Catalog No.
YHB85001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe332
Predicted molecular weight
39.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P00338
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Renal carcinoma antigen NY-REN-59, LDH-A, LDH muscle subunit, LDH-M, Cell proliferation-inducing gene 19 protein, L-lactate dehydrogenase A chain, LDHA
GCLM lactylation mediated by ACAT2 promotes ferroptosis resistance in KRASG12D-mutant cancer., PMID:40503938
PD-1 Regulates the Glycolytic Pathway to Reverse Abnormal CD4+ T Cell Differentiation and Alleviate Hashimoto's Thyroiditis., PMID:40503724
Gallic Acid Ameliorates Skeletal Muscle Metabolic Inflexibility by Regulating Lactate Metabolism and Promoting Mitochondrial Function., PMID:40491073
LDHA-Mediated H3K18 Lactylation Promotes the Glycolysis in Non-Small Cell Lung Cancer Through Targeting PTEN., PMID:40481934
Resveratrol mitigates cold exposure-induced apoptosis and energy metabolism disorder in broiler heart by mediating the p38-PI3K/AKT-NF-κB axis., PMID:40460596
Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8+ T cell anti-tumor immunity., PMID:40458308
ETV4 promotes the growth, metastasis, glycolysis, and oxaliplatin resistance of colorectal cancer by transcription activation-mediated SLC38A5 upregulation., PMID:40435908
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance., PMID:40425546
Baicalin Modulates Glycolysis via the PKC/Raf/MEK/ERK and PI3K/AKT Signaling Pathways to Attenuate IFN-I-Induced Neutrophil NETosis., PMID:40420943
LDHA-mediated YAP lactylation promotes the tumor progression of hepatocellular carcinoma by inducing YAP dephosphorylation and activation., PMID:40414964
The mechanism of ECT1/E6E7 cervical intraepithelial neoplasia cells regulated by Acinetobacter lwoffii through circ-LDHA/HMGB1., PMID:40414884
Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progression., PMID:40391156
Lactate dehydrogenase A-coupled NAD+ regeneration is critical for acute myeloid leukemia cell survival., PMID:40390151
Hepatocellular carcinoma cells downregulate PGAM2 via SIRT2-mediated deacetylation modification to enhance aerobic glycolysis., PMID:40379975
Esculetin inhibits liver cancer by targeting glucose-6-phosphate isomerase mediated glycolysis., PMID:40373632
Intracellular acetyl phosphate modulates Escherichia coli pyruvate metabolism., PMID:40370194
Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics., PMID:40354194
Targeted activation of junctional adhesion molecule-like protein+ CD8+ T cells enhances immunotherapy in hepatocellular carcinoma., PMID:40353078
HIF-1α regulated GLUT1-mediated glycolysis enhances Treponema pallidum-induced cytokine responses., PMID:40346557
Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory., PMID:40318634
Heterogenous cancer-associated fibroblasts related tumor microenvironment marked by CD10/KLF4/TIAM1 were identified in pancreatic adenocarcinoma by integrated transcriptomics., PMID:40303408
Proteomics unveils chemical modifications on protein side chains in raw breast meat of broilers (Gallus gallus) affected with growth-related myopathies., PMID:40302679
Cisplatin reduces immunosuppression caused by tumor-associated macrophages through downregulating CD47-SIRPα signaling in glioblastoma., PMID:40300658
Stallion spermatozoa express LDH isoforms A, B, and C, with LDHC playing a crucial role in sustaining sperm viability., PMID:40299647
Exploring the Therapeutic Mechanism of Jianpi Zhidong Decoction on Tourette Syndrome Based on Proteomics and Network Pharmacology., PMID:40291161
The METTL14-YTHDF1-SAP30 Axis Promotes Glycolysis and Oxaliplatin Resistance in Colorectal Adenocarcinoma via m6A Modification., PMID:40289460
SPAG4 Regulates Glycolytic Metabolism in HT29 Cells as a Target via the c-MYC/SULT2B1 Pathway., PMID:40287810
Role of lactate dehydrogenase A in the regulation of podocyte metabolism and glucose uptake under hyperglycemic conditions., PMID:40269097
LDHA-lactate axis modulates mitophagy inhibiting CSFV replication., PMID:40265937
Stibene glucoside prevents PM2.5 caused pulmonary fibrosis by Pseudo hypoxia, autophagy and NF-κB signal pathways., PMID:40262249
Interactions of tumor necrosis factor receptor-associated factor 4 and pyruvate kinase muscle isoform 2 promote malignant behavior and aerobic glycolysis in colorectal cancer cells., PMID:40260072
H3K9/18 lactylation regulates DNA damage due to nickel exposure in human bronchial epithelial cells., PMID:40250488
Mechanical Force Triggers Macrophage Pyroptosis and Sterile Inflammation by Disrupting Cellular Energy Metabolism., PMID:40244158
Triclosan-mediated metabolic oxidative stress-triggered cytoskeletal alterations in zebrafish gills and intestine: An integrated biomolecular and NMR-based metabolomics study., PMID:40239525
Comprehensive analysis of heat shock proteins in glioma revealed the association with glioma-associated myeloid cells., PMID:40234584
Chlorogenic Acid Improves High-Fat Diet-Induced Skeletal Muscle Metabolic Disorders by Regulating Mitochondrial Function and Lactate Metabolism., PMID:40232198
Exosomal circ_0001583 Drives Glioblastoma Cell Advancement Through the miR-647/CKAP2L Pathway., PMID:40229458
KAT3B Promotes the Glycolysis and Malignant Progression of Lung Cancer by Mediating the Succinylation Modification of PKM2., PMID:40226997
m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis., PMID:40220148
Integrated cartilage metabolomics and proteomics analysis reveals the therapeutic effect of Wenjing Tongluo Decoction on Knee osteoarthritis rats., PMID:40209497
Succinate-loaded tumor cell-derived microparticles reprogram tumor-associated macrophage metabolism., PMID:40203081
Metformin activates SIRT2 to improve insulin resistance and promote granulosa cell glycolysis in a rat model of polycystic ovary syndrome., PMID:40199656
Lactate activates trained immunity by fueling the tricarboxylic acid cycle and regulating histone lactylation., PMID:40185732
PKM2 crotonylation reprograms glycolysis in VSMCs, contributing to phenotypic switching., PMID:40181154
Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation., PMID:40164417
RNA Binding Protein IGF2BP3 Rehabilitates Glycolysis of Vascular Endothelial Cells to Protect the ox-LDL-induced Cellular Injury via Stabilizing LDHA mRNA., PMID:40159306
NSUN2/ALYREF-medicated m5C-modified circRNA505 regulates the proliferation, differentiation, and glycolysis of antler chondrocytes via the miRNA-127/p53 axis and LDHA., PMID:40147663
ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma., PMID:40139191
Knockdown of SLC7A5 inhibits malignant progression and attenuates oxaliplatin resistance in gastric cancer by suppressing glycolysis., PMID:40133832
METTL3 regulated by histone lactylation promotes ossification of the ligamentum flavum by enhancing the m6A methylation of BMP2., PMID:40133819
For research use only. Not for human or drug use.
