Catalog No.
YHB65401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu104
Predicted molecular weight
13.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95436
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NaPi2b,Sodium/phosphate cotransporter 2B, Na(+)-dependent phosphate cotransporter 2B, Na(+)/Pi cotransporter 2B, Sodium-dependent phosphate transport protein 2B, NaPi3b, NaPi-2b, SLC34A2, Solute carrier family 34 member 2, Sodium-phosphate transport protein 2B
Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications., PMID:40279260
T330M Substitution in the Sodium-Dependent Phosphate Transporter NaPi2b Abolishes the Efficacy of Monoclonal Antibodies Against MX35 Epitope., PMID:40265411
A Novel Variant in Pulmonary Alveolar Microlithiasis With Disseminated Pseudomonas Infection., PMID:40233944
Development of a reliable risk prognostic model for lung adenocarcinoma based on the genes related to endotheliocyte senescence., PMID:40221448
Partial renal deletion of Klotho is not sufficient to impact renal electrolyte handling in distal convoluted tubule specific knock-out mice., PMID:40165603
High expression of SLC34A2 contributes to chemoresistance of non-small cell lung cancer against gefitinib: The critical role of miR-124-3p., PMID:39579521
Effects of SLC34A3 or SLC34A1 variants on calcium and phosphorus homeostasis., PMID:39256228
The Effect of Seminal Plasma on the Equine Endometrial Transcriptome., PMID:39246124
Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes., PMID:39179330
Vitamin D3 suppresses Npt2c abundance and differentially modulates phosphate and calcium homeostasis in Npt2a knockout mice., PMID:39043847
Fusion Genes Landscape of Lung Cancer Patients From Inner Mongolia, China., PMID:39011998
Discovery of a first-in-class protein degrader for the c-ros oncogene 1 (ROS1)., PMID:38955003
Physiological and transcriptomic analysis provides new insights into osmoregulation mechanism of Ruditapes philippinarum under low and high salinity stress., PMID:38750748
Empagliflozin drives ferroptosis in anoikis-resistant cells by activating miR-128-3p dependent pathway and inhibiting CD98hc in breast cancer., PMID:38734268
SLC34A2 Targets in Calcium/Phosphorus Homeostasis of Mammary Gland and Involvement in Development of Clinical Mastitis in Dairy Cows., PMID:38731279
SLC34A2 promotes cell proliferation by activating STX17-mediated autophagy in esophageal squamous cell carcinoma., PMID:38720472
CRISPR/Cas9-edited ROS1 + non-small cell lung cancer cell lines highlight differential drug sensitivity in 2D vs 3D cultures while reflecting established resistance profiles., PMID:38433235
Mechanisms of Resistance to Tyrosine Kinase Inhibitors in ROS1 Fusion-Positive Nonsmall Cell Lung Cancer., PMID:38416709
Severe pulmonary hypertension in pulmonary alveolar microlithiasis: A comprehensive literature review., PMID:38342349
CD74/SLC34A2-ROS1 Fusion Variants Involving the Transmembrane Region Predict Poor Response to Crizotinib in NSCLC Independent of TP53 Mutations., PMID:38070598
A novel compound heterozygous mutation in the SLC34A2 gene causes pulmonary alveolar microlithiasis., PMID:38070491
Detection of clinically actionable gene fusions by next-generation sequencing-based RNA sequencing of non-small cell lung cancer cytology specimens: A single-center experience with comparison to fluorescence in situ hybridization., PMID:37747438
Alectinib relieves ischemic strokes caused by left atrial metastasis in a NSCLC patient with a novel SLC34A2-ALK (exon 1: exon 15) fusion., PMID:37542770
New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review., PMID:37259144
Retraction statement: Shao, L., Zhang, X. and Yao, Q. (2020), The F-box protein FBXO11 restrains hepatocellular carcinoma stemness via promotion of ubiquitin-mediated degradation of Snail. FEBS Open Bio, 10: 1810-1820., PMID:37219054
Is SLC34A2 Associated With Concomitant Calcium Metabolism Disorder in Pulmonary Alveolar Microlithiasis (PAM)?, PMID:37217383
TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2., PMID:37139431
Pharmacology of Mammalian Na+-Dependent Transporters of Inorganic Phosphate., PMID:36592227
Screening of possible biomarkers and therapeutic targets in kidney renal clear cell carcinoma: Evidence from bioinformatic analysis., PMID:36313709
Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability., PMID:36253446
Toward a Topology-Based Therapeutic Design of Membrane Proteins: Validation of NaPi2b Topology in Live Ovarian Cancer Cells., PMID:35911971
Transient DUX4 expression in human embryonic stem cells induces blastomere-like expression program that is marked by SLC34A2., PMID:35777358
[Pulmonary alveolar microlithiasis caused by SLC34A2 gene compound heterozygous variations in a child]., PMID:35768363
FAM111A is dispensable for electrolyte homeostasis in mice., PMID:35715480
Design, synthesis and biological evaluation of novel indole derivatives as gut-selective NaPi2b inhibitors., PMID:35576656
Impaired phosphate transport in SLC34A2 variants in patients with pulmonary alveolar microlithiasis., PMID:35443721
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer., PMID:35437317
Novel SLC12A1 mutations cause Bartter syndrome in two patients with different prognoses., PMID:35358470
Design, synthesis and biological evaluation of novel pyridine derivatives as gut-selective NaPi2b inhibitors., PMID:35346844
Pulmonary Alveolar Microlithiasis: A novel patient and brief review of the literature., PMID:35139546
Design, synthesis and biological evaluation of novel 1H-pyrazole-4-carbonyl-4,5,6,7-tetrahydrobenzo [b]thiophene derivatives as gut-selective NaPi2b inhibitors., PMID:35066140
Pulmonary Alveolar Microlithiasis - A Review., PMID:34970102
NaPi2b expression in a large surgical Non-Small Cell Lung Cancer (NSCLC) cohort., PMID:34953676
Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases., PMID:34944522
Construction and Validation of Prognostic Regulation Network Based on RNA-Binding Protein Genes in Lung Squamous Cell Carcinoma., PMID:34931870
SLC34A2 promotes cancer proliferation and cell cycle progression by targeting TMPRSS3 in colorectal cancer., PMID:34929599
Enhanced supply of methionine regulates protein synthesis in bovine mammary epithelial cells under hyperthermia condition., PMID:34796352
Restoration of mRNA Expression of Solute Carrier Proteins in Liver of Diet-Induced Obese Mice by Metformin., PMID:34659115
Reference standards for gene fusion molecular assays on cytological samples: an international validation study., PMID:34429353
SLC34A2 Up-regulation And SLC4A4 Down-regulation Correlates With Invasion, Metastasis, And The MAPK Signaling Pathway In Papillary Thyroid Carcinomas., PMID:34405007
For research use only. Not for human or drug use.
