Catalyzed Synthesis of Pyrazoline-Pyridine Hybrids with Dual Antioxidant and Anti-Inflammatory Activity Targeting PDE4B., PMID:39523465
Rationale design and synthesis of new roflumilast analogues as preferential selective and potent PDE-4B inhibitors., PMID:39467506
Exploring the material basis and molecular targets of Changma Xifeng tablet in treating Tourette syndrome: an integrative approach of network pharmacology and miRNA analysis., PMID:39436634
Nobiletin, as a Novel PDE4B Inhibitor, Alleviates Asthma Symptoms by Activating the cAMP-PKA-CREB Signaling Pathway., PMID:39408735
GZMA suppressed GPX4-mediated ferroptosis to improve intestinal mucosal barrier function in inflammatory bowel disease., PMID:39367435
Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion., PMID:39287745
PET imaging in rat brain shows opposite effects of acute and chronic alcohol exposure on phosphodiesterase-4B, an indirect biomarker of cAMP activity., PMID:39285225
PDE4B Missense Variant Increases Susceptibility to Post-traumatic Stress Disorder-Relevant Phenotypes in Mice., PMID:39256048
Hua-Shi-Bai-Du decoction inactivates NLRP3 inflammasome through inhibiting PDE4B in macrophages and ameliorates mouse acute lung injury., PMID:39236558
Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations., PMID:39223490
Potential of phosphodiesterase 4B inhibitors in the treatment of interstitial lung disease associated with autoimmune diseases., PMID:39212123
Expression Pattern of PDE4B, PDE4D, and SFRP5 Markers in Colorectal Cancer., PMID:39202484
Phosphodiesterase 4 is overexpressed in human keloids and its inhibition reduces fibroblast activation and skin fibrosis., PMID:39197814
PDE4B inhibition by nerandomilast: Effects on lung fibrosis and transcriptome in fibrotic rats and on biomarkers in human lung epithelial cells., PMID:39183442
Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal Inflammatory Response., PMID:39126032
Targeting next-generation PDE4 inhibitors in search of potential management of rheumatoid arthritis and psoriasis., PMID:39111119
Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice., PMID:38920631
Therapeutic perspectives on PDE4B inhibition in adipose tissue dysfunction and chronic liver injury., PMID:38878273
Discovery of 7-alkoxybenzofurans as PDE4 inhibitors with hepatoprotective activity in D-GalN/LPS-induced hepatic sepsis., PMID:38861808
Differential Downregulation of β1-Adrenergic Receptor Signaling in the Heart., PMID:38860414
Establishment of a neutrophil extracellular trap-related prognostic signature for colorectal cancer liver metastasis and expression validation of CYP4F3., PMID:38795162
Altered Expression of PDE4 Genes in Schizophrenia: Insights from a Brain and Blood Sample Meta-Analysis and iPSC-Derived Neurons., PMID:38790238
For research use only. Not for human or drug use.
