Catalog No.
YHB48101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr32-His266
Predicted molecular weight
28.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94907
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1
Activation of the Wnt signaling pathway and its role in epithelial-mesenchymal transition and hepatic fibrosis in alveolar echinococcosis., PMID:40496021
Proteomics profiling reveals the potential targets of Apatinib inhibiting the proliferation of glioma U251 cell., PMID:40493991
Gastrodin promotes osteogenic differentiation by stimulating the Wnt/β-catenin signaling pathway., PMID:40436074
Identification of different lung adenocarcinoma subtypes in combination with antidiuretic hormone-related genes and creation of an associated index to predict prognosis and guide immunotherapy., PMID:40412340
Cancer-associated loss-of-function mutations in KCNQ1 enhance Wnt/β-catenin signalling disrupting epithelial homeostasis., PMID:40410368
Voglibose Attenuates Amyloid Beta-Induced Memory Deficits in a Rodent Model: A Potential Alzheimer's Therapy via Wnt Signaling Modulation., PMID:40381169
Bone Remodeling in Children with Acute Lymphoblastic Leukemia: A Two-Year Prospective Longitudinal Study., PMID:40362542
Catalpol Protects Against Retinal Ischemia Through Antioxidation, Anti-Ischemia, Downregulation of β-Catenin, VEGF, and Angiopoietin-2: In Vitro and In Vivo Studies., PMID:40362263
Plastrum Testudinis Stimulates Bone Formation through Wnt/β-catenin Signaling Pathway Regulated by miR-214., PMID:40358879
Inhibition of Canonical Wnt Signaling in Renal Cell Carcinoma Bone Metastasis: An Immunohistochemical Analysis of DKK1 and LRP5 Expression., PMID:40337977
Calcaratarin D, a labdane diterpenoid, attenuates bleomycin-induced pulmonary fibrosis by blocking Wnt/β-catenin signaling pathway., PMID:40311955
A novel Wnt/β-catenin signaling gene signature for progression and metastasis of gastric cancer., PMID:40296906
Computational analysis of zoanthamine alkaloids from Zoanthus sp. as potential DKK1 and GSK-3β inhibitors for osteoporosis therapy via Wnt signaling., PMID:40274944
MIR155HG suppresses the osteogenic differentiation of bone marrow mesenchymal stem cells through regulating miR-155-5p and DKK1 expression., PMID:40251598
LncRNA H19 inhibited dermal papilla cell senescence process through miR-29a by targeting Wnt/β-catenin signaling pathway., PMID:40204984
Exploration of the pharmacological substance basis and efficacy evaluation of fufang she-she-cao (Hedyotis diffusa formula) in repressing gastric cancer., PMID:40185259
Astragaloside IV inhibits nasopharyngeal carcinoma progression by suppressing the SATB2/Wnt signaling axis., PMID:40177383
Research Progress on the Influence of Novel Targeted Drugs for Osteoporosis on Glucose Metabolism., PMID:40149867
The effect of 1,25(OH)2D3 on Dickkopf-1 methylation in colorectal cancer., PMID:40140935
Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway., PMID:40129942
Accelerating Bone Healing With METTL3 Overexpressed Adipose-Derived Stem Cells in Osteoporotic Rats., PMID:40125696
[Mechanism of electroacupuncture in improving cartilage tissue injury in rats with knee osteoarthritis by regulating miR-335-5p expression]., PMID:40103383
YTHDC1 Modulates the Osteogenic Capacity of hPDLSCs via Wnt/β-Catenin Signalling Pathway for the Treatment of Bone Defects in Osteoporosis Rats., PMID:40097906
Deficiency of neuronal LGR4 increases energy expenditure and inhibits food intake via hypothalamic leptin signaling., PMID:40069508
Blocking the Dkk1-LRP6 interaction prevents acute amyloid-β-driven cognitive impairment., PMID:40057150
Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb., PMID:40055364
Chiari malformation type 1 with combined nuclear PAX1 and DKK1 genes and mitochondrial D-loop variants: a case report., PMID:40047162
Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions., PMID:40025612
Wnt1 oversees microglial activation by the Wnt/LRP5/6 receptor signaling pathway during lipopolysaccharide-mediated toxicity., PMID:40025242
Novel biomarkers in bone pathophysiology: Establishing reference intervals and biological variations estimates for serum leptin, sclerostin, lipocalin-2, osteoprotegerin, resistin and Dickkopf-related protein-1 from the European biological variation study (EuBIVAS) populations., PMID:40010661
Exploring the molecular interactions between ferroptosis and the Wnt/β-catenin signaling pathway: Implications for cancer and disease therapy., PMID:40010619
LRP5 enhances glioma cell proliferation by modulating the MAPK/p53/cdc2 pathway., PMID:39991761
Long non-coding RNA PRKG1-AS1 promotes cell proliferation and migration in lung adenocarcinoma., PMID:39984932
Study on the mechanism of Wnt/β-catenin pathway mediated by pterostilbene to reduce cerebral ischemia-reperfusion injury., PMID:39976471
Metformin reverses 5-FU chemoresistance by downregulating DKK1, WNT5A, and ABCB1 expressions in gastric cancer: An experimental and bioinformatic study., PMID:39954066
The glycoprotein GPNMB protects against oxidative stress through enhanced PI3K/AKT signaling in epidermal keratinocytes., PMID:39947468
A novel function of the Wnt antagonist secreted frizzled-related protein 4 as a transcriptional regulator of Dickkopf-1, another Wnt antagonist, in glioblastoma cell line U87MG., PMID:39938692
Anti-androgenetic effect of diphlorethohydroxycarmalol on testosterone-induced hair loss by inhibiting 5α-reductase and promoting Wnt/β-catenin signaling pathway in human dermal papilla cells., PMID:39922549
Dickkopf 1 and Neuregulin 1 as cutaneous biomarkers for dermal pigmentation activity in acquired dermal macular hyperpigmentation (ADMH): a case control study., PMID:39921734
Amyloid-β can activate JNK signalling via WNT5A-ROR2 to reduce synapse formation in Alzheimer's disease., PMID:39907042
Wnt signaling as a translational target in rheumatoid and psoriatic arthritis., PMID:39905450
Vdr mediates Wnt signaling pathway to regulate odontoblasts differentiation during dentin apposition., PMID:39894431
Dickkopf-1 is present in equine platelet-rich plasma and correlates to platelet concentration., PMID:39892398
Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer., PMID:39885132
Ablation of LRP6 in alpha-smooth muscle actin-expressing cells abrogates lung inflammation and fibrosis upon bleomycin-induced lung injury., PMID:39873304
Single-Cell RNA Sequencing Reveals LEF1-Driven Wnt Pathway Activation as a Shared Oncogenic Program in Hepatoblastoma and Medulloblastoma., PMID:39851951
Yangyin Yiqi Huoxue Decoction improves the mechanism of microglia activation against CIS-induced neuroinflammatory injury by regulating the Wnt signaling pathway., PMID:39826286
Targeting unique ligand binding domain structural features downregulates DKK1 in Y537S ESR1 mutant breast cancer cells., PMID:39825366
Decreasing miR-433-3p Activity in the Osteoblast Lineage Blunts Glucocorticoid-mediated Bone Loss., PMID:39820728
Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma., PMID:39805917
For research use only. Not for human or drug use.
