Catalog No.
FHC33342
Description
The PAC-1 antibody is derived from the fusion of SP-2 mouse myeloma cells with splenic lymphocytes from BALB/c mice that were immunized with human platelets.
The PAC-1 recognizes an epitope on the glycoprotein IIb/IIIa (gpIIb/IIIa, αIIbβ3) complex of activated platelets at or near the platelet fibrinogen receptor.
Species reactivity
Human
Host species
Mouse
Isotype
IgM, kappa
Clonality
Monoclonal
Conjugation
PE
Target
CD41, ITGAB, GPIIb, ITGA2B, Platelet membrane glycoprotein IIb, GP2B, Integrin alpha-IIb, GPalpha IIb, GPIIIa, Integrin beta-3, CD61, ITGB3, Platelet membrane glycoprotein IIIa, GP3A, PAC-1
Concentration
0.5 mg/ml
Endotoxin level
Please contact with the lab for this information.
Accession
P08514 & P05106
Applications
FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Stability and Storage
Store at 4°C for 12 months. Protect from light. Do not freeze.
Clone ID
PAC-1
An αIIbβ3 Ligand-Mimetic Murine Monoclonal Antibody That Produces Platelet Activation by Engaging the FcγIIa Receptor., PMID:40101235
Influence of sodium ferulate on neutrophil extracellular traps-platelet activation-mediated endothelial dysfunction in immune small vasculitis., PMID:39917008
Absence of platelet overactivation and thrombosis formation among patients with coronary atherosclerosis disease after vaccination against SARS-CoV-2., PMID:39640769
Association between O-GlcNAc levels and platelet function in obese insulin-resistant subjects., PMID:39300054
Platelet transfusion enhances pro-aggregatory status shortly after coronary artery bypass grafting (CABG while modulating platelet pro-inflammatory state 1-week post-surgery., PMID:39121235
An αIIbβ3 monoclonal antibody traps a semiextended conformation and allosterically inhibits large ligand binding., PMID:38968144
Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase-activating polypeptide (PACAP) in invertebrate physiology., PMID:38940930
Off-target effect of high-dose sildenafil on adenosine 5'- diphosphate and collagen-induced platelet activation through mitogen-activated protein kinase pathway in treated BALB/C mice and in vitro experiments: A preliminary study., PMID:38808925
Optimization of Platelet-Rich Plasma Preparation for Regenerative Medicine: Comparison of Different Anticoagulants and Resuspension Media., PMID:38534483
Feasibility and comparability of different platelet function tests in acute stroke with or without prior antiplatelet therapy., PMID:38410198
Targeting the PACAP-38 pathway is an emerging therapeutic strategy for migraine prevention., PMID:38337150
Investigation of the role of von Willebrand factor in shear-induced platelet activation and functional alteration under high non-physiological shear stress., PMID:38112069
The effects of glucocorticoid plus intravenous immunoglobulin (IVIG) vs IVIG alone on platelet activation in children with Kawasaki disease., PMID:37661679
Future targets for migraine treatment beyond CGRP., PMID:37370051
A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia., PMID:36884296
Platelet Activation and Cytokine Release of Interleukin-8 and Interferon-Gamma-Induced Protein 10 after ChAdOx1 nCoV-19 Coronavirus Vaccine Injection., PMID:36851332
PAC1, VPAC1, and VPAC2 Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies., PMID:36430275
Clot-targeted magnetic hyperthermia permeabilizes blood clots to make them more susceptible to thrombolysis., PMID:35950914
Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel., PMID:35037555
Platelet Phenotype and Function Changes With Increasing Duration of Extracorporeal Membrane Oxygenation., PMID:35020670
Levels of procoagulant microparticles expressing phosphatidylserine contribute to bleeding phenotype in patients with inherited thrombocytopenia., PMID:34475331
Evaluation of Platelet Activation by HIV Protease Inhibitors - The HIV-PLA II Study., PMID:34393518
Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination., PMID:34388849
Platelet reticulated forms, size indexes and functional activity. Interactions in healthy volunteers., PMID:34029503
Emerging Targets for Migraine Treatment., PMID:34003154
Difference in inflammation, atherosclerosis, and platelet activation between coronary artery aneurysm and coronary artery ectasia., PMID:33209413
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19., PMID:32887634
Small procoagulant platelets in diabetes type 2., PMID:32629151
Tracing the Origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP)., PMID:32508559
Platelet hyperactivation in multiple myeloma is also evident in patients with premalignant monoclonal gammopathy of undetermined significance., PMID:32478420
Intestinal microbiota dysbiosis play a role in pathogenesis of patients with primary immune thrombocytopenia., PMID:32272276
Activated platelets kill Staphylococcus aureus, but not Streptococcus pneumoniae-The role of FcγRIIa and platelet factor 4/heparinantibodies., PMID:32237268
Acquired Glanzmann thrombasthenia associated with platelet desialylation., PMID:31869497
Expression of platelet parameters and platelet membrane glycoproteins in childhood Burkitt lymphoma., PMID:31326577
Altered activation of integrin ɑIIbβ3 on platelets irradiated with ultraviolet C from pathogen-reducing xenon flash., PMID:31105058
Drug-induced activation of integrin alpha IIb beta 3 leads to minor localized structural changes., PMID:30978226
Reduced β2-GPI is associated with increased platelet aggregation and activation in patients with prolonged isolated thrombocytopenia after allo-HSCT., PMID:30929196
First description of an IgM monoclonal antibody causing αIIb β3 integrin activation and acquired Glanzmann thrombasthenia associated with macrothrombocytopenia., PMID:30868743
Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa., PMID:30692520
Digoxin and Platelet Activation in Patients With Atrial Fibrillation: In Vivo and In Vitro Study., PMID:30571484
Platelet activity and hypercoagulation in type 2 diabetes., PMID:30388964
A unique phenotype of acquired Glanzmann thrombasthenia due to non-function-blocking anti-αIIbβ3 autoantibodies., PMID:30388316
Impact of Escherichia coli K12 and O18:K1 on human platelets: Differential effects on platelet activation, RNAs and proteins., PMID:30385858
A Proposed Role of Surfactant in Platelet Function and Treatment of Pulmonary Hemorrhage in Preterm and Term Infants., PMID:30343298
A preliminary study of platelet hyperactivity in the chronic indeterminate phase of Chagas' disease., PMID:33601755
PACAP38 and PAC1 receptor blockade: a new target for headache?, PMID:30088106
PACAP38 in human models of primary headaches., PMID:29453754
Adding to the complexity of fetal and neonatal alloimmune thrombocytopenia: Reduced fibrinogen binding in the presence of anti-HPA-1a antibody and hypo-responsive neonatal platelets., PMID:29306729
Increased platelet activation occurs in cystic fibrosis patients and correlates to clinical status., PMID:29274562
Acute Impact of Different Exercise Modalities on Arterial and Platelet Function., PMID:29240651
For research use only. Not for human or drug use.
