Catalog No.
FHD82512
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
PE
Target
HEK, Eph-like tyrosine kinase 1, EK4, EPHA3, Tyrosine-protein kinase receptor ETK1, Tyrosine-protein kinase TYRO4, Ephrin type-A receptor 3, hEK4, ETK, TYRO4, ETK1, Human embryo kinase, EPH-like kinase 4
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
P29320
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
SAA0126
Lutetium-177-PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial., PMID:40425844
EphA3-targeted chimeric antigen receptor T cells are effective in glioma and generate curative memory T cell responses., PMID:39111833
EphA3 CAR T cells are effective against glioblastoma in preclinical models., PMID:39111832
Inhibition of EphA3 Expression in Tumour Stromal Cells Suppresses Tumour Growth and Progression., PMID:37760615
Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome., PMID:37587118
Eph Receptors in Cancer., PMID:36830852
May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?, PMID:36613532
Longitudinal change of genetic variations in cetuximab-treated metastatic colorectal cancer., PMID:34315006
Antibody-mediated depletion of CCR10+EphA3+ cells ameliorates fibrosis in IPF., PMID:33945505
Intranasal Delivery of Temozolomide-Conjugated Gold Nanoparticles Functionalized with Anti-EphA3 for Glioblastoma Targeting., PMID:33417456
Aggressive variant of splenic marginal zone lymphoma characterized using a cancer panel test and treated with rituximab-containing chemotherapy: A case report., PMID:32871937
Critical role of EphA3 in cancer and current state of EphA3 drug therapeutics., PMID:32621117
Antibody Targeting of Eph Receptors in Cancer., PMID:32397088
The dystroglycan receptor maintains glioma stem cells in the vascular niche., PMID:31463571
EphA3 Pay-Loaded Antibody Therapeutics for the Treatment of Glioblastoma., PMID:30562956
Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting., PMID:30176744
Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma., PMID:29945963
EphA3 targeting reduces in vitro adhesion and invasion and in vivo growth and angiogenesis of multiple myeloma cells., PMID:28721629
Corrigendum to "KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study" [Leuk. Res. 50 (Nov) (2016) 123-131. PubMed PMID: 27736729]., PMID:28575698
Epha3 acts as proangiogenic factor in multiple myeloma., PMID:28415715
Comment on "KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study"., PMID:28129558
EphA3 as a target for antibody immunotherapy in acute lymphoblastic leukemia., PMID:27922598
Transcriptome and Proteome Analyses of TNFAIP8 Knockdown Cancer Cells Reveal New Insights into Molecular Determinants of Cell Survival and Tumor Progression., PMID:27807832
KB004, a first in class monoclonal antibody targeting the receptor tyrosine kinase EphA3, in patients with advanced hematologic malignancies: Results from a phase 1 study., PMID:27736729
Loss of EphA3 Protein Expression Is Associated With Advanced TNM Stage in Clear-Cell Renal Cell Carcinoma., PMID:27591824
Simultaneous targeting of Eph receptors in glioblastoma., PMID:27494882
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma., PMID:26895888
Altered S-nitrosothiol homeostasis provides a survival advantage to breast cancer cells in HER2 tumors and reduces their sensitivity to trastuzumab., PMID:26854735
A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity., PMID:25413948
Targeting EphA3 inhibits cancer growth by disrupting the tumor stromal microenvironment., PMID:25125683
EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme., PMID:23410976
Activation of ephrin A proteins influences hematopoietic stem cell adhesion and trafficking patterns., PMID:20655977
The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration., PMID:18814179
Monovalent, reduced-size quantum dots for imaging receptors on living cells., PMID:18425138
Comparison of EphA receptor tyrosine kinases and ephrinA ligand expression to EphB-ephrinB in vascularized corneas., PMID:17525654
Ephrin-A5 modulates the topographic mapping and connectivity of commissural axons in murine hippocampus., PMID:16690216
Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents., PMID:16061656
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling., PMID:15107857
EphA/ephrin-A interactions regulate epileptogenesis and activity-dependent axonal sprouting in adult rats., PMID:14697663
EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion., PMID:14697337
Topographic-specific axon branching controlled by ephrin-As is the critical event in retinotectal map development., PMID:11606643
Isolation and characterization of Dek, a Drosophila eph receptor protein tyrosine kinase., PMID:10356296
Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses., PMID:9499402
Expression and tyrosine phosphorylation of Eph receptors suggest multiple mechanisms in patterning of the visual system., PMID:9466885
Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor., PMID:9195962
Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines., PMID:1311845
Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor., PMID:1657122
For research use only. Not for human or drug use.
