Catalog No.
YHB77701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala31-Leu265
Predicted molecular weight
27.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95865
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DDAH, Dimethylargininase-2, NG30, DDAHII, DDAH2, Protein G6a, N(G),N(G)-dimethylarginine dimethylaminohydrolase 2, S-phase protein, G6A, Dimethylarginine dimethylaminohydrolase 2, DDAH-2
L-arginine dependence of breast cancer - molecular subtypes matter., PMID:40140975
Atypical antipsychotics impair the lipid-lowering and pleiotropic effects of simvastatin via activation of the ADMA-NOX-ROS pathway., PMID:40058152
Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients., PMID:39962199
Urine proteome profile of firefighters with exposure to emergency fire-induced smoke: A pilot study to identify potential carcinogenic effects., PMID:38583625
Redefining the biological and pathophysiological role of dimethylarginine dimethylaminohydrolase 2., PMID:38553332
Proteomics analyses of acute kidney injury biomarkers in a rat exertional heat stroke model., PMID:37378075
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer., PMID:36765702
Asymmetric dimethylarginine accumulation under hyperglycemia facilitates β-cell apoptosis via inhibiting nitric oxide production., PMID:36395692
Beyond eNOS: Genetic influence in NO pathway affecting drug response., PMID:36264109
Single cell sequencing analysis identifies genetics-modulated ORMDL3+ cholangiocytes having higher metabolic effects on primary biliary cholangitis., PMID:34872583
Interference of KLF9 relieved the development of gestational diabetes mellitus by upregulating DDAH2., PMID:34787071
Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway., PMID:34438260
Evaluation of Biological Mechanisms of Eucommiae Folium in Hypertensive Kidney Injury by Integration of Untargeted Metabolomics and Network Pharmacology., PMID:34018394
Divergent Dimethylarginine Dimethylaminohydrolase Isoenzyme Expression in the Central Nervous System., PMID:34014421
DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission., PMID:33850055
Regulation of dimethylarginine dimethylaminohydrolase 2 expression by NF-κB acetylation., PMID:33335577
Upregulation of DDAH2 Limits Pulmonary Hypertension and Right Ventricular Hypertrophy During Chronic Hypoxia in Ddah1 Knockout Mice., PMID:33281630
L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs., PMID:32932854
Renal asymmetric dimethylarginine inhibits fibrosis., PMID:32794631
Metabolism of asymmetric dimethylarginine in hypoxia: from bench to bedside., PMID:32313644
Enhancing kidney DDAH-1 expression by adenovirus delivery reduces ADMA and ameliorates diabetic nephropathy., PMID:31904280
The detrimental effect of asymmetric dimethylarginine on cholesterol efflux of macrophage foam cells: Role of the NOX/ROS signaling., PMID:31437479
Blockade of Cardiac Proton Pump Impairs Ventricular Remodeling Through a Superoxide-DDAH-Dependent Pathway in Infarcted Rats., PMID:30930564
DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats., PMID:30569164
Oxymatrine prevents the development of monocrotaline-induced pulmonary hypertension via regulation of the NG, NG-dimethyl-L-arginine metabolism pathways in rats., PMID:30419238
Neuropilin-1 maintains dimethylarginine dimethylaminohydrolase 1 expression in endothelial cells, and contributes to protection from angiotensin II-induced hypertension., PMID:30118322
Nephroprotective effects of nebivolol in 2K1C rats through regulation of the kidney ROS-ADMA-NO pathway., PMID:30099298
Nebivolol ameliorated kidney damage in Zucker diabetic fatty rats by regulation of oxidative stress/NO pathway: Comparison with captopril., PMID:29935093
The effects of proton pump inhibitor on hepatic vascular responsiveness and hemodynamics in cirrhotic rats., PMID:29780000
Asymmetric dimethylarginine contributes to retinal neovascularization of diabetic retinopathy through EphrinB2 pathway., PMID:29777874
Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats., PMID:29119338
Impaired Arginine Metabolism Coupled to a Defective Redox Conduit Contributes to Low Plasma Nitric Oxide in Polycystic Ovary Syndrome., PMID:29055959
Association of the -449GC and -1151AC polymorphisms in the DDAH2 gene with asymmetric dimethylarginine and erythropoietin resistance in Chinese patients on maintenance hemodialysis., PMID:28590543
Critical role of vascular peroxidase 1 in regulating endothelial nitric oxide synthase., PMID:28264790
Determine exogenous human DDAH2 gene function in rabbit bone marrow-derived endothelial progenitor cells in vitro., PMID:28150318
Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis., PMID:28082806
Protective effects of low-dose rosuvastatin on isoproterenol-induced chronic heart failure in rats by regulation of DDAH-ADMA-NO pathway., PMID:27957828
[Effects and related mechanism of 5-aza-2'-deoxycytidine on endothelial function in rats with hyperhomocysteinemia]., PMID:27545130
Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia., PMID:27319282
Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis., PMID:27181226
Epigallocatechin-3-gallate ameliorates erectile function in aged rats via regulation of PRMT1/DDAH/ADMA/NOS metabolism pathway., PMID:27080477
GNB2 is a mediator of lidocaine-induced apoptosis in rat pheochromocytoma PC12 cells., PMID:27018092
Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2., PMID:26911182
N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice., PMID:26887666
Placental NRP1 and VEGF expression in pre-eclamptic women and in a homocysteine-treated mouse model of pre-eclampsia., PMID:26708340
Genotype polymorphisms of genes regulating nitric oxide synthesis determine long-term arteriovenous fistula patency in male hemodialysis patients., PMID:26643995
Demethylation treatment restores erectile function in a rat model of hyperhomocysteinemia., PMID:26585696
Dimethylarginine dimethylaminohydrolase 2 promotes tumor angiogenesis in lung adenocarcinoma., PMID:26515557
[Ad-hVEGF165 reverses homocysteine-induced endothelial dysfunction by regulating nitric oxide system]., PMID:26419990
Dimethylarginine dimethylaminohydrolase-1 mediates inhibitory effect of interleukin-10 on angiotensin II-induced hypertensive effects in vascular smooth muscle cells of spontaneously hypertensive rats., PMID:26375520
For research use only. Not for human or drug use.
