Catalog No.
YHB65901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys178-Asp245
Predicted molecular weight
34.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95453
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Deadenylating nuclease, Polyadenylate-specific ribonuclease, Poly(A)-specific ribonuclease PARN, Deadenylation nuclease, PARN, DAN
Comprehensive Bioinformatics Analysis for the Identification of Hub Genes and Critical Signaling Pathways Differentiating Latent and Active Tuberculosis., PMID:40444623
Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells., PMID:39392174
PARN Maintains RNA Stability to Regulate Insulin Maturation and GSIS in Pancreatic β Cells., PMID:39297407
Brain-wide mapping of c-Fos expression in nitroglycerin-induced models of migraine., PMID:39169303
A new variant in the ZCCHC8 gene: diverse clinical phenotypes and expression in the lung., PMID:38375433
Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase., PMID:38244197
NTHL1 is a recessive cancer susceptibility gene., PMID:38036545
Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA Polymerase., PMID:37808652
Cross-talk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells., PMID:37747775
Thyroid transcriptomic profiling reveals the differential regulation of lncRNA and mRNA related to prolificacy in Small Tail Han sheep with FecB++ genotype., PMID:37694839
Poly(A)-specific ribonuclease protein promotes the proliferation, invasion and migration of esophageal cancer cells., PMID:37664151
The PARN, TOE1, and USB1 RNA deadenylases and their roles in non-coding RNA regulation., PMID:37544646
A FinnGen pilot clinical recall study for Alzheimer's disease., PMID:37537264
CSDE1 promotes miR-451 biogenesis., PMID:37493604
Poly (A)-specific ribonuclease deficiency impacts oogenesis in zebrafish., PMID:37340076
Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy., PMID:37285119
Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening., PMID:37002320
A novel loss-of-function variant in PNLDC1 inducing oligo-astheno-teratozoospermia and male infertility., PMID:36960498
The Genetic and Epigenetic Footprint in Idiopathic Pulmonary Fibrosis and Familial Pulmonary Fibrosis: A State-of-the-Art Review., PMID:36553114
Maternal mRNA deadenylation and allocation via Rbm14 condensates facilitate vertebrate blastula development., PMID:36477743
SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein., PMID:36337685
RNASeq profiling of COVID19-infected patients identified an EIF2AK2 inhibitor as a potent SARS-CoV-2 antiviral., PMID:36321336
How genetic defects in piRNA trimming contribute to male infertility., PMID:36263612
Telomere biology disorders: time for moving towards the clinic?, PMID:36057525
Domain specific mutations in dyskerin disrupt 3' end processing of scaRNA13., PMID:36018809
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis., PMID:35978133
[Telomeres and lung]., PMID:35715316
Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis., PMID:35417304
New insights into the genetic etiology of Alzheimer's disease and related dementias., PMID:35379992
A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis., PMID:35217638
Genotype-Phenotype Relationships in Inheritable Idiopathic Pulmonary Fibrosis: A Greek National Cohort Study., PMID:35078193
Primary age-related tauopathy in a Finnish population-based study of the oldest old (Vantaa 85+)., PMID:34927275
PARN-like Proteins Regulate Gene Expression in Land Plant Mitochondria by Modulating mRNA Polyadenylation., PMID:34639116
Poly (A)-specific ribonuclease (PARN): More than just "mRNA stock clearing"., PMID:34520768
Pulmonary fibrosis in dyskeratosis congenita: a case report with a PRISMA-compliant systematic review., PMID:34479523
pre-piRNA trimming and 2'-O-methylation protect piRNAs from 3' tailing and degradation in C. elegans., PMID:34469728
Lifetime risk of rheumatoid arthritis-associated interstitial lung disease in MUC5B mutation carriers., PMID:34344703
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease., PMID:34187600
Association of the MYOC p.(Gln368Ter) Variant With Glaucoma in a Finnish Population., PMID:34081096
The role of polygenic risk and susceptibility genes in breast cancer over the course of life., PMID:33318493
Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants., PMID:33230308
Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes., PMID:33184027
An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease., PMID:33110245
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells., PMID:33057200
Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations., PMID:33035329
Effects of epidermal growth factor and progesterone on oocyte meiotic resumption and the expression of maturation-related transcripts during prematuration of oocytes from small and medium-sized bovine antral follicles., PMID:32943135
[Clinical value of biomarkers in diagnosis and treatment of idiopathic pulmonary fibrosis]., PMID:32895164
Regulation of human telomerase RNA biogenesis and localization., PMID:32813614
For research use only. Not for human or drug use.
