Catalog No.
FHK23212
Host species
Mouse
Isotype
IgG2a, lambda
Clonality
Monoclonal
Conjugation
PE
Target
Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Protein WSL-1, LARD, Lymphocyte-associated receptor of death, Tumor necrosis factor receptor superfamily member 25, Apo-3, Protein WSL, APO3, DR3, TNFRSF12, WSL, TNFRSF25, Death receptor 3, DDR3, WSL1
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
Q93038
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
PTX25
Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8+ T cells and inhibited tumor growth., PMID:39142717
Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists., PMID:37795079
Pancreatic islet transplantation in type 1 diabetes: 20-year experience from a single-centre cohort in Canada., PMID:35588757
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) agonists in islet transplantation: Endogenous in vivo regulatory T cell expansion promotes prolonged allograft survival., PMID:34965021
Role of Myeloid-Derived Suppressor Cells in High-Dose-Irradiated TRAMP-C1 Tumors: A Therapeutic Target and an Index for Assessing Tumor Microenvironment., PMID:33188861
TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses., PMID:33177161
The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens., PMID:32397343
Activation of the DR3-TL1A Axis in Donor Mice Leads to Regulatory T Cell Expansion and Activation With Reduction in Graft-Versus-Host Disease., PMID:31379829
TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity., PMID:30972074
Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn's Disease., PMID:30295722
Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction., PMID:29135326
Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation., PMID:28219835
Effect of infusion of monoclonal antibodies to tumour necrosis factor-receptor super family 25 on graft rejection in allo-immune mice receiving autologous marrow transplantation., PMID:27859243
TNFSF15 suppresses VEGF production in endothelial cells by stimulating miR-29b expression via activation of JNK-GATA3 signals., PMID:27589684
Renal microRNA- and RNA-profiles in progressive chronic kidney disease., PMID:26707063
Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia., PMID:26393680
Tumor Necrosis Factor-like Cytokine TL1A and Its Receptors DR3 and DcR3: Important New Factors in Mucosal Homeostasis and Inflammation., PMID:26099067
Tumour necrosis factor superfamily member 15 (Tnfsf15) facilitates lymphangiogenesis via up-regulation of Vegfr3 gene expression in lymphatic endothelial cells., PMID:26096340
Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease., PMID:26063163
The molecular basis for development of proinflammatory autoantibodies to progranulin., PMID:26005049
Co-stimulation with TNF receptor superfamily 4/25 antibodies enhances in-vivo expansion of CD4+CD25+Foxp3+ T cells (Tregs) in a mouse study for active DNA Aβ42 immunotherapy., PMID:25595257
Long-Term Tolerance and Skin Allograft Survival in CD200tg Mice After Autologous Marrow Transplantation., PMID:25340612
Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis., PMID:25161149
Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis., PMID:24850426
TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis., PMID:24832108
Gene expression profiling in peripheral blood mononuclear cells of patients with common variable immunodeficiency: modulation of adaptive immune response following intravenous immunoglobulin therapy., PMID:24831519
TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses., PMID:24140642
Anti-cancer effect and apoptosis induction of cordycepin through DR3 pathway in the human colonic cancer cell HT-29., PMID:23941773
The TNF-family cytokine TL1A inhibits proliferation of human activated B cells., PMID:23565196
Cloning, expression, and functional characterization of TL1A-Ig., PMID:23319737
Tregs expanded in vivo by TNFRSF25 agonists promote cardiac allograft survival., PMID:22902792
TNFRSF25 agonistic antibody and galectin-9 combination therapy controls herpes simplex virus-induced immunoinflammatory lesions., PMID:22811539
Interleukin-32 enhances cytotoxic effect of natural killer cells to cancer cells via activation of death receptor 3., PMID:22043900
TL1A and DR3, a TNF family ligand-receptor pair that promotes lymphocyte costimulation, mucosal hyperplasia, and autoimmune inflammation., PMID:22017439
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation., PMID:20890040
TL1A induces the expression of TGF-β-inducible gene h3 (βig-h3) through PKC, PI3K, and ERK in THP-1 cells., PMID:20863486
Short hairpin RNA targeting beta-catenin suppresses cell proliferation and induces apoptosis in human gastric carcinoma cells., PMID:19958059
Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition., PMID:19805094
Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB., PMID:19670328
Inhibition of endothelial progenitor cell differentiation by VEGI., PMID:19329781
The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis., PMID:18824582
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation., PMID:18598698
Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation., PMID:18411341
TL1A both promotes and protects from renal inflammation and injury., PMID:18287561
Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes., PMID:15814728
Involvement of TL1A and DR3 in induction of pro-inflammatory cytokines and matrix metalloproteinase-9 in atherogenesis., PMID:15760679
TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells., PMID:12882979
Prevention of type 1 diabetes: where do we start?, PMID:12841534
Evidence for a role for apoptosis in central pontine myelinolysis., PMID:12012091
Specific features of apoptosis in human lens epithelial cells induced by mitomycin C in vitro., PMID:11585319
For research use only. Not for human or drug use.
