Catalog No.
YHB82301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr31-Gly194
Predicted molecular weight
19.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95998
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-18-binding protein, IL-18BP, IL18BP, Tadekinig-alfa
The Potential Contribution of the IL-37/IL-18/IL-18BP/IL-18R Axis in the Pathogenesis of Sjögren's Syndrome., PMID:40430016
Elevated serum levels of interleukin-18 discriminate Still's disease from other autoinflammatory conditions: results from the European ImmunAID cohort., PMID:40341183
Low serum free IL-18 is a novel potential marker for predicting infectious events in patients at dialysis initiation., PMID:40322680
Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis., PMID:40239621
NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine tolerance., PMID:40217343
A robust diagnostic model for high-risk MASH: integrating clinical parameters and circulating biomarkers through a multi-omics approach., PMID:40205303
Interleukin-18 Binding Protein (IL-18BP) Deficiency Affects Lymphocyte Activation and IL-18 Expression in a Mouse Model of Liver Inflammation., PMID:40170380
Elevated Plasma Interleukin-18 Levels in Head and Neck Squamous Cell Carcinoma: Correlation With IL-18 Binding Protein But Not Ferritin., PMID:40037860
Development of anti-murine IL-18 binding protein antibodies to stimulate IL-18 bioactivity., PMID:40018678
Subtype-associated complexity and prognostic significance of the NLRP3 inflammasome landscape in pancreatic neoplasms., PMID:39969214
Free Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer., PMID:39890196
Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis., PMID:39888602
Exploring the role of circulating proteins in multiple myeloma risk: a Mendelian randomization study., PMID:39885253
Combined delivery of IL12 and an IL18 mutant without IL18BP-binding activity by an adenoviral vector enhances tumor specific immunity., PMID:39875404
Computational modeling of the anti-inflammatory complexes of IL37., PMID:39854883
IL-18 and IL-18BP: A Unique Dyad in Health and Disease., PMID:39769266
Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18., PMID:39631848
Decoy-resistant IL-18 reshapes the tumor microenvironment and enhances rejection by anti-CTLA-4 in renal cell carcinoma., PMID:39561007
Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease., PMID:39462545
Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030
Interleukin-1 family cytokines and soluble receptors in hidradenitis suppurativa., PMID:39278731
Hyperferritinemia Screening to Aid Identification and Differentiation of Patients with Hyperinflammatory Disorders., PMID:39264477
Identification of biomarkers for COVID-19 associated secondary hemophagocytic lymphohistiocytosis., PMID:39185173
IL-18 signaling is regulated by caspase 6/8 and IL-18BP in turbot (Scophthalmus maximus)., PMID:39181350
[Autoinflammatory diseases associated with IL-18]., PMID:39155178
Brief Pain Inventory (BPI) Pain Survey Versus Cysteine Protease Caspase-1 (Casp1) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer., PMID:39060040
Interleukin-18 binding protein regulates mast cell activation and mast cell induced osteoclastogenesis of rheumatoid arthritis., PMID:39058477
Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults., PMID:39009607
Hyperferritinemia screening to aid identification and differentiation of patients with hyperinflammatory disorders., PMID:38978562
IL-18BP Therapy Ameliorates Reproductive and Metabolic Phenotypes in a PCOS Mouse Model by Relieving Inflammation, Fibrosis and Endoplasmic Reticulum Stress., PMID:38977641
Plasmatic Inactive IL-18 Predicts a Worse Overall Survival for Advanced Non-Small-Cell Lung Cancer with Early Metabolic Progression after Immunotherapy Initiation., PMID:38927931
Correlation Between Blood Levels of Cysteine Protease Caspase-1 (Casp1) and Pain Scores (NRS) Post-surgery: A Prospective Randomized Study of Patients With Cholelithiasis., PMID:38925829
Insights into IL-1 family cytokines in kidney allograft transplantation: IL-18BP and free IL-18 as emerging biomarkers., PMID:38801805
Acquisition of different transcriptional shear mRNA and biological function of porcine interleukin 18 binding protein in PRRSV infection., PMID:38727246
Effect of NLRP3 Inflammasome on Lung Cancer Immune Microenvironment Activation and Its Mechanism., PMID:38687849
Blood Interleukin-18 (IL-18) and IL-18 Binding Protein (IL-18BP) Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer., PMID:38677734
Interleukin‑18 binding protein: Biological properties and roles in human and animal immune regulation (Review)., PMID:38665423
Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects., PMID:38592331
Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder., PMID:38509197
Ratios between the Levels of IL-18, Free IL-18, and IL-1β-Binding Protein Depending on the Severity and Outcome of COVID-19., PMID:38488959
Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application., PMID:38455460
KL6 and IL-18 levels are negatively correlated with respiratory function tests and ILD extent assessed on HRCT in patients with systemic sclerosis-related interstitial lung disease (SSc-ILD)., PMID:38290372
Autoantibody-Mediated Depletion of IL-1RA in Still's Disease and Potential Impact of IL-1 Targeting Therapies., PMID:38231276
Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity., PMID:38135702
The autoinflammation-associated NLRC4V341A mutation increases microbiota-independent IL-18 production but does not recapitulate human autoinflammatory symptoms in mice., PMID:38090573
Efficacy of Fowlpox Virus Vector Vaccine Expressing VP2 and Chicken Interleukin-18 in the Protection against Infectious Bursal Disease Virus., PMID:38006048
Interleukin-18 in cancer immunology and immunotherapy., PMID:37993172
Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment., PMID:37935565
Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18., PMID:37934469
Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation., PMID:37918054
For research use only. Not for human or drug use.
