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Recombinant Human CHEK2 Protein, N-His

Catalog #:   YHB83801 Specific References (49) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: O96017
Protein length: Val300-Ala540
Overview

Catalog No.

YHB83801

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Val300-Ala540

Predicted molecular weight

29.45 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

O96017

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

RAD53, CHK2 checkpoint homolog, hCds1, Serine/threonine-protein kinase Chk2, CDS1, Checkpoint kinase 2, CHEK2, Hucds1, Cds1 homolog, CHK2

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human CHEK2 protein
References

Moderate-Low Risk Breast Cancer Gene Expression in a Romanian Population., PMID:40508121

Hereditary breast cancer beyond BRCA: clinicopathological characteristics and long-term outcomes., PMID:40504267

Beyond DNA damage response: Immunomodulatory attributes of CHEK2 in solid tumors., PMID:40492861

Focal High-Grade Areas with a Tumor-in-Tumor Pattern: Another Feature of Pediatric DICER1-Associated Thyroid Carcinoma?, PMID:40448797

Activation of the MEK1-CHK2 axis in macrophages by Staphylococcus aureus promotes mitophagy, resulting in a reduction in bactericidal efficacy., PMID:40437411

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage., PMID:40422251

Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysis., PMID:40403695

Clinical aspect of male breast cancer: a burgeoning and unaddressed issue., PMID:40358767

Breast Cancer Risk Modification in Women with Pathogenic Variants in BRCA1, BRCA2, ATM, CHEK2, and PALB2., PMID:40298171

Piperine derivative, (2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-N-(2-hydroxyphenyl)penta-2,4-dienamide, exerted cytotoxic activity toward MCF-7 breast cancer cells via Apoptosis: Gene expression and biomolecular change study., PMID:40294461

Association of gene variant type and location with breast cancer risk in the general population., PMID:40288678

Short Report: The Variants in CHEK2 in Metastatic Uveal Melanoma., PMID:40283643

Genetic Features of Tumours Arising in the Context of Suspected Hereditary Cancer Syndromes with RAD50, RAD51C/D, and BRIP1 Germline Mutations, Results of NGS-Reanalysis of BRCA/MMR-Negative Families., PMID:40282418

Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type., PMID:40205496

Role of MRE11 in DNA damage repair pathway dynamics and its diagnostic and prognostic significance in hereditary breast and ovarian cancer., PMID:40205351

Targeting CHEK2-YBX1&YBX3 regulatory hub to potentiate immune checkpoint blockade response in gliomas., PMID:40161682

Association of a CHEK2 somatic variant with tumor microenvironment calprotectin expression predicts platinum resistance in a small cohort of ovarian carcinoma., PMID:40146757

Analysis of germline-somatic mutational connections in colorectal cancer reveals differential tumorigenic patterns and a novel predictive marker for germline mutation carriers., PMID:40118241

[Pathogenic role of CHEK2 variants in Hungarian cancer patients: implications for breast cancer risk and genetic counselling]., PMID:40117483

Effects of breast size on breast reconstruction in BRCA mutation carriers and genetic high-risk patients after bilateral mastectomy., PMID:40113717

ADAM9 mediates Cisplatin resistance in gastric cancer cells through DNA damage response pathway., PMID:40108033

Pan-cancer genetic profiles of mitotic DNA integrity checkpoint protein kinases., PMID:40095483

Germline variants in CDKN2A wild-type melanoma prone families., PMID:40072281

ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment., PMID:40057605

Discovery of 4-(2-(methylamino)thiazol-5-yl)pyrimidin-2-amine derivatives as novel cyclin-dependent kinase 12 (CDK12) inhibitors for the treatment of esophageal squamous cell carcinoma., PMID:40056603

Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan., PMID:40050371

Pathogenic germline variants in Chinese pancreatic adenocarcinoma patients., PMID:40044664

Breast, Colorectal, and Pancreatic Cancer Mortality With Pathogenic Variants in ATM, CHEK2, or PALB2., PMID:40020204

Germline-Somatic Interactions in BRCA-Associated Cancers: Unique Molecular Profiles and Clinical Outcomes Linking ATM to TP53 Synthetic Essentiality., PMID:40019487

Population-based study of recurrent DNA damage response gene variants in breast cancer cases., PMID:40009290

STM2457 impairs the proliferation of esophageal squamous cell carcinoma by activating DNA damage response through ATM-Chk2 axis., PMID:39985567

Late Recurrent Spitz Melanoma With a TMEM106B :: BRAF Fusion., PMID:39983065

Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases., PMID:39971927

CHEK2-related breast cancer: real-world challenges., PMID:39966186

Comprehensive bioinformatics analysis of selected germline variants of uncertain significance identified in a cohort of Sri Lankan hereditary breast cancer patients., PMID:39940038

FGFR2/3 Gene Alterations and Clinical Outcomes in Advanced/Metastatic Urothelial Cancer in Japan: MONSTAR-SCREEN Database Study., PMID:39933925

Germline Pathogenic Variants and Clinical Outcomes in Asian Patients With Breast Cancer., PMID:39930910

CD8+ T cells in patients with hypopharyngeal squamous cell carcinoma are susceptible to radiation-induced damage., PMID:39918311

Retrospective Study of Genetic Testing Results Reveals Pathogenic Variants Beyond BRCA1/2 in Hereditary Breast and Ovarian Cancer Cases in New Brunswick: Implications for Future Care., PMID:39907309

Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth., PMID:39887032

FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion., PMID:39868925

Heterogeneity of the Treatment Effect with PARP Inhibitors in Metastatic Castration-resistant Prostate Cancer: A Living Interactive Systematic Review and Meta-analysis., PMID:39848867

ZNF703 promotes Triple-Negative breast cancer cell progression and in combination with STK11 predicts disease recurrence (ZS -TNBC Model)., PMID:39828065

Los olvidados: Non-BRCA variants associated with Hereditary breast cancer in Mexican population., PMID:39815370

Breast Cancer Susceptibility Gene Sequence Variations and Development of Contralateral Breast Cancer., PMID:39786405

Landscape of Multilocus Inherited Neoplasia Allele Syndrome in Mexican Population., PMID:39778127

Double CHEK2 Pathogenic and Low-Risk Variants and Associated Cancer Phenotypes., PMID:39745704

ATM/ATR-Mediated DNA Damage Response Facilitates SARS-CoV-2 Spike Protein-Induced Syncytium Formation., PMID:39740081

Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation., PMID:39737931

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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For research use only. Not for human or drug use.

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Recombinant Human CHEK2 Protein, N-His [YHB83801]
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