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Research Grade Lirilumab (DHE43401)

Host species:Human
Isotype:IgG4-kappa
Applications:Research Grade Biosimilar
Expression system:XtenCHO
Overview

Catalog No.

DHE43401

Expression system

XtenCHO

Species reactivity

Human

Host species

Human

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

CD158 antigen-like family member A, KIR2DL1, Killer cell immunoglobulin-like receptor 2DL1, Natural killer-associated transcript 1, NKAT-1, MHC class I NK cell receptor, CD158A, p58 natural killer cell receptor clones CL-42/47.11, CD158a, p58.1 MHC class-I-specific NK receptor, NKAT1, p58 NK receptor CL-42/47.11, p58 NK receptor CL-43, NKAT-6, NKAT6, MHC class I NK cell receptor, CD158 antigen-like family member B1, CD158b1, p58 natural killer cell receptor clone CL-43, Natural killer-associated transcript 6, CD158B1, KIR2DL2, Killer cell immunoglobulin-like receptor 2DL2, NKAT2b, KIR2DL3, p58 natural killer cell receptor clone CL-6, p58.2 MHC class-I-specific NK receptor, CD158 antigen-like family member B2, MHC class I NK cell receptor, KIR-023GB, Killer inhibitory receptor cl 2-3, p58 NK receptor CL-6, CD158b2, Killer cell immunoglobulin-like receptor 2DL3, Natural killer-associated transcript 2, CD158B2, KIRCL23, NKAT-2, NKAT2a, NKAT2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P43626 & P43627 & P43628

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

BMS-986015, IPH2102, CAS: 1000676-41-4

Data Image
  • Bioactivity
    Detects Human CD158b1/KIR2DL2 in indirect ELISAs.
  • SDS-PAGE
    SDS PAGE for Lirilumab
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

A Pilot Trial of Lirilumab With or Without Azacitidine for Patients With Myelodysplastic Syndrome, PMID: 30001986

A phase 1 study of lirilumab (antibody against killer immunoglobulin-like receptor antibody KIR2D; IPH2102) in patients with solid tumors and hematologic malignancies, PMID: 29707140

A phase 1b study of dual PD-1 and CTLA-4 or KIR blockade in patients with relapsed/refractory lymphoid malignancies, PMID: 32601377

High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals, PMID: 28723950

Immunogenomic correlates of response to cetuximab monotherapy in head and neck squamous cell carcinoma, PMID: 30828910

Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies, PMID: 24326534

How to outsmart NK cell tolerance, PMID: 26405590

Trial Watch: Immunostimulatory monoclonal antibodies in cancer therapy, PMID: 24701370

Datasheet

Document Download

Research Grade Lirilumab.pdf

 

$ 328
Product specifications
100 μg 328 1 mg 1314

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

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Research Grade Lirilumab [DHE43401]
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