Catalog No.
YHB83801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val300-Ala540
Predicted molecular weight
29.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O96017
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RAD53, CHK2 checkpoint homolog, hCds1, Serine/threonine-protein kinase Chk2, CDS1, Checkpoint kinase 2, CHEK2, Hucds1, Cds1 homolog, CHK2
Moderate-Low Risk Breast Cancer Gene Expression in a Romanian Population., PMID:40508121
Hereditary breast cancer beyond BRCA: clinicopathological characteristics and long-term outcomes., PMID:40504267
Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors., PMID:40492861
Focal High-Grade Areas with a Tumor-in-Tumor Pattern: Another Feature of Pediatric DICER1-Associated Thyroid Carcinoma?, PMID:40448797
Activation of the MEK1-CHK2 axis in macrophages by Staphylococcus aureus promotes mitophagy, resulting in a reduction in bactericidal efficacy., PMID:40437411
Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage., PMID:40422251
Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysis., PMID:40403695
Clinical aspect of male breast cancer: a burgeoning and unaddressed issue., PMID:40358767
Breast Cancer Risk Modification in Women with Pathogenic Variants in BRCA1, BRCA2, ATM, CHEK2, and PALB2., PMID:40298171
Piperine derivative, (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-N-(2-hydroxyphenyl)penta-2,4-dienamide, exerted cytotoxic activity toward MCF-7 breast cancer cells via Apoptosis: Gene expression and biomolecular change study., PMID:40294461
Association of gene variant type and location with breast cancer risk in the general population., PMID:40288678
Short Report: The Variants in CHEK2 in Metastatic Uveal Melanoma., PMID:40283643
Genetic Features of Tumours Arising in the Context of Suspected Hereditary Cancer Syndromes with RAD50, RAD51C/D, and BRIP1 Germline Mutations, Results of NGS-Reanalysis of BRCA/MMR-Negative Families., PMID:40282418
Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type., PMID:40205496
Role of MRE11 in DNA damage repair pathway dynamics and its diagnostic and prognostic significance in hereditary breast and ovarian cancer., PMID:40205351
Targeting CHEK2-YBX1&YBX3 regulatory hub to potentiate immune checkpoint blockade response in gliomas., PMID:40161682
Association of a CHEK2 somatic variant with tumor microenvironment calprotectin expression predicts platinum resistance in a small cohort of ovarian carcinoma., PMID:40146757
Analysis of germline-somatic mutational connections in colorectal cancer reveals differential tumorigenic patterns and a novel predictive marker for germline mutation carriers., PMID:40118241
[Pathogenic role of CHEK2 variants in Hungarian cancer patients: implications for breast cancer risk and genetic counselling]., PMID:40117483
Effects of breast size on breast reconstruction in BRCA mutation carriers and genetic high-risk patients after bilateral mastectomy., PMID:40113717
ADAM9 mediates Cisplatin resistance in gastric cancer cells through DNA damage response pathway., PMID:40108033
Pan-cancer genetic profiles of mitotic DNA integrity checkpoint protein kinases., PMID:40095483
Germline variants in CDKN2A wild-type melanoma prone families., PMID:40072281
ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment., PMID:40057605
Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma., PMID:40056603
Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan., PMID:40050371
Pathogenic germline variants in Chinese pancreatic adenocarcinoma patients., PMID:40044664
Breast, Colorectal, and Pancreatic Cancer Mortality With Pathogenic Variants in ATM, CHEK2, or PALB2., PMID:40020204
Germline-Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking ATM to TP53 Synthetic Essentiality., PMID:40019487
Population-based study of recurrent DNA damage response gene variants in breast cancer cases., PMID:40009290
STM2457 impairs the proliferation of esophageal squamous cell carcinoma by activating DNA damage response through ATM-Chk2 axis., PMID:39985567
Late Recurrent Spitz Melanoma With a TMEM106B :: BRAF Fusion., PMID:39983065
Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases., PMID:39971927
CHEK2-related breast cancer: real-world challenges., PMID:39966186
Comprehensive bioinformatics analysis of selected germline variants of uncertain significance identified in a cohort of Sri Lankan hereditary breast cancer patients., PMID:39940038
FGFR2/3 Gene Alterations and Clinical Outcomes in Advanced/Metastatic Urothelial Cancer in Japan: MONSTAR-SCREEN Database Study., PMID:39933925
Germline Pathogenic Variants and Clinical Outcomes in Asian Patients With Breast Cancer., PMID:39930910
CD8+ T cells in patients with hypopharyngeal squamous cell carcinoma are susceptible to radiation-induced damage., PMID:39918311
Retrospective Study of Genetic Testing Results Reveals Pathogenic Variants Beyond BRCA1/2 in Hereditary Breast and Ovarian Cancer Cases in New Brunswick: Implications for Future Care., PMID:39907309
Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth., PMID:39887032
FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion., PMID:39868925
Heterogeneity of the Treatment Effect with PARP Inhibitors in Metastatic Castration-resistant Prostate Cancer: A Living Interactive Systematic Review and Meta-analysis., PMID:39848867
ZNF703 promotes Triple-Negative breast cancer cell progression and in combination with STK11 predicts disease recurrence (ZS -TNBC Model)., PMID:39828065
Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population., PMID:39815370
Breast Cancer Susceptibility Gene Sequence Variations and Development of Contralateral Breast Cancer., PMID:39786405
Landscape of Multilocus Inherited Neoplasia Allele Syndrome in Mexican Population., PMID:39778127
Double CHEK2 Pathogenic and Low-Risk Variants and Associated Cancer Phenotypes., PMID:39745704
ATM/ATR-Mediated DNA Damage Response Facilitates SARS-CoV-2 Spike Protein-Induced Syncytium Formation., PMID:39740081
Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation., PMID:39737931
For research use only. Not for human or drug use.
