Catalog No.
YHB64901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val1385-Thr1525
Predicted molecular weight
18.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95425
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
p205/p250, SVIL, Supervillin, Archvillin
AKT1E17K-Interacting lncRNA SVIL-AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation., PMID:40135844
Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy., PMID:39966646
Significance of Gelsolin Superfamily Genes in Diagnosis, Prognosis and Immune Microenvironment Regulation for Endometrial Cancer., PMID:39964147
Supervillin-Mediated ZO-1 Downregulation Facilitates Migration of Cisplatin-Resistant HCT116 Colorectal Cancer Cells., PMID:39745006
SVIL promotes ovarian cancer progression and epithelial-mesenchymal transition under hypoxic conditions through the TGF-β/Smad pathway., PMID:39197416
CRH upregulates supervillin through ERK and AKT pathways to promote bladder cancer cell migration., PMID:39090812
Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection., PMID:38745208
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation., PMID:38565986
Duality of the SVIL expression in bladder cancer and its correlation with immune infiltration., PMID:37670039
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation., PMID:36973285
Large scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy., PMID:36778260
Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy., PMID:36576983
Somatic Variants in SVIL in Cerebral Aneurysms., PMID:36475054
N6-methyladenosine-induced SVIL antisense RNA 1 restrains lung adenocarcinoma cell proliferation by destabilizing E2F1., PMID:35068325
Novel γ-sarcoglycan interactors in murine muscle membranes., PMID:35065666
Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis., PMID:34773240
In vitro transcriptome response to propolis in differentiated SH-SY5Y neurons., PMID:34730243
Transcriptomics Analysis Identifies the Presence of Upregulated Ribosomal Housekeeping Genes in the Alveolar Macrophages of Patients with Smoking-Induced Chronic Obstructive Pulmonary Disease., PMID:34588774
Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages., PMID:34480249
Dual role of Fam208a during zygotic cleavage and early embryonic development., PMID:34216590
Genome-wide DNA methylation profiling and gut flora analysis in intestinal polyps patients., PMID:34213504
Molecular basis of functional exchangeability between ezrin and other actin-membrane associated proteins during cytokinesis., PMID:33862101
Loss of supervillin causes myopathy with myofibrillar disorganization and autophagic vacuoles., PMID:32779703
A twin‑pair analysis indicates congenital scoliosis is associated with allele‑specific methylation in the SVIL gene., PMID:32582973
Supervillin promotes tumor angiogenesis in liver cancer., PMID:32468064
Characteristics of Human OAS1 Isoform Proteins., PMID:32013110
Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations., PMID:31719662
Fam208a orchestrates interaction protein network essential for early embryonic development and cell division., PMID:31112734
Activating Structural Alterations in MAPK Genes Are Distinct Genetic Drivers in a Unique Subgroup Of Spitzoid Neoplasms., PMID:30640733
Generation and characterization of monoclonal antibodies that recognize human and murine supervillin protein isoforms., PMID:30332471
Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway., PMID:29954442
Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking., PMID:29410425
Dynamics and function of ERM proteins during cytokinesis in human cells., PMID:28889652
A genome-wide association study meta-analysis of clinical fracture in 10,012 African American women., PMID:28580392
A novel splice variant of supervillin, SV5, promotes carcinoma cell proliferation and cell migration., PMID:27825967
Supervillin Is a Component of the Hair Cell's Cuticular Plate and the Head Plates of Organ of Corti Supporting Cells., PMID:27415442
Lecithin Prevents Cortical Cytoskeleton Reorganization in Rat Soleus Muscle Fibers under Short-Term Gravitational Disuse., PMID:27073851
Preparation and Affinity-Purification of Supervillin Isoform 4 (SV4) Specific Polyclonal Antibodies., PMID:27015936
CONTENT OF CYTOSKELETON PROTEINS IN OOCYTES OF THIRD GENERATION DROSOPHILA MELANOGASTER FRUIT FLIES OBTAINED AFTER A 44.5-DAY SPACE FLIGHT., PMID:29873978
Analysis of genes involved in response to doxorubicin and a GD2 ganglioside-specific 14G2a monoclonal antibody in IMR-32 human neuroblastoma cells., PMID:26284262
Characterization of cells cultured from chylous effusion from a patient with sporadic lymphangioleiomyomatosis., PMID:26026094
Molecular toggle switch of histone demethylase LSD1., PMID:25794611
A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation., PMID:25684206
Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation., PMID:25655724
Gamma-sarcoglycan is required for the response of archvillin to mechanical stimulation in skeletal muscle., PMID:25605665
Supervillin binding to myosin II and synergism with anillin are required for cytokinesis., PMID:24088567
The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing., PMID:23750008
Supervillin-mediated suppression of p53 protein enhances cell survival., PMID:23382381
Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress., PMID:22550155
Supervillin couples myosin-dependent contractility to podosomes and enables their turnover., PMID:22344260
For research use only. Not for human or drug use.
