Anti-Human CD220/INSR Antibody (SAA0334), PE

Catalog No.

FHC19122

Species reactivity

Human

Host species

Mouse

Isotype

IgG2a, kappa

Clonality

Monoclonal

Conjugation

PE

Target

INSR, IR, CD220, Insulin receptor

Concentration

0.5 mg/ml

Endotoxin level

Please contact with the lab for this information.

Accession

P06213

Applications

FCM, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.

Stability and Storage

Store at 4°C for 12 months. Protect from light. Do not freeze.

Clone ID

SAA0334

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway., PMID:34184083

Rare causes of hypoglycemia in adults., PMID:32409005

The expression of the insulin receptor in gastric cancer correlates with the HER2 status and may have putative therapeutic implications., PMID:30989432

Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis., PMID:30586741

Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment., PMID:30559346

Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study., PMID:30201849

Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models., PMID:29700562

Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology., PMID:29067674

Detection of Islet Cell Immune Reactivity with Low Glycemic Index Foods: Is This a Concern for Type 1 Diabetes?, PMID:28819632

Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein., PMID:28279069

Diabetic Ketoacidosis Without Diabetes., PMID:27636019

Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer., PMID:27765027

Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies., PMID:27572805

Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189

Type B insulin resistance syndrome., PMID:27254267

A Novel Allosteric Insulin Receptor-Activating Antibody Reduces Hyperglycemia without Hypoglycemia in Diabetic Cynomolgus Monkeys., PMID:26578267

Insulin treatment promotes tyrosine phosphorylation of PKR and inhibits polyIC induced PKR threonine phosphorylation., PMID:26321373

Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor., PMID:26263910

Insulin family polymorphisms in pregnancies complicated by small for gestational age infants., PMID:26089371

Successful pregnancy outcomes in a patient with type A insulin resistance syndrome., PMID:25472847

Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys., PMID:24889100

Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation., PMID:24652289

Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity., PMID:24533136

Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer., PMID:24338270

Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor., PMID:23192358

Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling., PMID:22982059

Correlation between gene expression of IGF-1R pathway markers and cetuximab benefit in metastatic colorectal cancer., PMID:22294722

Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier., PMID:22230573

Altered expression of insulin receptor isoforms in breast cancer., PMID:22046260

Biologic TNFα-inhibitors that cross the human blood-brain barrier., PMID:21327054

Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein., PMID:20100527

A modified protocol for efficient DNA encapsulation into pegylated immunoliposomes (PILs)., PMID:19545595

Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology., PMID:19093871

N-linked glycans of the human insulin receptor and their distribution over the crystal structure., PMID:17957771

Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation., PMID:16779704

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