Catalog No.
YHB62201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr196
Predicted molecular weight
23.14 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95372
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LYPLA2, APT-2, LysoPLA II, LPL-II, Acyl-protein thioesterase 2, Lysophospholipase II, APT2
Alteration of the metabolite interconversion enzyme in sperm and Sertoli cell of non-obstructive azoospermia: a microarray data and in-silico analysis., PMID:39472682
Identification of a novel target of sulforaphane: Sulforaphane binds to acyl-protein thioesterase 2 (APT2) and attenuates its palmitoylation., PMID:38905785
Bioprobe-RNA-seq-microRaman system for deep tracking of the live single-cell metabolic pathway chemometrics., PMID:38896978
Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus., PMID:37039765
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1., PMID:36803235
N-1,2,3-Triazole-isatin derivatives: anti-proliferation effects and target identification in solid tumour cell lines., PMID:36092141
A defective lysophosphatidic acid-autophagy axis increases miscarriage risk by restricting decidual macrophage residence., PMID:35220880
Protein Palmitoylation in Bovine Ovarian Follicle., PMID:34769186
Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation., PMID:34666187
Analysis of the Neuroproteome Associated With Cell Therapy After Intranigral Grafting in a Mouse Model of Parkinson Disease., PMID:33776636
Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains., PMID:33707782
A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis., PMID:33029007
Rapid Solid-Phase Construction of Serine Hydrolase Probes Results in Selective Activity-Based Probes for Acyl Protein Thioesterases-1/2., PMID:32990443
Identification of a metabolism-related gene expression prognostic model in endometrial carcinoma patients., PMID:32894095
Fluorophosphonate-Based Degrader Identifies Degradable Serine Hydrolases by Quantitative Proteomics., PMID:32501609
FOLFOX treatment response prediction in metastatic or recurrent colorectal cancer patients via machine learning algorithms., PMID:31893575
Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways., PMID:31556464
Palmitoylation is required for TNF-R1 signaling., PMID:31382980
Targeting MC1R depalmitoylation to prevent melanomagenesis in redheads., PMID:30787281
Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling., PMID:30482805
Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases., PMID:30393067
Differential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases., PMID:30228356
Protein depalmitoylases., PMID:29239216
Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade., PMID:28826475
APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells., PMID:28065656
Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2)., PMID:27748579
Chemoproteomic, biochemical and pharmacological approaches in the discovery of inhibitors targeting human α/β-hydrolase domain containing 11 (ABHD11)., PMID:27544863
Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells., PMID:26771141
Enzymatic protein depalmitoylation by acyl protein thioesterases., PMID:25849916
miRs-138 and -424 control palmitoylation-dependent CD95-mediated cell death by targeting acyl protein thioesterases 1 and 2 in CLL., PMID:25670628
The importance of age and statin therapy in the interpretation of Lp-PLA(2) in ACS patients, and relation to CRP., PMID:25317678
Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells., PMID:25301951
Identification of palmitoyltransferase and thioesterase enzymes that control the subcellular localization of axon survival factor nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2)., PMID:25271157
Alterations of choline phospholipid metabolism in endometrial cancer are caused by choline kinase alpha overexpression and a hyperactivated deacylation pathway., PMID:25267063
Omuralide and vibralactone: differences in the proteasome- β-lactone-γ-lactam binding scaffold alter target preferences., PMID:24285701
2-Bromopalmitate reduces protein deacylation by inhibition of acyl-protein thioesterase enzymatic activities., PMID:24098372
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii., PMID:23913689
Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43., PMID:23396970
Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes., PMID:22690931
Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels., PMID:22399288
Differential gene expression of blood-derived cell lines in familial combined hyperlipidemia., PMID:15388524
Sequence, expression in Escherichia coli, and characterization of lysophospholipase II., PMID:10064901
For research use only. Not for human or drug use.
